Abstract: A sanitary cover being easily affixed to the microphone or speaker portions of a telephone handset for preventing transmission of microscopic particles present on the handset therethrough. The sanitary cover is made of a single piece of material, such as a cloth, that is essentially flat and round and the peripheral edge of which is underfolded and a resilient rubber is sewn therein to convert the flat piece of material into a dome or cup-shaped piece, the peripheral edge of which is inwardly gathered and sufficiently resilient and so sized as to firmly hold onto the microphone or speaker portion of the telephone handset. The material may be impregnated with a sanitary or disinfectant material or aromatic material.