Abstract: The present invention refers to a three-dimensional porous hybrid scaffold for tissue engineering and methods of its manufacture and use.

Abstract: The present invention relates to a method for producing a contractile cellular construct, comprising the steps of: a) seeding pre-selected cells onto a mold, wherein the pre-selected cells comprise signal emitting agents; and b) culturing the pre-selected cells to produce the cellular construct. The said method is exemplified by mixing cardiomyocytes with fluorescent microbeads, seeding the suspension on a polydimethylsiloxane (PDMS) mold and culturing to form a contractile device comprising of cardiac muscles. The present invention also relates to a method for measuring the contractility of the cellular construct by measuring the displacement of the signal emitting agents, and a method for screening a method for screening one or more agents for modulating the contractility of a contractile cellular construct.

Abstract: In one example, the present invention refers to a method of making or producing a self-supporting cellular construct having a continuous channel within its central cavity, comprising the steps of providing a mould with a central opening, wherein the mould encloses a volume around the central opening (hole) capable of housing a plurality of cells. Each of the plurality of self-supporting cellular constructs, having a central opening in a series adjacent to one another such, is placed so that the central opening of each of the self-supporting cellular constructs having a central opening is aligned to one another to thereby form, for example, a continuous channel within its central cavity.

Abstract: There is provided a device, and related method and uses, for drawing a polymer fiber, the device comprising: a. at least two polymer compartments, wherein each polymer compartment is capable of retaining a polymer solution, and wherein adjacent compartments comprise different polymer solutions; and b. a slider comprising at least one prong, wherein the prong is capable of contacting the different polymer solutions, and wherein the slider is arranged in a retractable manner from the at least two polymer compartments. There is further provided a system and a related method for manufacturing a polymer fiber.

Abstract: A fibrous structure comprising an assembly of hair follicle cells within a fibrous matrix.

Abstract: The present invention refers to an apparatus and a method for the manufacture of a three-dimensional scaffold at low temperatures and the respective use of this method and apparatus.

Abstract: There is provided a device, and related method and uses, for drawing a polymer fiber, the device comprising: a. at least two polymer compartments, wherein each polymer compartment is capable of retaining a polymer solution, and wherein adjacent compartments comprise different polymer solutions; and b. a slider comprising at least one prong, wherein the prong is capable of contacting the different polymer solutions, and wherein the slider is arranged in a retractable manner from the at least two polymer compartments. There is further provided a system and a related method for manufacturing a polymer fiber.

Abstract: A fibrous structure comprising an assembly of hair follicle cells within a fibrous matrix.

Abstract: A fibrous structure comprising an assembly of hair follicle cells within a fibrous matrix.

Abstract: The present invention relates to a fiber-assembled tissue construct comprising at least one sinusoid unit, the unit comprising at least two polymeric fibers arranged in a sinusoid structure and fused together, each of said fibers comprising a porous matrix supporting biological components encapsulated in the fiber, wherein the biological components are patterned in three-dimensions within the construct.

Abstract: The present invention refers to a three-dimensional porous hybrid scaffold for tissue engineering and methods of its manufacture and use.

Abstract: The present invention refers to an apparatus and a method for the manufacture of a three-dimensional scaffold at low temperatures and the respective use of this method and apparatus.