Abstract: The present disclosure relates to a pan-KRAS inhibitor compound represented by Formula (I), a pharmaceutical composition comprising the compound, and the use of the compound of Formula (I) for the prevention and/or treatment of cancer, tumors, inflammatory diseases, autoimmune diseases, or immune-mediated diseases.

Abstract: Provided are a compound having the structure of formula (I) for inhibiting Wnt pathway activity, a pharmaceutical composition comprising the compound, and use of the compound in prevention and/or treatment of cancers, tumors, inflammatory diseases, autoimmune diseases, or immune-mediated diseases.

Abstract: Provided are a compound of Formula (I) and a pharmaceutical composition thereof, as well as a method for using the compounds of Formula (I) to prevent and/or treat immune-related disorders.

Abstract: Provided are a medicament-coated balloon coating solution, a coating material, a medicament-coated balloon, a preparation method therefor, and use thereof. The medicament-coated balloon coating solution comprises an aqueous-phase solvent. The coating solution further comprises a plurality of core-shell structures formed by wrapping a medicament in a phospholipid bilayer. The core-shell structures are dispersed in the aqueous-phase solvent. A core of each core-shell structure comprises a plurality of particles loaded with the medicament. A shell of each core-shell structure is the phospholipid bilayer. The phospholipid bilayer comprises a hydrophilic group in an outer layer and a hydrophobic group in an inner layer. The plurality of particles loaded with the medicament comprise a plurality of nanocrystalline particles comprising the medicament. Nanocrystalline is combined with liposome, such that advantages of two types of medicament carriers are combined.

Abstract: A point of interest (POI)-based information recommendation method and apparatus, an electronic device, and a computer-readable storage medium are provided. The method includes: determining an encircling region encircling a POI in an electronic map; using an original boundary of the encircling region as an inner boundary and performing expansion processing on the inner boundary, to obtain an outer boundary of the encircling region; determining candidate location relationships between a terminal device and the inner boundary and the outer boundary according to positioning data of the terminal device; determining a real-time state according to a historical state of the terminal device and the candidate location relationships, the real-time state being used for representing a location relationship between the terminal device and the inner boundary; and controlling, according to the real-time state, information about the POI outputted through a location service.

Abstract: A track anomaly detection method, performed by a computer device includes, acquiring a location to be detected in a moving track generated by a moving object; determining a target grid to which the location to be detected belongs from grids obtained by performing, based on an actual geographic area, gridding processing; determining at least one historical grid related to the moving object, the at least one historical grid being obtained based on a historical location, located within a preset time range, in the moving track generated by the moving object; and determining, according to a location relationship between the target grid and the at least one historical grid, an anomaly detection result of the moving track, transmitting, based on the anomaly detection result indicating the location to be detected is an abnormal location point, information to a terminal, to cause the terminal to display a warning prompt to a user.

Abstract: The present disclosure provides a compound of formula I or a pharmaceutically acceptable salt, isotope derivative, or stereoisomer thereof having excellent Wnt pathway inhibitory activity. The present disclosure also provides a method for preparing the compound and use of the compound in preventing and/or treating cancer, tumor, inflammatory disease, autoimmune disease or immune-mediated disease.

Abstract: The field is related to plant breeding and methods of identifying and selecting plants with resistance to southern com rust. Provided are methods to identify novel genes that encode proteins providing plant resistance to southern com rust and uses thereof. These disease resistant genes are useful in the production of resistant plants through breeding, transgenic modification, or genome editing.

Abstract: Embodiments of this application disclose an image processing method and apparatus, an electronic device, and a storage medium. The method includes obtaining a remaining mileage parameter of a vehicle; obtaining a start position of the vehicle on a map display interface; determining a target travel range on the map display interface according to the start position and the remaining mileage parameter; and displaying the target travel range on the map display interface.

Abstract: The field is related to plant breeding and methods of identifying and selecting plants with resistance to southern corn rust. Provided are methods to identify novel genes that encode proteins providing plant resistance to southern corn rust and uses thereof. These disease resistant genes are useful in the production of resistant plants through breeding, transgenic modification, or genome editing.

