Patents by Inventor Menek Goldstein

Menek Goldstein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Genetically modified tyrosine hydroxylase and uses thereof
    Patent number: 5300436
    Abstract: Modification of the DNA encoding the enzyme tyrosine hydroxylase (TH) resulting in amino acid substitution in one of the first fifty five N-terminal residues, in particular replacing Ser-40 with Tyr or Leu, produced TH variants having substantially increased enzymatic activity upon transfection of suitable host cells. Cells transfected with the variant TH having enhanced enzymatic activity are useful for treating neurological or psychiatric disorders associated with deficient TH or dopamine, in particular Parkinson's disease, by grafting such cells into the brain.
    Type: Grant
    Filed: January 26, 1993
    Date of Patent: April 5, 1994
    Assignee: New York University
    Inventors: Menek Goldstein, Jing Wu, David Filer, Arnold J. Friedhoff
  • Genetically modified tyrosine hydroxylase and uses thereof
    Patent number: 5212082
    Abstract: Modification of the DNA encoding the enzyme tyrosine hydroxylase (TH) resulting in amino acid substitution in one of the first fifty five N-terminal residues, in particular replacing Ser-40 with Tyr or Leu, produced TH variants having substantially increased enzymatic activity upon transfection of suitable host cells. Cells transfected with the variant TH having enhanced enzymatic activity are useful for treating neurological or psychiatric disorders associated with deficient TH or dopamine, in particular Parkinson's disease, by grafting such cells into the brain.
    Type: Grant
    Filed: March 13, 1991
    Date of Patent: May 18, 1993
    Assignee: New York University
    Inventors: Menek Goldstein, Jing Wu, David Filer, Arnold J. Friedhoff