Abstract: The compounds represented by Formula (I), which are peripheral alkyl and alkenyl chains extended benzene derivatives, are useful as dual autotaxin (ATX)/histone deacetylase (HD AC) inhibitors. These compounds may be included in a pharmaceutical composition along with a pharmaceutically acceptable carrier, and be used in a therapeutically effective amount for prophylaxis or treatment of various diseases and disorders.

Abstract: A bone fixing device includes a tubular member that has an end having an inside surface defining a constraint section. A fixing member has opposite ends respectively forming a movable joint section that is receivingly engageable with the constraint section and a threaded section that is attachable to a bone or a retention section that is snap-fit over a bone. The movable joint section forms a constraint face corresponding to the constraint section. The constraint section and the constraint face collectively constrain a swing direction of the fixing member. The movable joint section has a top end with which a constraint member is abuttingly engageable. Further, the tubular member forms an elongate constraint slot in a portion adjacent to the constraint section for constraining swing angle of the fixing member. The constraint slot has a length that is proportional to the swing angle of the fixing member.

Abstract: A textured bone graft or implant device includes a spatial member having a number of three dimensional units coupled together, the three dimensional units each include a number of bars coupled together to form a number of openings and to form a porous structure for the spatial member and for allowing the bone materials of the user to be grown and filled into the openings of the textured implant device, the spatial member includes a chamber for engaging with a casing, and the casing includes a compartment for engaging with an inner core, the casing and the inner core each include a number of bars for forming a resilient or flexible or compressible or deformable structure.

Abstract: A spinal implant in one embodiment includes an implant for insertion between two opposite spaced vertebrae of a spine, comprising an upper section having a substantially rectangular cross section and comprising a toothed top retaining member and a peripheral surface; a lower section having a substantially rectangular cross section and comprising a toothed bottom retaining member and a peripheral surface; an intermediate padding member for fastening the upper section and the lower section together; two three-dimensional matrix structures formed in the upper section and the lower section respectively and on the peripheral surfaces of the upper section and the lower section respectively as support; and a plurality of holes formed through at least one of three directions of each of the three-dimensional matrix structures.

Abstract: A spinal implant in one embodiment includes an implant for insertion between two opposite spaced vertebrae of a spine, comprising a body having a substantially rectangular cross section and comprising a toothed top retaining member, a toothed bottom retaining member, and a peripheral surface; a three-dimensional matrix structure formed in the body and on the peripheral surface as support; and a plurality of holes formed through at least one of three directions of the three-dimensional matrix structure.

Abstract: A hook structure includes a base and a movable hook which is fixed on the base and is provided with a hook board and a hook board seat that are mutually assembled. An elastic member is provided between the hook board and the hook board seat. By the elastic member, when the hook is collided by an external force, the elastic member will operate the hook board to be ejected back, allowing the present invention to be provided with an advantage of a hidden-type and collision-proofed hook.

Abstract: A hook structure includes a base and a movable hook which is fixed on the base and is provided with a hook board and a hook board seat that are mutually assembled. An elastic member is provided between the hook board and the hook board seat. By the elastic member, when the hook is collided by an external force, the elastic member will operate the hook board to be ejected back, allowing the present invention to be provided with an advantage of a hidden-type and collision-proofed hook.

Abstract: A door latching device includes a hook member, a housing, a slider slidably received in the housing and having one end for being depressed by the hook member, a latch member having a pivot axle rotatably engaged with the housing and pivotally coupled to the slider for allowing the latch member to be rotated relative to the housing by the slider, and a pawl rotatably attached to the slider for selectively positioning the slider at an intermediate position of the chamber of the housing and for maintaining the latch member at the second position which is disengaged from the hook member and for allowing the door panel to be easily anchored to or disengaged from the wall member without bending down the users' bodies.