Patents by Inventor Melwyn Abreo
Melwyn Abreo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 7754711Abstract: Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (Ia): where x, y, W, V, R2, R3, R4, R5, R6, R6a, R7, R7a, R8, R8a, R9 and R9a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.Type: GrantFiled: February 9, 2005Date of Patent: July 13, 2010Assignee: Xenon Pharmaceuticals Inc.Inventors: Nagasree Chakka, Mikhail Chafeev, Sultan Chowdhury, Jian-Min Fu, Duanjie Hou, Rajender Kamboj, Vishnumurthy Kodumuru, Shifeng Liu, Vandna Raina, Shaoyi Sun, Serguei Sviridov, Michael D. Winther, Zaihui Zhang, Melwyn Abreo, Mark W. Holladay, Wenbao Li, Sengen Sun, Chi Tu, Heinz W. Gschwend
-
Publication number: 20100048584Abstract: Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): wherein x, y, W, V, R1, R2, R3, R4, R5, R6, R7, R7a, R8, R8a, R9, R9a, R10 and R10a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.Type: ApplicationFiled: September 2, 2009Publication date: February 25, 2010Applicant: XENON PHARMACEUTICALS INC.Inventors: Melwyn Abreo, Daniel F. Harvey, Heinz W. Gschwend, Wenbao Li, Chi Tu, Rajender Kamboj, Michael D. Winther, Vishnumurthy Kodumuru, Cindy J. Hudson, Mikhail A. Kondratenko, Shifeng Liu, Vandna Raina, Serguei Sviridov, Zaihui Zhang, Mehran Seid Bagherzadeh, Shaoyi Sun
-
Patent number: 7605161Abstract: Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): wherein: W is —O—, —N(R1)—, C(O), S(O)t; (where t is 0, 1 or 2), N(R1)S(O)2, S(O)2N(R1), C(O)N(R1) or N(R1)C(O)N(R1); and V is C(O), C(S), C(O)N(R1)—, C(O)O—, S(O)2—, S(O)2N(R1)— or C(R11)H; and x, y, R1, R2, R3, R4, R5, R6, R7, R7a, R8, R8a, R9, R9a, R10 and R10a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.Type: GrantFiled: July 29, 2004Date of Patent: October 20, 2009Assignee: Xenon Pharmaceuticals Inc.Inventors: Melwyn Abreo, Daniel F. Harvey, Heinz W. Gschwend, Wenbao Li, Chi Tu, Rajender Kamboj, Michael D. Winther, Vishnumurthy Kodumuru, Cindy J. Hudson, Mikhail A. Kondratenko, Shifeng Liu, Vandna Raina, Serguei Sviridov, Zaihui Zhang, Mehran Seid Bagherzadeh, Shaoyi Sun
-
Patent number: 7592445Abstract: This invention is directed to compounds of Formulae III and V, useful for treating diseases or conditions associated with platelet aggregation.Type: GrantFiled: January 4, 2008Date of Patent: September 22, 2009Assignee: Inspire Pharmaceuticals, Inc.Inventors: Robert Plourde, Jr., Sammy R. Shaver, James G. Douglass, III, Paul S. Watson, José L. Boyer, Chi Tu, Melwyn A. Abreo, Lorenzo J. Alfaro-Lopez, Yangbo Feng, Daniel F. Harvey, Tatyana V. Khasonova
-
Publication number: 20090131447Abstract: This invention is directed to the use of SCD-1 inhibitors of the formula (I): where x, y, V, W, G, J, L, M, R2, R3, R5, R5a, R6, R6a, R7, R7a, R8 and R8a are defined herein, in combination with other drug therapies to treat adverse weight gain.Type: ApplicationFiled: February 8, 2006Publication date: May 21, 2009Applicant: XENON PHARMACEUTICALS INC.Inventors: Rajender Kamboj, Michael D. Winther, Robert Fraser, Mikhail Chafeev, Sultan Chowdhury, Jian-Min Fu, Duanjie Hou, Shifeng Liu, Vandna Raina, Mehran Seid Bagherzadeh, Serguei Sviridov, Kashinath Sadalapure, Shaoyi Sun, Vishnumurthy Kodumuru, Nagasree Chakka, Zaihui Zhang, Melwyn Abreo, Mikhail A. Kondratenko, Daniel F. Harvey, Cindy J. Hudson, Wenbao Li, Chi Tu, Sengen Sun, Mark W. Holladay, Heinz W. Gschwend
-
