Patents by Inventor Melvyn Hollis

Melvyn Hollis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Regulation of gene expression
    Patent number: 5554510
    Abstract: The present invention relates to the regulation of gene expression which entails providing a pair of unlike proteins, with unlike DNA binding domains, which will associate to form a heterodimer and bind to appropriate asymmetric DNA binding sites and hence depress or increase expression of adjacent genes.
    Type: Grant
    Filed: December 1, 1993
    Date of Patent: September 10, 1996
    Assignees: Imperial Chemical Industries, PLC, President and Fellows of Harvard College
    Inventors: Melvyn Hollis, David Pioli, Dario Valenzuela
  • Expression systems
    Patent number: 5538885
    Abstract: Expression systems which comprise a mammalian host, such as erythroid cells, transformed with a vector which comprises a promoter, a DNA sequence which codes for a desired polypeptide and a dominant control region. The vectors and methods for preparing polypeptides using the expression systems are also described. In a preferred embodiment, the vector contains cDNA for the desired polypeptide and a sequence which is capable of stabilising mRNA produced from the cDNA. The expression systems are particularly efficient and are capable of secreting the desired polypeptide.
    Type: Grant
    Filed: January 27, 1994
    Date of Patent: July 23, 1996
    Assignee: Imperial Chemical Industries PLC
    Inventors: Melvyn Hollis, Maurice R. C. Needham, Clare Gooding, Franklin G. Grosveld, Michael Antoniou