Abstract: A method of investigating a reservoir region in a subsurface formation by a time-lapse seismic survey, which subsurface formation comprises a further formation region adjacent to the reservoir region, which method comprises the steps of obtaining data from a time-lapse seismic survey including seismic data of the subsurface formation at a first point in time and a later point in time, processing the seismic data to obtain a seismic representation of change in a predetermined seismic parameter in the further formation region, which seismic parameter is dependent on stress; interpreting the seismic representation of change in the seismic parameter in the further formation region for an indication of changes of stress distribution in the further formation region; and deriving a property of the reservoir region using the indication of change of stress distribution in the further formation region.