Publication number: 20090030008Abstract: Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where G, J, L, M, x, y, W, V, R2, R3, R4, R5, R6, R7, R8, R8a, R9, R9a, R10, R10a, R11 and R11a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.Type: ApplicationFiled: October 8, 2008Publication date: January 29, 2009Applicant: XENON PHARMACEUTICALS INC.Inventors: Serguei Sviridov, Vishnumurthy Kodumuru, Shifeng Liu, Melwyn Abreo, Michael D. Winther, Heinz W. Gschwend, Rajender Kamboj, Shaoyi Sun, Mark W. Holladay, Wenbao Li, Chi Tu
-
Patent number: 7456180Abstract: Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where G, J, L, M, x, y, W, V, R2, R3, R4, R5, R6, R7, R8, R8a, R9, R9a, R10, R10a, R11 and R11a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.Type: GrantFiled: July 29, 2004Date of Patent: November 25, 2008Assignee: Xenon Pharmaceuticals Inc.Inventors: Serguei Sviridov, Vishnumurthy Kodumuru, Shifeng Liu, Melwyn Abreo, Michael D. Winther, Heinz W. Gschwend, Rajender Kamboj, Shaoyi Sun, Mark W. Holladay, Wenbao Li, Chi Tu
-
Patent number: 7368438Abstract: This invention is directed to a method of preventing or treating diseases or conditions associated with platelet aggregation. The method is also directed to a method of treating thrombosis or related disorders. The method comprises administering to a subject a pharmaceutical composition comprising an effective amount of a non-nucleotide compound, preferably a P2Y12 receptor antagonist compound, wherein said amount is effective to inhibit platelet aggregation. The compounds useful for this invention include compounds of general Formula I and III-XI, or salts, hydrates, and solvates thereof. The present invention also provides novel compounds according to Formula I and III-XI.Type: GrantFiled: October 21, 2004Date of Patent: May 6, 2008Assignee: Inspire Pharmaceuticals, Inc.Inventors: Robert Plourde, Jr., Sammy R. Shaver, José L. Boyer, Melwyn A. Abreo, Lorenzo J. Alfaro-Lopez, Yangbo Feng, Daniel F. Harvey, Tatyana V. Khasonova, Chi Tu
-
Publication number: 20080103304Abstract: This invention is directed to a method of preventing or treating diseases or conditions associated with platelet aggregation. The method is also directed to a method of treating thrombosis or related disorders. The method comprises administering to a subject a pharmaceutical composition comprising an effective amount of a non-nucleotide compound, preferably a P2Y12 receptor antagonist compound, wherein said amount is effective to inhibit platelet aggregation. The compounds useful for this invention include compounds of general Formulae I and III-XII, or salts, hydrates, and solvates thereof. The present invention also provides novel compounds of Formulae I and III-XII.Type: ApplicationFiled: January 4, 2008Publication date: May 1, 2008Inventors: Robert Plourde, Sammy Shaver, James Douglass, Paul Watson, Jose Boyer, Chi Tu, Melwyn Abreo, Lorenzo Alfaro-Lopez, Yangbo Feng, Daniel Harvey, Tatyana Khasonova
-
Patent number: 7335658Abstract: Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where x, y, W, V, R2, R3, R4, R5, R6, R6a, R7, R7a, R8, R8a, R9 and R9a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.Type: GrantFiled: July 29, 2004Date of Patent: February 26, 2008Assignee: Xenon Pharmaceuticals Inc.Inventors: Nagasree Chakka, Mikhail Chafeev, Sultan Chowdhury, Jian-Min Fu, Duanjie Hou, Rajender Kamboj, Vishnumurthy Kodumuru, Shifeng Liu, Vandna Raina, Shaoyi Sun, Serguei Sviridov, Michael D Winther, Zaihui Zhang, Melwyn Abreo, Mark W Holladay, Wenbao Li, Sengen Sun, Chi Tu, Heinz W Gschwend
-
