Abstract: The present application discloses a class of guaianolide sesquiterpene lactone derivatives and pharmaceutical use thereof. The guaianolide sesquiterpene lactone derivative or a pharmaceutically acceptable salt thereof is shown as general formula I. In the present application, a class of novel guaianolide sesquiterpene lactone derivatives are found by structural optimization with abundant natural ingredients such as parthenolide and dehydrocostus lactone as raw materials, which derivatives have good inhibitory activity on the activation of the NLRP3 inflammasome, and the chemical stability, water solubility and oral bioavailability of which are significantly improved, and it is verified by experiments that the derivatives have inhibitory effects on the activity of the NLRP3 inflammasome and have potential pharmaceutical applications.

Abstract: A handle assembly for an infant carrier is provided. The handle assembly allows the handle to be oriented in one of a plurality of positions, such as a stroller position, and infant carrier position and a car seat position. The handle assembly may include a locking mechanism allowing a handle extension to be extended only when the handle rotated to the stroller position. The handle assembly may also include a blocking mechanism that prevents the handle from rotating from the stroller position if the handle is extended.

Abstract: The present application discloses a display panel and a display device. The display panel includes pixel areas and transmitting areas in a first display area. The display panel further includes a light-emitting unit layer including light-emitting units, an auxiliary layer, a first electrode layer covering the light-emitting unit layer and at least part of the auxiliary layer, and a transparent auxiliary electrode layer at least covering part of the auxiliary layer and electrically connected to the first electrode layer. A thickness of the first electrode layer on the auxiliary layer is less than a thickness of the first electrode layer on the light-emitting unit layer.

Abstract: A compound of formula (I) having the activity of inhibiting HPK1 kinase and a pharmaceutical composition comprising the compound. Also provided are the use of the compound in the prevention and/or treatment of cancers, tumors, inflammatory diseases, autoimmune diseases or immune-mediated diseases.

Abstract: Provided are a compound having the structure of formula (I) for inhibiting Wnt pathway activity, a pharmaceutical composition comprising the compound, and use of the compound in prevention and/or treatment of cancers, tumors, inflammatory diseases, autoimmune diseases, or immune-mediated diseases.

Abstract: Some embodiments of the present disclosure relate to biometric characteristic detection technology, which provide a method and chip for biometric characteristic acquisition, and a computer readable storage medium. The method for biometric characteristic acquisition includes: acquiring a plurality of configuration parameters, where the plurality of configuration parameters include a first exposure duration, parameters defining a first region and a target photosensitive value, where the first region is a local region in a photosensitive region of the chip for biometric characteristic acquisition; exposing the first region according to the first exposure duration, and acquiring a photosensitive value of the first region; determining a second exposure duration required to acquire the target photosensitive value in the photosensitive region according to the photosensitive value of the first region and the first exposure duration; and acquiring a biometric image according to the second exposure duration.

Abstract: A message pushing method, a storage medium, and a server are disclosed in this disclosure, belonging to the field of Internet of Vehicles. The method includes: obtaining basic data associated with a target vehicle; recognizing a current scene of the target vehicle based on the basic data to obtain a scene recognition result; determining, according to the scene recognition result, at least one recommended service for the target vehicle; generating a service message of the at least one recommended service; and pushing the service message to the target vehicle.

Abstract: Provided are a compound of Formula (I) and a pharmaceutical composition thereof, as well as a method for using the compounds of Formula (I) to prevent and/or treat immune-related disorders.

Abstract: A point of interest (POI)-based information recommendation method and apparatus, an electronic device, and a computer-readable storage medium are provided. The method includes: determining an encircling region encircling a POI in an electronic map; using an original boundary of the encircling region as an inner boundary and performing expansion processing on the inner boundary, to obtain an outer boundary of the encircling region; determining candidate location relationships between a terminal device and the inner boundary and the outer boundary according to positioning data of the terminal device; determining a real-time state according to a historical state of the terminal device and the candidate location relationships, the real-time state being used for representing a location relationship between the terminal device and the inner boundary; and controlling, according to the real-time state, information about the POI outputted through a location service.

Abstract: Some embodiments of the present disclosure relate to biometric characteristic detection technology, which provide a method and chip for biometric characteristic acquisition, and a computer readable storage medium. The method for biometric characteristic acquisition includes: acquiring a plurality of configuration parameters, where the plurality of configuration parameters include a first exposure duration, parameters defining a first region and a target photosensitive value, where the first region is a local region in a photosensitive region of the chip for biometric characteristic acquisition; exposing the first region according to the first exposure duration, and acquiring a photosensitive value of the first region; determining a second exposure duration required to acquire the target photosensitive value in the photosensitive region according to the photosensitive value of the first region and the first exposure duration; and acquiring a biometric image according to the second exposure duration.

