Patents by Inventor Melody A. Swartz

Melody A. Swartz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240044896
    Abstract: Aspects of the disclosure are directed to methods, systems, and compositions for detecting antibodies capable of binding to angiotensin II. Certain aspects comprise detection of antibodies capable of binding to angiotensin II in a sample from a subject, where the subject has or has had a coronavirus infection, such as a SARS-CoV-2 infection. Also disclosed are vaccine compositions comprising a portion of SARS-CoV-2 Spike protein, where such compositions do not induce generation of angiotensin II-binding antibodies.
    Type: Application
    Filed: December 9, 2021
    Publication date: February 8, 2024
    Applicant: The University of Chicago
    Inventors: Melody SWARTZ, Priscilla BRIQUEZ, Jeffrey HUBBELL
  • Publication number: 20230377764
    Abstract: The methods and compositions described herein address the need in the art by providing compositions and methods for a therapy with an antibody that is specifically targeted to and/or retained intra- or peri-tumorally, limiting systemic exposure and reducing side-effects. Accordingly, aspects of the disclosure relate to a composition comprising an immunotherapeutic antibody operatively linked to an extracellular matrix (ECM)-affinity peptide. An ECM-affinity peptide is one that has affinity for an extracellular matrix protein.
    Type: Application
    Filed: February 3, 2023
    Publication date: November 23, 2023
    Applicant: The University of Chicago
    Inventors: Jeffrey A. HUBBELL, Jun ISHIHARA, Ako ISHIHARA, Kazuto FUKUNAGA, Melody SWARTZ
  • Patent number: 11574747
    Abstract: The methods and compositions described herein address the need in the art by providing compositions and methods for a therapy with an antibody that is specifically targeted to and/or retained intra- or peri-tumorally, limiting systemic exposure and reducing side-effects. Accordingly, aspects of the disclosure relate to a composition comprising an immunotherapeutic antibody operatively linked to an extracellular matrix (ECM)-affinity peptide. An ECM-affinity peptide is one that has affinity for an extracellular matrix protein.
    Type: Grant
    Filed: April 20, 2018
    Date of Patent: February 7, 2023
    Assignee: The University of Chicago
    Inventors: Jeffrey A. Hubbell, Jun Ishihara, Ako Ishihara, Kazuto Fukunaga, Melody Swartz
  • Publication number: 20220168448
    Abstract: An encoding/decoding apparatus and method using a low-density parity-check code (LDPC code) is disclosed. Basic column group information, serving as a set of information regarding positions of rows with weight 1, is extracted from a reference column in each column group of a predetermined parity-check matrix. Column group information transforms the positions of rows with weight 1 into positions whose lengths are within a required parity length. A parity-check matrix is generated according to the generated column group information. Data is enclosed or decoded based on the generated parity-check matrix.
    Type: Application
    Filed: July 2, 2021
    Publication date: June 2, 2022
    Inventors: Jeffrey A. HUBBELL, Conlin P. O'NEIL, Melody SWARTZ, Diana VELLUTO, André Van Der Vlies
  • Publication number: 20220047700
    Abstract: The present invention concerns methods and compositions for evoking protective immune responses against pathogen infection or cancer. In certain embodiments, the methods and compositions comprise a lymphangiogenesis inducer and an antigen.
    Type: Application
    Filed: November 5, 2021
    Publication date: February 17, 2022
    Applicant: The University of Chicago
    Inventors: Jeffrey A. Hubbell, Melody A. Swartz, Shann S. Yu, Efthymia Vokali, Manuel Fankhauser, Sachiko Hirosue, Priscilla S. Briquez, Maria Broggi, Lambert Potin, Maria Stella Sasso
  • Patent number: 10980877
    Abstract: The present invention concerns methods and compositions for evoking protective immune responses against pathogen infection or cancer. In certain embodiments, the methods and compositions comprise a lymphangiogenesis inducer and an antigen.
    Type: Grant
    Filed: April 28, 2017
    Date of Patent: April 20, 2021
    Assignee: The University of Chicago
    Inventors: Melody A. Swartz, Jeffrey A. Hubbell, Shann Yu, Efthymia Vokali, Manuel Fankhauser, Sachiko Hirosue, Priscilla S. Briquez, Maria Broggi, Lambert Potin, Maria Stella Sasso
  • Publication number: 20210094995
    Abstract: The methods and compositions described herein address the need in the art by providing compositions and methods for a therapy with a cytokine that is specifically targeted to and/or retained intra- or peri-tumorally, limiting systemic exposure and reducing side-effects. Accordingly, aspects of the disclosure relate to a composition comprising an immunotherapeutic antibody operatively linked to an extracellular matrix (ECM)-affinity peptide. An ECM-affinity peptide is one that has affinity for an extracellular matrix protein.
