Abstract: Various embodiments of the disclosed subject matter provide systems, methods, architectures, mechanisms, apparatus and/or computer implemented method configured for automatically managing En Route Care (ERC) transport patient and medical equipment loading.

Abstract: Compositions and methods for suppressing cancer cell growth by a synthetic chromatin effector. For example, a synthetic histone-binding regulator protein, polycomb-based transcription factor (PcTF), is utilized to activate suppression of cancer cell growth. Accordingly, an exemplary method disclosed herein may directly target a generally conserved feature, such as elevated trimethyl-lysine 27 on histone H3 (H3K27me3), with PcTF. In addition, a set of 19 PcTF-upregulated genes, or PUGs, that were consistent across three distinct breast cancer cell lines, were identified. These genes are associated with the interferon response pathway. The results demonstrate for the first time a chromatin-mediated interferon-related transcriptional response driven by an engineered fusion protein that physically links repressive histone marks with active transcription.