Abstract: Disclosed are anti-fouling and optionally specific binding surfaces, methods for forming anti-fouling and optionally specific binding surfaces, and molecules that may be useful for forming anti-fouling and optionally specific binding surfaces. The surfaces may be formed by employing a molecule comprising a poly(2-oxazoline) having functional groups. In an embodiment, the poly(2-oxazoline) comprises a carboxyl endgroup, an amine endgroup, an N- hydroxysuccinimide endgroup, an oxirane endgroup, an oxetane endgroup, or an isocyanate endgroup, which may enable attachment of a specific binding moiety to the poly(2-oxazoline). In an embodiment, the poly(2-oxazoline) molecule comprises a (meth)acrylate functionality that may allow for attachment to a surface comprising a moiety capable of nucleophilic conjugate addition.

Abstract: Disclosed are anti-fouling and optionally specific binding surfaces, methods for forming anti-fouling and optionally specific binding surfaces, and molecules that may be useful for forming anti-fouling and optionally specific binding surfaces. The surfaces may be formed by employing a molecule comprising a poly(2-oxazoline) having functional groups. In an embodiment, the poly(2-oxazoline) comprises a carboxyl endgroup, an amine endgroup, an N-hydroxysuccinimide endgroup, an oxirane endgroup, an oxetane endgroup, or an isocyanate endgroup, which may enable attachment of a specific binding moiety to the poly(2-oxazoline). In an embodiment, the poly(2-oxazoline) molecule comprises a (meth)acrylate functionality that may allow for attachment to a surface comprising a moiety capable of nucleophilic conjugate addition.

Abstract: Disclosed are anti-fouling and optionally specific binding surfaces, methods for forming anti-fouling and optionally specific binding surfaces, and molecules that may be useful for forming anti-fouling and optionally specific binding surfaces. The surfaces may be formed by employing a molecule comprising a poly(2-oxazoline) having functional groups. In an embodiment, the poly(2-oxazoline) comprises a carboxyl endgroup, an amine endgroup, an N-hydroxysuccinimide endgroup, an oxirane endgroup, an oxetane endgroup, or an isocyanate endgroup, which may enable attachment of a specific binding moiety to the poly(2-oxazoline). In an embodiment, the poly(2-oxazoline) molecule comprises a (meth)acrylate functionality that may allow for attachment to a surface comprising a moiety capable of nucleophilic conjugate addition.

Abstract: The invention is directed to a macromer comprising unit derived from a siloxane diol, di-isocyanates and a diol comprising a pendant group comprising an oligomer or polymer derived from methyl oxazoline or ethyl oxazoline. The invention also relates to a process for the preparation of said macromers, and to that the use of said macromers. The macromers according to the invention may be used in lenses, such as ophthalmic lenses. Films comprising the macromers according to the invention provide a surprisingly low modulus in combination with a high water content and oxidative stability.

Abstract: The invention is directed to a macromer comprising unit derived from a siloxane diol, di-isocyanates and a diol comprising a pendant group comprising an oligomer or polymer derived from methyl oxazoline or ethyl oxazoline. The invention also relates to a process for the preparation of said macromers, and to that the use of said macromers. The macromers according to the invention may be used in lenses, such as ophthalmic lenses. Films comprising the macromers according to the invention provide a surprisingly low modulus in combination with a high water content and oxidative stability.