Patents by Inventor Mengchao Shi

Mengchao Shi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MONOCLONAL IGM ANTIBODIES FROM ENTIRELY CARBOHYDRATE CONSTRUCTS
    Publication number: 20240092932
    Abstract: Entirely carbohydrate immunogens, monoclonal antibodies generated from immune responses to entirely carbohydrate immunogens, vaccine compositions, pharmaceutical compositions, and methods of making and using the same, are described.
    Type: Application
    Filed: November 10, 2023
    Publication date: March 21, 2024
    Applicant: The University Of Toledo
    Inventors: Peter Andreana, Kevin Trabbic, Mengchao Shi, Jean Paul Bourgault
  • CDK INHIBITORS AND PHARMACEUTICAL USES THEREOF
    Publication number: 20240050577
    Abstract: The disclosure relates to bifunctional CDK-modulating compounds having the structure W-L-T, where W is a targeting group that binds specifically to a CDK protein, T is an E3-ligase binding group, and L is absent or is a bivalent linking group that connects W and T together via a covalent linkage. Compounds and pharmaceutical compositions thereof can promote degradation of one or more CDK protein in a cell and are thus useful for treating, inhibiting, and preventing CDK-associated diseases, disorders and conditions, including cancers.
    Type: Application
    Filed: April 26, 2023
    Publication date: February 15, 2024
    Inventors: Jiasheng LV, Yao LIU, Xiangyang LI, Xianfeng LIN, Qisheng LIU, Yuanhong GU, Kang DU, Zhihong ZHANG, Mengchao SHI, Yuhua ZHANG, Jian GE, Tianlun ZHOU, Xiangsheng YE, Xianqi KONG, Dawei CHEN
  • INHIBITORS OF RNA-GUIDED NUCLEASE TARGET BINDING AND USES THEREOF
    Publication number: 20210177832
    Abstract: Compositions and methods for inhibiting the activity of RNA-guided endonucleases, and methods for identifying such compositions are included. Methods of treatment using the inhibitory compounds, formulations and methods are also detailed, as well as control of nucleic acid editing systems and methods using said compounds.
    Type: Application
    Filed: August 20, 2019
    Publication date: June 17, 2021
    Inventors: Amit CHOUDHARY, Basudeb MAJI, Soumyashree Ashok GANGOPADHYAY, Miseon LEE, Mengchao SHI
  • MONOCLONAL IGM ANTIBODIES FROM ENTIRELY CARBOHYDRATE CONSTRUCTS
    Publication number: 20190345255
    Abstract: Entirely carbohydrate immunogens, monoclonal antibodies generated from immune responses to entirely carbohydrate immunogens, vaccine compositions, pharmaceutical compositions, and methods of making and using the same, are described.
    Type: Application
    Filed: September 19, 2017
    Publication date: November 14, 2019
    Applicant: The University of Toledo
    Inventors: Peter Andreana, Kevin Trabbic, Mengchao Shi, Jean Paul Bourgault