Patents by Inventor Melvin Simon

Melvin Simon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pain signaling molecules
    Publication number: 20070196873
    Abstract: The invention relates generally to novel genes expressed in normal but not Neurogenin-1-deficient animals. The invention relates specifically to a novel family of G protein-coupled receptors and a novel family of two-transmembrane segment proteins that are expressed in dorsal root ganglia, and a method of screening for genes specifically expressed in nociceptive sensory neurons.
    Type: Application
    Filed: February 5, 2007
    Publication date: August 23, 2007
    Inventors: David Anderson, Xinzhong Dong, Mark Zylka, Sang-kyou Han, Melvin Simon
  • Method and device for regulating fluid flow in microfluidic devices
    Publication number: 20070134807
    Abstract: A method and a microfluidic device are provided to regulate fluid flow by equalization of channel pressures. The fluid flow is regulated by way of valve-actuated channel pressures.
    Type: Application
    Filed: October 27, 2006
    Publication date: June 14, 2007
    Inventors: Xiaoyan Bao, Stephen Quake, Melvin Simon
  • Promiscuous G-protein compositions and their use
    Publication number: 20060008855
    Abstract: Disclosed are compositions and methods for their use, such as in identifying G-protein coupled receptors and ligands and compounds that modulate signal transduction. The compositions and methods employ promicuous G-proteins. Activation of the promiscous G-protein can be detected in a variety of assays, including assays in which activation is indicated by a change in fluorescence emission of a sample that contains the composition.
    Type: Application
    Filed: September 16, 2005
    Publication date: January 12, 2006
    Inventors: Paul Negulescu, Stefan Offermanns, Melvin Simon, Charles Zuker
  • Pain signaling molecules
    Publication number: 20050208047
    Abstract: A novel G protein-coupled receptor called MrgC11 has been identified that is expressed in dorsal root ganglia and that is activated by RF amide related peptides.
    Type: Application
    Filed: April 27, 2005
    Publication date: September 22, 2005
    Inventors: David Anderson, Xinzhong Dong, Mark Zylka, Sang-Kyou Han, Melvin Simon
  • Pain signaling molecules
    Publication number: 20050164288
    Abstract: The invention relates generally to novel genes expressed in normal but not Neurogenin-1-deficient animals. The invention relates specifically to a novel family of G protein-coupled receptors and a novel family of two-transmembrane segment proteins that are expressed in dorsal root ganglia, and a method of screening for genes specifically expressed in nociceptive sensory neurons.
    Type: Application
    Filed: March 17, 2005
    Publication date: July 28, 2005
    Inventors: David Anderson, Xinzhong Dong, Mark Zylka, Sang-Kyou Han, Melvin Simon
  • Pain signaling molecules
    Publication number: 20050037468
    Abstract: The invention relates generally to novel genes expressed in normal but not Neurogenin-1-deficient animals. The invention relates specifically to a novel family of G protein-coupled receptors and a novel family of two-transmembrane segment proteins that are expressed in dorsal root ganglia, and a method of screening for genes specifically expressed in nociceptive sensory neurons.
    Type: Application
    Filed: September 30, 2004
    Publication date: February 17, 2005
    Inventors: David Anderson, Xinzhong Dong, Mark Zylka, Sang-kyou Han, Melvin Simon
  • Pain signaling molecules
    Publication number: 20040121410
    Abstract: A novel G protein-coupled receptor called MrgC11 has been identified that is expressed in dorsal root ganglia and that is activated by RF amide related peptides.
    Type: Application
    Filed: December 20, 2002
    Publication date: June 24, 2004
    Inventors: David J. Anderson, Xinzhong Dong, Mark Zylka, Sang-Kyou Han, Melvin Simon
  • Cobalt Schiff base compounds
    Patent number: 6008190
    Abstract: The invention relates to novel cobalt compounds, having a general structure ##STR1## wherein Co is either Co(II) or Co(III), and each of the R groups is selected from the group consisting of hydrogen, alkyl, hydrophilic organic acid, alkyl amine, amine, alkyl alcohol, alcohol, polypeptide or nucleic acid. The invention further relates to methods of using such compounds to reduce the biological activity of proteins, particularly enzymes and zinc finger-containing proteins.
    Type: Grant
    Filed: December 12, 1995
    Date of Patent: December 28, 1999
    Assignee: California Institute of Technology
    Inventors: Thomas J. Meade, Toshihiko Takeuchi, Harry B. Gray, Melvin Simon, Angelique Y. Louie
  • Promiscuous G-protein compositions and their use
    Patent number: 6004808
    Abstract: Disclosed are compositions and methods for their use, such as in identifying G-protein coupled receptors and ligands and compounds that modulate signal transduction. The compositions and methods employ promicuous G-proteins. Activation of the promiscous G-protein can be detected in a variety of assays, including assays in which activation is indicated by a change in fluorescence emission of a sample that contains the composition.
    Type: Grant
    Filed: June 19, 1997
    Date of Patent: December 21, 1999
    Assignee: Aurora BioSciences Corporation
    Inventors: Paul Negulescu, Stefan Offermanns, Melvin Simon, Charles Zuker
  • Oversized iron-type golf club head
    Patent number: D603918
    Type: Grant
    Filed: December 23, 2008
    Date of Patent: November 10, 2009
    Assignee: Simon Golf Company, LLC
    Inventors: Melvin Simon, Brian Symonds