    Type: Application
    Filed: March 5, 2019
    Publication date: April 1, 2021
    Inventors: Jeffrey A. HUBBELL, Jun ISHIHARA, Ako ISHIHARA, Koichi SASAKI, Melody SWARTZ, Aslan MANSUROV
  • Publication number: 20200123228
    Abstract: The methods and compositions described herein address the need in the art by providing compositions and methods for a therapy with an antibody that is specifically targeted to and/or retained intra- or peri-tumorally, limiting systemic exposure and reducing side-effects. Accordingly, aspects of the disclosure relate to a composition comprising an immunotherapeutic antibody operatively linked to an extracellular matrix (ECM)-affinity peptide. An ECM-affinity peptide is one that has affinity for an extracellular matrix protein.
    Type: Application
    Filed: April 20, 2018
    Publication date: April 23, 2020
    Inventors: Jeffrey A. HUBBELL, Jun ISHIHARA, Ako ISHIHARA, Kazuto FUKUNAGA, Melody SWARTZ
  • Publication number: 20200000936
    Abstract: An encoding/decoding apparatus and method using a low-density parity-check code (LDPC code) is disclosed. Basic column group information, serving as a set of information regarding positions of rows with weight 1, is extracted from a reference column in each column group of a predetermined parity-check matrix. Column group information transforms the positions of rows with weight 1 into positions whose lengths are within a required parity length. A parity-check matrix is generated according to the generated column group information. Data is enclosed or decoded based on the generated parity-check matrix.
    Type: Application
    Filed: July 1, 2019
    Publication date: January 2, 2020
    Inventors: James Brandon DIXON, Jeffrey A. Hubbell, Conlin P. O'Neil, Melody Swartz, Diana Velluto
  • Patent number: 10335499
    Abstract: Block copolymers containing charged blocks or chemical moieties sensitive to oxidation or hydrolysis have been developed. We describe the use of such block copolymers in supramolecular structures, e.g., micelles or vesicles, and pharmaceutical compositions and in methods of preparing the supramolecular structures and pharmaceutical compositions. The invention is particularly useful for the delivery of pharmaceutical agents, e.g., nucleic acids, to cells.
    Type: Grant
    Filed: February 5, 2016
    Date of Patent: July 2, 2019
    Assignee: École Polytechnique Fédérale de Lausanne (EPFL)
    Inventors: James Brandon Dixon, Jeffrey A. Hubbell, Conlin P. O'Neil, Melody Swartz, Diana Velluto
  • Publication number: 20190099485
    Abstract: The present invention concerns methods and compositions for evoking protective immune responses against pathogen infection or cancer. In certain embodiments, the methods and compositions comprise a lymphangiogenesis inducer and an antigen.
    Type: Application
    Filed: April 28, 2017
    Publication date: April 4, 2019
    Inventors: Melody A. Swartz, Jeffrey A. Hubbell, Shann Yu, Efthymia Vokali, Manuel Fankhauser, Sachiko Hirosue, Priscilla S. Briquez, Maria Broggi, Lambert Potin, Maria Stella Sasso
  • Publication number: 20160256569
    Abstract: Block copolymers containing charged blocks or chemical moieties sensitive to oxidation or hydrolysis have been developed. We describe the use of such block copolymers in supramolecular structures, e.g., micelles or vesicles, and pharmaceutical compositions and in methods of preparing the supramolecular structures and pharmaceutical compositions. The invention is particularly useful for the delivery of pharmaceutical agents, e.g., nucleic acids, to cells.
    Type: Application
    Filed: February 5, 2016
    Publication date: September 8, 2016
    Inventors: James Brandon DIXON, Jeffrey A. HUBBELL, Conlin P. O'NEIL, Melody SWARTZ, Diana VELLUTO
  • Patent number: 9271929
    Abstract: An encoding/decoding apparatus and method using a low-density parity-check code (LDPC code) is disclosed. Basic column group information, serving as a set of information regarding positions of rows with weight 1, is extracted from a reference column in each column group of a predetermined parity-check matrix. Column group information transforms the positions of rows with weight 1 into positions whose lengths are within a required parity length. A parity-check matrix is generated according to the generated column group information. Data is encoded or decoded based on the generated parity-check matrix.
