Patents by Inventor Melvin J. Swanson
Melvin J. Swanson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 8129159Abstract: The present invention relates to methods, reagents, and substrates that can be used for, for example, immobilizing biomolecules, such as nucleic acids and proteins. In an embodiment, the present invention relates to surfaces coated with a polymer according to the present invention. In an embodiment, the present invention relates to methods for thermochemically and/or photochemically attaching molecules to a surface at a high density.Type: GrantFiled: September 9, 2010Date of Patent: March 6, 2012Assignee: Surmodics, Inc.Inventors: Ronald F. Ofstead, Melvin J. Swanson, Dale G. Swan
-
Publication number: 20110009292Abstract: The present invention relates to methods, reagents, and substrates that can be used for, for example, immobilizing biomolecules, such as nucleic acids and proteins. In an embodiment, the present invention relates to surfaces coated with a polymer according to the present invention. In an embodiment, the present invention relates to methods for thermochemically and/or photochemically attaching molecules to a surface at a high density.Type: ApplicationFiled: September 9, 2010Publication date: January 13, 2011Applicant: SurModics, Inc.Inventors: Ronald F. Ofstead, Melvin J. Swanson, Dale G. Swan
-
Patent number: 7829317Abstract: The present invention relates to methods, reagents, and substrates that can be used for, for example, immobilizing biomolecules, such as nucleic acids and proteins. In an embodiment, the present invention relates to surfaces coated with a polymer according to the present invention. In an embodiment, the present invention relates to methods for thermochemically and/or photochemically attaching molecules to a surface at a high density.Type: GrantFiled: September 14, 2007Date of Patent: November 9, 2010Assignee: SurModics, Inc.Inventors: Ronald F. Ofstead, Melvin J. Swanson, Dale G. Swan
-
Patent number: 7691787Abstract: Method and reagent composition for covalent attachment of target molecules, such as nucleic acids, onto the surface of a substrate. The reagent composition includes groups capable of covalently binding to the target molecule. Optionally, the composition can contain photoreactive groups for use in attaching the reagent composition to the surface. The reagent composition can be used to provide activated slides for use in preparing microarrays of nucleic acids.Type: GrantFiled: July 9, 2002Date of Patent: April 6, 2010Assignee: SurModics, Inc.Inventors: Ralph A. Chappa, Sheau-Ping Hu, Dale G. Swan, Melvin J. Swanson, Patrick E. Guire
-
Publication number: 20090042742Abstract: The present invention relates to methods, reagents, and substrates that can be used for, for example, immobilizing biomolecules, such as nucleic acids and proteins. In an embodiment, the present invention relates to surfaces coated with a polymer according to the present invention. In an embodiment, the present invention relates to methods for thermochemically and/or photochemically attaching molecules to a surface at a high density.Type: ApplicationFiled: September 14, 2007Publication date: February 12, 2009Applicant: SurModics, Inc.Inventors: Ronald F. Ofstead, Melvin J. Swanson, Dale G. Swan
-
Patent number: 7309593Abstract: The present invention relates to methods, reagents, and substrates that can be used for, for example, immobilizing biomolecules, such as nucleic acids and proteins. In an embodiment, the present invention relates to surfaces coated with a polymer according to the present invention. In an embodiment, the present invention relates to methods for thermochemically and/or photochemically attaching molecules to a surface at a high density.Type: GrantFiled: October 1, 2003Date of Patent: December 18, 2007Assignee: SurModics, Inc.Inventors: Ronald F. Ofstead, Melvin J. Swanson, Dale G. Swan
-
Patent number: 7300756Abstract: Method and reagent composition for covalent attachment of target molecules, such as nucleic acids, onto the surface of a substrate. The reagent composition includes epoxide groups capable of covalently binding to the target molecule. Optionally, the composition can contain photoreactive groups for use in attaching the reagent composition to the surface.Type: GrantFiled: May 12, 2004Date of Patent: November 27, 2007Assignee: SurModics, Inc.Inventors: Dale G. Swan, Melvin J. Swanson
-
Patent number: 7137864Abstract: The invention provides controlled release compositions for treatment of parasitic mites in honeybees, the compositions composed of a covalently crosslinked polymer gel and an active agent that includes a salt of formic acid. The invention also provides methods for controlling parasitic mites in honeybees, the methods involving treating the honeybees with a controlled release composition composed a covalently crosslinked polymer gel and an active agent that includes a salt of formic acid. The invention further provides a kit for treatment of parasitic mites in honeybees, the kit including an envelope that contains a controlled release composition of the invention. Optionally, the active agent can include formic acid.Type: GrantFiled: July 12, 2004Date of Patent: November 21, 2006Inventor: Melvin J. Swanson
