Patents by Inventor Mengxiao Yu

Mengxiao Yu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITION COMPRISING POLYETHYLENE GLYCOL CONJUGATED TO INDOCYANINE GREEN AND METHODS OF USE
    Publication number: 20230398237
    Abstract: The present disclosure provides polyethylene glycol-indocyanine green conjugates as well as the methods of using such conjugates, such as diagnosis, tissue imaging, temporal monitoring, and treatment.
    Type: Application
    Filed: August 24, 2021
    Publication date: December 14, 2023
    Inventors: Jie ZHENG, Bujie DU, Mengxiao YU
  • RENAL CLEARABLE NANOPARTICLES AS EXOGENOUS MARKERS FOR EVALUATING KIDNEY FUNCTION
    Publication number: 20220146523
    Abstract: A method for evaluating kidney function utilizing a nanoparticle that can be eliminated from the body by the kidneys as an exogenous marker. The method includes administering the nanoparticles to a subject, followed by collecting a blood or urine sample after a period of time, characterizing the nanoparticles in the blood or urine sample, and finally comparing a characteristic parameter of the nanoparticles in the blood or urine sample between the tested subject and a control group having normal kidney function.
    Type: Application
    Filed: February 26, 2020
    Publication date: May 12, 2022
    Inventors: Jie ZHENG, Mengxiao YU, Xuhui NING
  • Methods and systems for noninvasive fluorescence-based functional imaging of kidneys
    Patent number: 10300151
    Abstract: Methods and systems for evaluating renal function of a live subject. The method includes intravenously administering nanoparticles of a noble metal to the kidney of the live subject, followed by illuminating the kidney with a near infrared excitation wavelength such that the nanoparticles in the kidney fluoresce, and finally detecting presence or absence of nanoparticle fluorescence in the kidney. Detecting presence or absence of nanoparticle fluorescence includes obtaining at least one image of the kidney through the subject's skin.
    Type: Grant
    Filed: September 12, 2016
    Date of Patent: May 28, 2019
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Jie Zheng, Mengxiao Yu
  • Nanoparticles for targeting acid tumor microenvironments
    Patent number: 10012653
    Abstract: A composition is disclosed which is capable of being used for detection, comprising a noble metal nanoparticle. The inventive compositions exhibit little interaction with serum proteins while exhibiting pH-dependent adsorption onto live cell membranes. The nanoparticles of the claimed invention are capable of interacting with cell membranes, which in turn permits the advantages of nanoparticle bio-imaging to be extended to many pH dependent biological processes such as targeting acidic tumor microenvironment.
    Type: Grant
    Filed: June 14, 2012
    Date of Patent: July 3, 2018
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Jie Zheng, Mengxiao Yu
  • METHODS AND SYSTEMS FOR NONINVASIVE FLUORESCENCE-BASED FUNCTIONAL IMAGING OF KIDNEYS
    Publication number: 20170072073
    Abstract: Methods and systems for evaluating renal function of a live subject. The method includes intravenously administering nanoparticles of a noble metal to the kidney of the live subject, followed by illuminating the kidney with a near infrared excitation wavelength such that the nanoparticles in the kidney fluoresce, and finally detecting presence or absence of nanoparticle fluorescence in the kidney. Detecting presence or absence of nanoparticle fluorescence includes obtaining at least one image of the kidney through the subject's skin.
    Type: Application
    Filed: September 12, 2016
    Publication date: March 16, 2017
    Inventors: Jie Zheng, Mengxiao Yu