Patents by Inventor Meng-Jer Lee

Meng-Jer Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TY-52156 COMPOUNDS FOR THE TREATMENT OF CANCER
    Publication number: 20190117596
    Abstract: TY-52156 compounds for the treatment of lung cancers and cancers mediated by KRAS gene mutations and/or TGF-?/Smad3 signaling are described. TY-52156 compounds antagonize sphingosine-1-phosphate receptor subtype 3 (S1PR3). Methods and kits for selecting subjects for particular treatments and/or clinical trials are also described.
    Type: Application
    Filed: April 28, 2017
    Publication date: April 25, 2019
    Applicant: WAYNE STATE UNIVERSITY
    Inventors: Meng-Jer Lee, Jiawei Zhao
  • Method for regulating angiogenesis
    Publication number: 20020142982
    Abstract: Methods for the inhibition of angiogenesis are presented, comprising affecting the response of the EDG-1 receptor by the administration of pharmaceutically effective antagonists of EDG-1 signal transduction. This invention is based in part on the discovery that Akt protein kinase phosphorylation is required for endothelial cell chemotaxis mediated by the EDG-1 G protein-coupled receptor. This invention relates to the use of modifiers of EDG-1 signal transduction to treat disorders of undesired angiogenesis.
    Type: Application
    Filed: August 31, 2001
    Publication date: October 3, 2002
    Inventors: Timothy Hla, Meng-Jer Lee, Kevin P. Claffey, Nicolas Ancellin, Shobha Thangada