-
Publication number: 20040209305Abstract: Method and reagent composition for covalent attachment of target molecules, such as nucleic acids, onto the surface of a substrate. The reagent composition includes epoxide groups capable of covalently binding to the target molecule. Optionally, the composition can contain photoreactive groups for use in attaching the reagent composition to the surface. The reagent composition can be used to provide activated slides for use in preparing microarrays of nucleic acids.Type: ApplicationFiled: May 12, 2004Publication date: October 21, 2004Applicant: SurModics, Inc.Inventors: Dale G. Swan, Melvin J. Swanson
-
Patent number: 6762019Abstract: Method and reagent composition for covalent attachment of target molecules, such as nucleic acids, onto the surface of a substrate. The reagent composition includes epoxide groups capable of covalently binding to the target molecule. Optionally, the composition can contain photoreactive groups for use in attaching the reagent composition to the surface. The reagent composition can be used to provide activated slides for use in preparing microarrays of nucleic acids.Type: GrantFiled: March 9, 2000Date of Patent: July 13, 2004Assignee: SurModics, Inc.Inventors: Dale G. Swan, Melvin J. Swanson
-
Publication number: 20030181423Abstract: A polybifunctional reagent having a polymeric backbone, one or more pendent photoreactive moieties, and two or more pendent bioactive groups. The reagent can be activated to form a bulk material or can be brought into contact with the surface of a previously formed biomaterial and activated to form a coating. The pendent bioactive groups function by promoting the attachment of specific molecules or cells to the bulk material or coated surface. Bioactive groups can include proteins, peptides, carbohydrates, nucleic acids and other molecules that are capable of binding noncovalently to specific and complimentary portions of molecules or cells.Type: ApplicationFiled: February 3, 2003Publication date: September 25, 2003Inventors: David L. Clapper, Melvin J. Swanson, Sheau-Ping Hu, Richard A. Amos, Terrence P. Everson
-
Publication number: 20030170914Abstract: A system for producing substantially identical specific binding ligand (e.g., nucleic acid) probe arrays, for instance, by preparing and replicating an original master array and/or by providing a reusable assay array that is capable of being regenerated. In one embodiment the system includes the preparation and use of a) a master array surface having address sequences immobilized in the form of a patterned, and optionally random, array, b) a multi-ligand conjugate having a binding domain complementary to an address sequence, a binding domain complementary to a target sequence, and a third ligand for use in forming (e.g., by binding or polymerization) the conjugates into or onto the surface of assay array, which can be used with or upon disassociation of the address and its complementary sequences.Type: ApplicationFiled: February 3, 2003Publication date: September 11, 2003Applicant: SurModics, IncInventors: Patrick E. Guire, Melvin J. Swanson
-
Publication number: 20030148360Abstract: A system for producing substantially identical specific binding ligand probe arrays, for instance, by preparing and replicating an original master array and/or by providing a reusable assay array that is capable of being regenerated. In one embodiment the system includes the preparation and use of a) a master array surface having address ligands immobilized thereon, b) a multi-ligand conjugate having a binding domain complementary to an address ligand, a binding domain complementary to a target ligand, and a third ligand for use in transferring the conjugates into or onto the surface of assay array, which can be used with or upon disassociation of the address and its complementary ligands.Type: ApplicationFiled: January 15, 2003Publication date: August 7, 2003Applicant: SurModics, Inc.Inventors: Patrick E. Guire, Melvin J. Swanson
-
Publication number: 20030148308Abstract: Method and reagent composition for covalent attachment of target molecules, such as nucleic acids, onto the surface of a substrate. The reagent composition includes groups capable of covalently binding to the target molecule. Optionally, the composition can contain photoreactive groups for use in attaching the reagent composition to the surface. The reagent composition can be used to provide activated slides for use in preparing microarrays of nucleic acids.Type: ApplicationFiled: July 9, 2002Publication date: August 7, 2003Applicant: SurModics, Inc.Inventors: Ralph A. Chappa, Sheau-Ping Hu, Dale G. Swan, Melvin J. Swanson, Patrick E. Guire
-