Abstract: A compound represented by formula (I) and a pharmaceutical composition thereof. The compound represented by formula (I) may be used as an adenosine receptor inhibitor, especially as an A2A and/or A2B inhibitor, for example, the compound may be used to prevent or treat diseases related to A2A and/or A2B activity or expression.

Abstract: The field is related to plant breeding and methods of identifying and selecting plants with resistance to southern corn rust. Provided are methods to identify novel genes that encode proteins providing plant resistance to southern corn rust and uses thereof. These disease resistant genes are useful in the production of resistant plants through breeding, transgenic modification, or genome editing.

Abstract: A message pushing method, a storage medium, and a server are disclosed in this disclosure, belonging to the field of Internet of Vehicles. The method includes: obtaining basic data associated with a target vehicle; recognizing a current scene of the target vehicle based on the basic data to obtain a scene recognition result; determining, according to the scene recognition result, at least one recommended service for the target vehicle; generating a service message of the at least one recommended service; and pushing the service message to the target vehicle.

Abstract: Embodiments of this application disclose an image processing method and apparatus, an electronic device, and a storage medium. The method includes obtaining a remaining mileage parameter of a vehicle; obtaining a start position of the vehicle on a map display interface; determining a target travel range on the map display interface according to the start position and the remaining mileage parameter; and displaying the target travel range on the map display interface.

Abstract: The present invention discloses a multi-mode imaging optical system. The multi-mode imaging optical system includes a stage configured to hold a to-be-tested sample. An imaging unit implements in-situ imaging of the to-be-tested sample. An absorption and forward scattering illumination unit irradiates the to-be-tested sample, and forms absorption imaging or forward scattered light imaging in the imaging unit. A side scattering illumination unit performs a first oblique illumination on the to-be-tested sample, so that scattered light of microparticles in the to-be-tested sample forms side scattered light imaging in the imaging unit. A fluorescent illumination unit performs a second oblique illumination on the to-be-tested sample, and excites the microparticles in the to-be-tested sample to emit fluorescence, where the fluorescence forms fluorescence imaging in the imaging unit.

Abstract: A navigation method for a terminal includes determining navigation guiding points on a navigation path; obtaining each directional road name of each navigation guiding point, the directional road name being a road name of a second road segment to which the navigation guiding point leads; and calculating a matching degree between each directional road name and direction information of each third road segment, the third road segment being a first road segment on the navigation path, located after the navigation guiding point, and the direction information of the third road segment comprising a road name of the third road segment and a directional road name of the third road segment. The method also includes determining a weight value of each directional road name according to the matching degree; and when the terminal is at the navigation guiding point, prompting each directional road name according to the weight value.

Abstract: The field is related to plant breeding and methods of identifying and selecting plants with resistance to southern corn rust. Provided are methods to identify novel genes that encode proteins providing plant resistance to southern corn rust and uses thereof. These disease resistant genes are useful in the production of resistant plants through breeding, transgenic modification, or genome editing.

Abstract: A device for detecting a defect of a laser welding cover lens includes a coaxial light source configured to emit collimating detection light, wherein the direction of the detection light is perpendicular to a preset horizontal direction; a half transparent and half reflecting mirror arranged above the coaxial light source to reflect the detection light to a preset position; a reflecting mirror configured to reflect light from the half transparent and half reflecting mirror to the cover lens; an industrial camera parallel to the half transparent and half reflecting mirror and the reflecting mirror and configured to receive incident light from the detection light to obtain a detection image, wherein the incident light is reflected by the cover lens and passes through the reflecting mirror and the half transparent and half reflecting mirror; and a processor configured to determine whether there exists a bad point on the cover lens.

Abstract: The field is related to plant breeding and methods of identifying and selecting plants with resistance to southern corn rust. Provided are methods to identify novel genes that encode proteins providing plant resistance to southern corn rust and uses thereof. These disease resistant genes are useful in the production of resistant plants through breeding, transgenic modification, or genome editing.

Abstract: The present invention discloses a multi-mode imaging optical system. The multi-mode imaging optical system includes a stage configured to hold a to-be-tested sample. An imaging unit, implements in-situ imaging of the to-be-tested sample. An absorption and forward scattering illumination unit, irradiates the to-be-tested sample, and forms absorption imaging or forward scattered light imaging in the imaging unit. A side scattering illumination unit, performs a first oblique illumination on the to-be-tested sample, so that scattered light of microparticles in the to-be-tested sample forms side scattered light imaging in the imaging unit. A fluorescent illumination unit, performs a second oblique illumination on the to-be-tested sample, and excites the microparticles in the to-be-tested sample to emit fluorescence, where the fluorescence forms fluorescence imaging in the imaging unit.