Abstract: Embodiments of this application disclose an image processing method and apparatus, an electronic device, and a storage medium. The method includes obtaining a remaining mileage parameter of a vehicle; obtaining a start position of the vehicle on a map display interface; determining a target travel range on the map display interface according to the start position and the remaining mileage parameter; and displaying the target travel range on the map display interface.

Abstract: A compound of formula (I) having the activity of inhibiting HPK1 kinase and a pharmaceutical composition comprising the compound. Also provided are the use of the compound in the prevention and/or treatment of cancers, tumors, inflammatory diseases, autoimmune diseases or immune-mediated diseases.

Abstract: Provided are a compound having the structure of formula (I) for inhibiting Wnt pathway activity, a pharmaceutical composition comprising the compound, and use of the compound in prevention and/or treatment of cancers, tumors, inflammatory diseases, autoimmune diseases, or immune-mediated diseases.

Abstract: Some embodiments of the present disclosure relate to biometric characteristic detection technology, which provide a method and chip for biometric characteristic acquisition, and a computer readable storage medium. The method for biometric characteristic acquisition includes: acquiring a plurality of configuration parameters, where the plurality of configuration parameters include a first exposure duration, parameters defining a first region and a target photosensitive value, where the first region is a local region in a photosensitive region of the chip for biometric characteristic acquisition; exposing the first region according to the first exposure duration, and acquiring a photosensitive value of the first region; determining a second exposure duration required to acquire the target photosensitive value in the photosensitive region according to the photosensitive value of the first region and the first exposure duration; and acquiring a biometric image according to the second exposure duration.

Abstract: A message pushing method, a storage medium, and a server are disclosed in this disclosure, belonging to the field of Internet of Vehicles. The method includes: obtaining basic data associated with a target vehicle; recognizing a current scene of the target vehicle based on the basic data to obtain a scene recognition result; determining, according to the scene recognition result, at least one recommended service for the target vehicle; generating a service message of the at least one recommended service; and pushing the service message to the target vehicle.

Abstract: Provided are a compound of Formula (I) and a pharmaceutical composition thereof, as well as a method for using the compounds of Formula (I) to prevent and/or treat immune-related disorders.

Abstract: A point of interest (POI)-based information recommendation method and apparatus, an electronic device, and a computer-readable storage medium are provided. The method includes: determining an encircling region encircling a POI in an electronic map; using an original boundary of the encircling region as an inner boundary and performing expansion processing on the inner boundary, to obtain an outer boundary of the encircling region; determining candidate location relationships between a terminal device and the inner boundary and the outer boundary according to positioning data of the terminal device; determining a real-time state according to a historical state of the terminal device and the candidate location relationships, the real-time state being used for representing a location relationship between the terminal device and the inner boundary; and controlling, according to the real-time state, information about the POI outputted through a location service.

Abstract: Some embodiments of the present disclosure relate to biometric characteristic detection technology, which provide a method and chip for biometric characteristic acquisition, and a computer readable storage medium. The method for biometric characteristic acquisition includes: acquiring a plurality of configuration parameters, where the plurality of configuration parameters include a first exposure duration, parameters defining a first region and a target photosensitive value, where the first region is a local region in a photosensitive region of the chip for biometric characteristic acquisition; exposing the first region according to the first exposure duration, and acquiring a photosensitive value of the first region; determining a second exposure duration required to acquire the target photosensitive value in the photosensitive region according to the photosensitive value of the first region and the first exposure duration; and acquiring a biometric image according to the second exposure duration.

Abstract: A compound represented by formula (I) and a pharmaceutical composition thereof. The compound represented by formula (I) may be used as an adenosine receptor inhibitor, especially as an A2A and/or A2B inhibitor, for example, the compound may be used to prevent or treat diseases related to A2A and/or A2B activity or expression.

Abstract: The field is related to plant breeding and methods of identifying and selecting plants with resistance to southern corn rust. Provided are methods to identify novel genes that encode proteins providing plant resistance to southern corn rust and uses thereof. These disease resistant genes are useful in the production of resistant plants through breeding, transgenic modification, or genome editing.