Patents by Inventor Melvin E. Clouse

Melvin E. Clouse has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5753207
    Abstract: A method for measuring temperature and/or pH in vivo using paramagnetic compounds, e.g., lanthanide complexes, in conjunction with NMR has been developed. The chemical shift of the nuclear spin in these complexes can then be correlated to temperature. This non-invasive temperature measurement method is particularly useful in monitoring temperature of cancerous tissue during hyperthermic treatment to destroy the cancerous tissue or tumor.
    Type: Grant
    Filed: August 19, 1996
    Date of Patent: May 19, 1998
    Assignee: Beth Israel Deaconess Medical Center, Inc.
    Inventors: Chun S. Zuo, Melvin E. Clouse
  • Patent number: 5211658
    Abstract: A blood vessel wall-defining device and method for using the device for repairing an aneurysm.
    Type: Grant
    Filed: November 5, 1991
    Date of Patent: May 18, 1993
    Assignee: New England Deaconess Hospital Corporation
    Inventor: Melvin E. Clouse
  • Patent number: 5200400
    Abstract: Method for inhibiting acute rejection of a transplanted organ or tissue by a recipient mammal that includes the steps of administering to the mammal a compound which causes selective sensitization of the alloreactive lymphocytes of the transplant recipient that are involved in the rejection process to a toxin; and exposing the mammal to the toxin to selectively destroy the sensitized alloreactive lymphocytes to a greater extent than non-sensitized cells of the mammal. This method induces donor specific tolerance in the transplant recipient, i.e., acceptance of the new organ or tissue without suppression of the rest of the recipient's normal immune system.
    Type: Grant
    Filed: July 12, 1991
    Date of Patent: April 6, 1993
    Assignee: New England Deaconess Hospital Corporation
    Inventors: Kenichi Teramoto, Melvin E. Clouse