Patents by Inventor Melvyn N. Kronick

Melvyn N. Kronick has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5443791
    Abstract: A liquid-handling instrument has a worksurface with registration for modular stations to support containers of liquid, pipette apparatus with a pipette tip coupled to a sensing circuit, a robotic translation system for moving the pipette tip, and a control system with an iconic user interface for programming and editing. A gauge block registered on the worksurface provides for calibration using the sensing tip, and register cavities on the worksurface provide for modular stations. There is a wash station fop the pipette tip on the worksurface. An automated laboratory based on the liquid-handling system has heating and cooling and a sealable incubation station as well as a magnetic separation station. Methods are disclosed using the apparatus to convey droplets of liquid, to aspirate with minimum tip contamination, to mix liquids in containers, and to validate the worksurface.
    Type: Grant
    Filed: August 7, 1992
    Date of Patent: August 22, 1995
    Assignee: Perkin Elmer - Applied Biosystems Division
    Inventors: G. Richard Cathcart, Thomas Brennan-Marquez, John A. Bridgham, George S. Golda, Harry A. Guiremand, Marianne Hane, Louis B. Hoff, Eric Lachenmeier, Melvyn N. Kronick, Douglas H. Keith, Paul E. Mayrand, Michael L. Metzker, William J. Mordan, Lincoln J. McBride, John Shigeura, Chen-Hanson Ting, Norman M. Whiteley
  • Patent number: 4192996
    Abstract: A device is provided for measuring the concentration of oxygen in a sample utilizing the differential absorption by oxygen (O.sub.2) of two closely spaced ultraviolet (UV) radiation lines. The two UV lines are preferably isotope-shifted Hg lines in the vicinity of the Hg atomic transistion line at 1849.5A.
    Type: Grant
    Filed: July 12, 1978
    Date of Patent: March 11, 1980
    Assignee: Hewlett-Packard Company
    Inventors: Melvyn N. Kronick, Charles E. Bryson, III, John A. Bridgham, Sam H. Eletr
  • Patent number: 3939350
    Abstract: Receptors are employed to which one or more fluroescent molecules are bound. When the receptors are bound to the epitopic sites on the surface and light of predetermined wave length is directed toward the surface, the fluorescing molecules are activated and fluoresce.In carrying out an assay, receptor is combined with an unknown suspected of containing molecules having the same epitopic sites bound to the surface. The receptor will bind to these molecules reducing the number of receptor sites available for binding to the epitopic sites on the surface. When the assay medium is contacted with the surface, the amount of receptor which binds to the surface, will be a function of available binding sites and, therefore, to the number of the molecules present in the unknown. Upon irradiation of the surface, substantially only the fluoroescent molecules bound to the surface will fluoresce. By monitoring the fluorescence, one can determine the presence and number of molecules of interest present in the unknown.
    Type: Grant
    Filed: April 29, 1974
    Date of Patent: February 17, 1976
    Assignee: Board of Trustees of the Leland Stanford Junior University
    Inventors: Melvyn N. Kronick, William A. Little