    Type: Grant
    Filed: November 24, 2009
    Date of Patent: March 1, 2016
    Assignee: École Polytechnique Fédérale de Lausanne (EPFL)
    Inventors: James Brandon Dixon, Jeffrey A. Hubbell, Conlin P. O'Neil, Melody Swartz, Diana Velluto
  • Patent number: 8592364
    Abstract: Chemokines may be administered to a patient for immunotolerization. Chemokines include CCL19 and CCL21. Materials and methods for accomplishing tolerization and described.
    Type: Grant
    Filed: February 10, 2011
    Date of Patent: November 26, 2013
    Assignee: Ecole Polytechnique Federale de Lausanne (“EPFL”)
    Inventors: Melody A. Swartz, Jeffrey A. Hubbell, Alice A. Tomei, Jacqueline D. Shields, Iraklis Kourtis
  • Patent number: 8323696
    Abstract: Nanoparticles that activate complement in the absence of biological molecules are described. The nanoparticles are shown to specifically target antigen presenting cells in specifically in lymph nodes, without the use of a biological molecule for targeting. These particles are useful vehicles for delivering immunotherapeutics. Surface chemistries and chemical formulations for the nanoparticles are described.
    Type: Grant
    Filed: August 29, 2008
    Date of Patent: December 4, 2012
    Assignee: Ecole Polytechnique Federale de Lausanne
    Inventors: Jeffrey A. Hubbell, Conlin P. O'Neil, Sai T. Reddy, Melody A. Swartz, Diana Velluto, André van der Vlies, Eleonora Simeoni
  • Patent number: 8021689
    Abstract: Nanoparticles that activate complement in the absence of biological molecules are described. The nanoparticles are shown to specifically target antigen presenting cells in specifically in lymph nodes, without the use of a biological molecule for targeting. These particles are useful vehicles for delivering immunotherapeutics.
    Type: Grant
    Filed: February 19, 2007
    Date of Patent: September 20, 2011
    Assignee: Ecole Polytechnique Federale de Lausanne (“EPFL”)
    Inventors: Sai T. Reddy, Jeffrey A. Hubbell, Melody A. Swartz, André van der Vlies
  • Publication number: 20110223217
    Abstract: An encoding/decoding apparatus and method using a low-density parity-check code (LDPC code) is disclosed. Basic column group information, serving as a set of information regarding positions of rows with weight 1, is extracted from a reference column in each column group of a predetermined parity-check matrix. Column group information transforms the positions of rows with weight 1 into positions whose lengths are within a required parity length. A parity-check matrix is generated according to the generated column group information. Data is encoded or decoded based on the generated parity-check matrix.
    Type: Application
    Filed: November 24, 2009
    Publication date: September 15, 2011
    Applicant: Ecole Polytechnique Federale de Lausanne (EPFL)
    Inventors: James Brandon Dixon, Jeffrey A. Hubbell, Conlin P. O'Neil, Melody Swartz, Diana Velluto
  • Publication number: 20110206759
    Abstract: Chemokines may be administered to a patient for immunotolerization. Chemokines include CCL19 and CCL21. Materials and methods for accomplishing tolerization and described.
    Type: Application
    Filed: February 10, 2011
    Publication date: August 25, 2011
    Inventors: Melody A. Swartz, Jeffrey A. Hubbell, Alice A. Tomei, Jacqueline D. Shields, Iraklis Kourtis
  • Publication number: 20100055189
    Abstract: Nanoparticles that activate complement in the absence of biological molecules are described. The nanoparticles are shown to specifically target antigen presenting cells in specifically in lymph nodes, without the use of a biological molecule for targeting. These particles are useful vehicles for delivering immunotherapeutics. Surface chemistries and chemical formulations for the nanoparticles are described.
    Type: Application
    Filed: August 29, 2008
    Publication date: March 4, 2010
    Inventors: Jeffrey A. Hubbell, Conlin P. O'Neil, Sai T. Reddy, Melody A. Swartz, Diana Velluto, Andre van Der Vlies, Eleonora Simeoni
  • Publication number: 20080031899
    Abstract: Nanoparticles that activate complement in the absence of biological molecules are described. The nanoparticles are shown to specifically target antigen presenting cells in specifically in lymph nodes, without the use of a biological molecule for targeting. These particles are useful vehicles for delivering immunotherapeutics.
    Type: Application
    Filed: February 19, 2007
    Publication date: February 7, 2008
    Inventors: Sai Reddy, Jeffrey Hubbell, Melody Swartz, Andre Vlies