Patent number: 7335648Abstract: This invention is directed to a method of preventing or treating diseases or conditions associated with platelet aggregation. The method is also directed to a method of treating thrombosis or related disorders. The method comprises administering to a compounds useful for this invention include compounds of general Formulae I and III-XII, or salts, hydrates, and solvates thereof. The present invention also provides novel compounds of Formulae I and III-XII.Type: GrantFiled: May 5, 2005Date of Patent: February 26, 2008Assignee: Inspire Pharmaceuticals, Inc.Inventors: Robert Plourde, Jr., Sammy R. Shaver, James G. Douglass, III, Paul S. Watson, José L. Boyer, Chi Tu, Melwyn A. Abreo, Lorenzo J. Alfaro-Lopez, Yangbo Feng, Daniel F. Harvey, Tatyana V. Khasonova
-
Publication number: 20070123544Abstract: The present invention is directed to a method of treating pain. The method comprises administering to a subject a pharmaceutical composition comprising an effective amount of a P2X receptor antagonist. The methods of the present invention are useful in reducing pain, such as traumatic pain, neuropathic pain, organ pain and/or pain associated with diseases. The P2X receptor antagonists useful for this invention are non-nucleotide compounds of general Formula I. Compounds of Formula I can be used alone to treat pain. Compounds of Formula I can also be used in conjunction with other therapeutic agents or adjunctive therapies commonly used to treat pain, thus enhancing the therapeutic effect of pain reduction.Type: ApplicationFiled: October 21, 2004Publication date: May 31, 2007Inventors: Robert Plourde, Sammy Shaver, Melwyn Abreo, Lorenzo Alfaro-Lopez, Yangho Feng, Tatyana Khasanova, Mark Holladay, Christopher Crean
-
Publication number: 20060293308Abstract: Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): wherein W, V, x, y, R1, R2, R3, R4, R5, R6, R7, R7a, R8, R8a, R9, R9a, R10 and R10a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.Type: ApplicationFiled: July 29, 2004Publication date: December 28, 2006Applicant: Xenon Pharmaceuticals Inc.Inventors: Melwyn Abreo, Daniel Harvey, Mikhail Kondratenko, Wenbao Li, Rajender Kamboj, Vishnumurthy Rodumuru, Michael Winther, Heinz Gschwend, Nagasres Chakka, Shifeng Liu, Serguei Sviridov, Shaoyi Sun
-
Publication number: 20060252767Abstract: Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where G, J, L, M, x, y, W, V, R2, R3, R4, R5, R6, R7, R8, R8a, R9, R9a, R10, R10a, R11 and R11a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.Type: ApplicationFiled: July 29, 2004Publication date: November 9, 2006Applicant: XENON PHARMACEUTICALS INC.Inventors: Serguei Sviridov, Vishnumurthy Kodumuru, Shifeng Liu, Melwyn Abreo, Michael Winther, Heins Gschwend, Rajender Kamboj, Shaoyi Sun, Mark Holladay, Wenbao Li, Chi Tu
-
Patent number: 7115658Abstract: Compounds of formula I are hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp) inhibitors, and are useful in therapeutic and prophylactic treatment of persons infected with hepatitis C virusType: GrantFiled: May 9, 2003Date of Patent: October 3, 2006Assignee: Agouron Pharmaceuticals, Inc.Inventors: Allen J. Borchardt, Peter Scott Dragovich, Javier Gonzalez, Tanya Michelle Jewell, Hui Li, Maria Angelica Linton, John Howard Tatlock, Ru Zhou, Thomas Jay Prins, Melwyn A. Abreo
-
