Patents by Inventor Meng Koon Sim

Meng Koon Sim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of des-Aspartate-angiotensin I as an agent for the treatment and prevention of neointima formation, restenosis, and arteriosclerosis
    Patent number: 6100237
    Abstract: The use of des-Aspartate-angiotensin I (Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu) as an anti-neointima and anti-arteriosclerotic agent was described. The compound, given intravenously attenuates the development of neointima formation in balloon catheter-injured carotid arteries of Sprague Dawley rats. The anti-neointima action was dose-dependent and the maximum effect was obtained with a dose of 10 pmoles/day given 2 days pre- and 13 days post-balloon catheterization. When given orally on a chronic basis at a dose of 0.9 mg/kg/day for 47 weeks, the compound significantly attenuates the development of arteriosclerosis in the spontaneously hypertensive rats. The anti-arteriosclerotic action was not blood pressure dependent.
    Type: Grant
    Filed: October 14, 1998
    Date of Patent: August 8, 2000
    Assignee: National University of Singapore
    Inventor: Meng Koon Sim