Publication number: 20030113792Abstract: Method and reagent composition for covalent attachment of target molecules, such as nucleic acids, onto the surface of a substrate. The reagent composition includes epoxide groups capable of covalently binding to the target molecule. Optionally, the composition can contain photoreactive groups for use in attaching the reagent composition to the surface. The reagent composition can be used to provide activated slides for use in preparing microarrays of nucleic acids.Type: ApplicationFiled: March 9, 2000Publication date: June 19, 2003Inventors: Dale G. Swan, Melvin J. Swanson
-
Publication number: 20030082604Abstract: The invention provides a method for generating arrays with a variety of densities, in particular, high density arrays. Generally, the method includes a printing step and an illumination step. In the printing step, a predetermined volume of a reagent solution containing receptor molecules is applied to a solid support in a desired pattern. In one embodiment, the receptor molecule is derivatized with a photoreactive agent. In an alternate embodiment, the solid support includes a photoreactive agent. In a preferred embodiment, the receptor molecule is a nucleic acid. In the illumination step, the photoreactive groups are irradiated to immobilize the receptor molecule to the solid support. In one embodiment, a mask having the same center to center distance (e.g., pitch) as the printed spots, but a smaller diameter, is placed over the printed pattern and illuminated. Preferably the mask illuminates a spot having a smaller diameter than the printed spots.Type: ApplicationFiled: August 30, 2002Publication date: May 1, 2003Inventors: Melvin J. Swanson, Patrick E. Guire
-
Patent number: 6514734Abstract: A polybifunctional reagent is provided having a polymeric backbone, one or more pendent latent reactive (preferably photoreactive) moieties, and two or more pendent bioactive groups. The reagent can be activated to form a bulk material or can be brought into contact with the surface of a previously formed biomaterial and activated to form a coating. The pendent bioactive groups function by promoting the attachment of specific molecules or cells to the bulk material or coated surface. Bioactive groups can include proteins, peptides, carbohydrates, nucleic acids and other molecules that are capable of binding noncovalently to specific and complimentary portions of molecules or cells.Type: GrantFiled: June 9, 2000Date of Patent: February 4, 2003Assignee: Surmodics, Inc.Inventors: David L. Clapper, Melvin J. Swanson, Sheau-Ping Hu, Richard A. Amos, Terrence P. Everson
-
Patent number: 6514768Abstract: A system for producing substantially identical specific binding ligand (e.g., nucleic acid) probe arrays, for instance, by preparing and replicating an original master array and/or by providing a reusable assay array that is capable of being regenerated. In one embodiment the system includes the preparation and use of a) a master array surface having address sequences immobilized in the form of a patterned, and optionally random, array, b) a multi-ligand conjugate having a binding domain complementary to an address sequence, a binding domain complementary to a target sequence, and a third ligand for use in forming (e.g., by binding or polymerization) the conjugates into or onto the surface of assay array, which can be used with or upon disassociation of the address and its complementary sequences.Type: GrantFiled: January 29, 1999Date of Patent: February 4, 2003Assignee: Surmodics, Inc.Inventors: Patrick E. Guire, Melvin J. Swanson
-
Patent number: 6506895Abstract: A photoactivatable nucleic acid derivative composition in which one or more photoreactive group(s) are bound to a natural or synthetic nucleic acid. The photoreactive groups can be bound to the nucleic acid before, during or after its formation, and can thereafter be activated in order to attach the nucleic acid to another molecule, e.g., to the surface of a solid support. Also described is a method of preparing such a composition, and a method of using such a composition to attach the nucleic acid to a another molecule, such as that provided by the surface of a substrate used to prepare a nucleic acid chip by photolithographic techniques.Type: GrantFiled: February 24, 1998Date of Patent: January 14, 2003Assignee: SurModics, Inc.Inventors: Patrick E. Guire, Melvin J. Swanson, Gary W. Opperman
-
Patent number: 6465178Abstract: Method and reagent composition for covalent attachment of target molecules, such as nucleic acids, onto the surface of a substrate. The reagent composition includes groups capable of covalently binding to the target molecule. Optionally, the composition can contain photoreactive groups for use in attaching the reagent composition to the surface. The reagent composition can be used to provide activated slides for use in preparing microarrays of nucleic acids.Type: GrantFiled: January 8, 1999Date of Patent: October 15, 2002Assignee: Surmodics, Inc.Inventors: Ralph A. Chappa, Sheau-Ping Hu, Dale G. Swan, Melvin J. Swanson, Patrick E. Guire