Patents by Inventor Mengjun Shu

Mengjun Shu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mutated antibody of fully humanized HER2 antibody, and encoding gene and use thereof
    Patent number: 10253108
    Abstract: The present invention provides a mutated antibody of the fully humanized HER2 antibody GB235-019, wherein the amino acid sequence of the heavy chain variable region and the amino acid sequence of the light chain variable region of the mutated antibody are respectively SEQ ID NO: 10, SEQ ID NO: 2; SEQ ID NO: 11, SEQ ID NO: 2; or SEQ ID NO: 12, SEQ ID NO: 2. The mutated antibody has the ability to specifically bind to human HER2 antigen, similar to the GB235-019 antibody. They can also be used in combination with additional HER2 positive tumor therapeutic agents for treating HER2 positive tumor, weakly positive tumor or negative tumor.
    Type: Grant
    Filed: December 8, 2015
    Date of Patent: April 9, 2019
    Assignee: Genor Biopharma Co., Ltd.
    Inventors: Qing Zhou, Mengjun Shu, Zhuzi He, Jun Lin
  • MUTATED ANTIBODY OF FULLY HUMANIZED HER2 ANTIBODY, AND ENCODING GENE AND USE THEREOF
    Publication number: 20170037146
    Abstract: The present invention provides a mutated antibody of the fully humanized HER2 antibody GB235-019, wherein the amino acid sequence of the heavy chain variable region and the amino acid sequence of the light chain variable region of the mutated antibody are respectively SEQ ID NO: 10, SEQ ID NO: 2; SEQ ID NO: 11, SEQ ID NO: 2; or SEQ ID NO:12, SEQ ID NO:2. The mutated antibody has the ability to specifically bind to human HER2 antigen, similar to the GB235-019 antibody. They can also be used in combination with additional HER2 positive tumor therapeutic agents for treating HER2 positive tumor, weakly positive tumor or negative tumor.
    Type: Application
    Filed: December 8, 2015
    Publication date: February 9, 2017
    Applicant: Genor Biopharma Co., Ltd
    Inventors: Qing Zhou, Mengjun Shu, Zhuzi He, Jun Lin