Publication number: 20060199802Abstract: Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (1): wherein: W is —O—, —N(R1)—, C(O), S(O)t ; (where t is 0, 1 or 2), N(R1)S(O)2, S(O)2N(R1) , C(O)N(R1) or N(R1)C(O)N(R1); and V is C(O), C(S), C(O)N(R1)—, C(O)O—, S(O)2—, S(O)2N(R1)— or C(R1)H; and x, y, R1, R2, R3, R4, R5, R6, R7, R7a, R8, R8a, R9, R9a, R10 and R10a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.Type: ApplicationFiled: July 29, 2004Publication date: September 7, 2006Inventors: Melwyn Abreo, Daniel Harvey, Heins Gschwend, Wenbao Li, Chi Tu, Rajender Kamboj, Michael Winther, Vishnumurthy Kodumuru, Cindy Hudson, Mikhail Kondratenko, Shifeng Liu, Vandna Raina, Serguei Sviridov, Zaihui Zhang, Mehran Seid Bagherzadeh, Shaoyi Sun
-
Publication number: 20060009459Abstract: Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (Ia): where x, y, W, V, R2, R3, R4, R5, R6, R6a, R7, R7a, R8, R8a, R9 and R9a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.Type: ApplicationFiled: February 9, 2005Publication date: January 12, 2006Inventors: Nagasree Chakka, Mikhail Chafeev, Sultan Chowdhury, Jian-Min Fu, Duanjie Hou, Rajender Kamboj, Vishnumurthy Kodumuru, Shifeng Liu, Vandna Raina, Shaoyi Sun, Serguei Sviridov, Michael Winther, Zaihui Zhang, Melwyn Abreo, Mark Holladay, Wenbao Li, Sengen Sun, Chi Tu, Heinz Gschwend
-
Publication number: 20050267134Abstract: This invention is directed to a method of preventing or treating diseases or conditions associated with platelet aggregation. The method is also directed to a method of treating thrombosis or related disorders. The method comprises administering to a subject a pharmaceutical composition comprising an effective amount of a non-nucleotide compound, preferably a P2Y12 receptor antagonist compound, wherein said amount is effective to inhibit platelet aggregation, preferably in a reversible manner. The compounds useful for this invention include compounds of general Formulae I and III-XII, or salts, hydrates, and solvates thereof. The present invention also provides novel compounds of Formulae I and III-XII.Type: ApplicationFiled: May 5, 2005Publication date: December 1, 2005Inventors: Robert Plourde,, Sammy Shaver, James Douglass,, Paul Watson, Jose Boyer, Chi Tu, Melwyn Abreo, Lorenzo Alfaro-Lopez, Yangbo Feng, Daniel Harvey, Tatyana Khasanova
-
Patent number: 6964957Abstract: Pyrazole compounds represented by the formula: are described. The pyrazole compounds and pharmaceutical compositions containing them may be used in inhibiting ERAB or HADH2 activity and in treating ERAB, HADH2 or amyloid-? mediated diseases and conditions.Type: GrantFiled: August 17, 2001Date of Patent: November 15, 2005Assignee: Agouron Pharmaceuticals, Inc.Inventors: Melwyn A. Abreo, Jerry J. Meng, Charles S. Agree
-
Publication number: 20050159388Abstract: This invention is directed to a method of preventing or treating diseases or conditions associated with platelet aggregation. The method is also directed to a method of treating thrombosis or related disorders. The method comprises administering to a subject a pharmaceutical composition comprising an effective amount of a non-nucleotide compound, preferably a P2Y12 receptor antagonist compound, wherein said amount is effective to inhibit platelet aggregation. The compounds useful for this invention include compounds of general Formulae I and III-XI, or salts, hydrates, and solvates thereof. The present invention also provides novel compounds according to Formulae I and III-XI.Type: ApplicationFiled: October 21, 2004Publication date: July 21, 2005Inventors: Robert Plourde, Sammy Shaver, Melwyn Abreo, Lorenzo Alfaro-Lopez, Yangbo Feng, Daniel Harvey, Tatyana Khasanova, Chi Tu