Patents by Inventor Meltem MUFTUOGLU

Meltem MUFTUOGLU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DNA polymerase gamma inhibitor and uses thereof
    Patent number: 11883419
    Abstract: Pol ? protein inhibitor compounds are useful for selectively inhibiting the growth of MLH1 mutant/deficient tumor or cancer cells due to a synthetic lethal relationship between MLH1 and Pol ?. The compounds were shown to directly interact with Pol ? and inhibit its biological function and cause cancer cell death and an inhibition of tumor or cancer cell growth in multiple assays.
    Type: Grant
    Filed: June 25, 2018
    Date of Patent: January 30, 2024
    Assignees: ACIBADEM MEHMET ALI AYDINLAR UNIVERSITESI, SABANCI UNIVERSITESI, KOC UNIVERSITESI
    Inventors: Meltem Muftuoglu, Batu Erman, Burak Erman
  • NOVEL DNA POLYMERASE GAMMA INHIBITOR AND USES THEREOF
    Publication number: 20210275548
    Abstract: Pol ? protein inhibitor compounds are useful for selectively inhibiting the growth of MLH1 mutant/deficient tumor or cancer cells due to a synthetic lethal relationship between MLH1 and Pol ?. The compounds were shown to directly interact with Pol ? and inhibit its biological function and cause cancer cell death and an inhibition of tumor or cancer cell growth in multiple assays.
    Type: Application
    Filed: June 25, 2018
    Publication date: September 9, 2021
    Applicants: ACIBADEM MEHMET ALI AYDINLAR UNIVERSITESI, SABANCI UNIVERSITESI, KOC UNIVERSITESI
    Inventors: Meltem MUFTUOGLU, Batu ERMAN, Burak ERMAN