Abstract: The present invention relates to a sensor cartridge (100) comprising: a sample depot (10) which is configured to store a liquid sample; a first cartridge portion (20) comprising a first measurement chamber (22) which is coupled to the sample depot (10) and configured to receive a quantity of the liquid sample from the sample depot (10), wherein the first cartridge portion (20) is configured to measure a first analyte using a first modality on the quantity of the liquid sample and to provide a first analyte test signal; a cartridge portion (30-1) comprising a second measurement chamber (32-1) which is coupled to the first measurement chamber (20), which is configured to receive the quantity of the liquid sample from the first measurement chamber (22), wherein the cartridge portion (30) is configured to measure a second analyte using a second modality on the quantity of the liquid sample and to provide a second analyte test signal.

Abstract: The invention relates to a method and an apparatus for the investigation of a sample material that is stored in the sample chamber (303) of a storage unit (300). A multi-spot generator MSG (100) and a transmission section (200) generate an array of sample light spots (501) within the sample chamber. Input light (504) that leaves the storage unit (300) in forward direction is mapped onto a CCD array (401) and measured as reference. Moreover, fluorescence light (500) that is stimulated in the sample chamber (303) is measured by a second CCD array which is disposed perpendicular to the optical path of the input light (504).

Abstract: The invention relates to a method and an apparatus for the investigation of a sample material by multiple sample light spots (501) generated by evanescent waves. An array of source light spots (510) is generated by a multi-spot generator, e.g. a multi-mode interferometer (106), and mapped onto sample light spots (501) in a sample layer (302) by (micro-)lenses (202, 203) or by the Talbot effect. The input light (504) of the source light spots (510) is shaped such that all of it is totally internally reflected at the interface between a transparent carrier plate (301) and the sample layer (302). Thus the sample light spots (501) consist of evanescent waves only and are restricted to a limited volume. In a preferred application, fluorescence stimulated in the sample light spots (501) is detected with spatial resolution by a CCD array (401).

Abstract: The invention provides a method and a device (10) for distinguishing a specific binding from a less specific binding between at least one magnetic nanoparticle (11) and a surface of another entity by applying a magnetic field and detecting a physical parameter relating to magnetic nanoparticle rotational or motional freedom while the magnetic nanoparticle (11) is attached to the surface. The method and device (10) may be applied to in-vivo and in-vitro biomolecular diagnostics. The sensor (10) according to the present invention combines in one sensor (10) the detection of magnetic particles or labels (11) and determination of the binding quality and the properties of magnetic particles or labels (11) which are bound to the surface of another entity.

Abstract: A method and a device for on-chip magnetic resonance spectroscopy (FMR, SPR, EPR, ESR, NMR) is proposed. On-chip magnetic resonance spectroscopy may be applied to non-magnetic as well as magnetic materials and to solids, liquids and gases. The method of the present invention is suitable for miniaturised materials analysis such as for example microfluidics. The strength of the method lies in the combination of highly efficient spin excitation near on-chip current wires with very sensitive on-chip magnetic sensors. The method and device also allows to separately detect different types of magnetic particles or molecules.

Abstract: Provided is a device, an assembly comprising said device, a sub-assembly and an element suitable for use in the assembly. The device comprises a body of an electrically insulating material having a first side and an opposite second side, the body being provided with conductors according to a desired pattern, said conductors being anchored in the body. The body is provided with a through-hole extending from the first side to the second side of the body and having a surfacial area which is smaller on the first side than on the second side. Such a device can very suitably be used in an assembly comprising an element which is a sensor, preferably a chemical sensor, and particularly a biosensor.

Abstract: A device (3) and method to generate independent fluid samples (51) for multichannel analysis, preferably in diagnostic cartridges, are disclosed according to the invention. A fluidic device (3), preferably a microfluidic device, has a plurality of fluid channels (35). Fluids are transported in the fluid channels. A cross-over channel (32) has a fluid inlet (33) and a fluid outlet (34). In use of said device (3), a method is performed. According to the method, the sample channels are filled with sample fluid up to a threshold (39). A flush fluid (gas or inert liquid) is then flushed through the sample-filled cross-over channel, replacing the sample fluid with flush fluid. Subsequently the cross-over channels' inlet and outlet are closed and the sample fluid is pushed further into the channel arrays (30, 31). Alternatively, an appropriate pressure is applied to the fluid in order to push the fluid into said sample channels.

Abstract: An assay as well as tools and apparatus therefore are disclosed for determining interaction between microbiological entities such as bioactive molecules using at least a first particle or microcarrier e.g. a bead, and a second particle which may also be a microcarrier, e.g. a second bead. At least the first microcarrier is magnetic. When two beads are used and both beads are magnetic, the beads preferably differ in the size of their magnetic moment. A means is provided for placing a binding between bioactive molecules under a mechanical stress to thereby distinguish between bindings of different strengths. In one aspect, the second bead, (with a larger magnetic moment) is used to magnetically remove target molecules linked to beads with smaller magnetic moment which are weakly bound to a capture molecule (itself generally coupled to a mobile or immobile surface). Alternatively, fluid frictional forces can be applied to one of the particles to disrupt weak bindings.

Abstract: A device and method is disclosed for the detection or determination of the presence of magnetic particles (15), such as for example, but not limited to, magnetic tianoparticles. In particular it relates to an integrated or on-chip magnetic sensor element (11) for the detection of magnetic particles. The device and method of the present invention o er high signal-to-noise ratio and low power consumption and do not require an external magnetic field. They may be used for magnetic detection of binding of biological molecules on a micro-array or biochip.

Abstract: The present invention relates to a method and a device for magnetic detection of binding of biological molecules on a biochip. A magnetoresistive sensor device for measuring an areal density of magnetic nanoparticles on a micro-array, the magnetic nanoparticles (15) being directly or indirectly coupled to the target sample (11), is described. The magnetoresistive sensor device comprises a substrate (3) having attached thereto binding sites (9) able to selectively bind target sample (11), and a magnetoresistive sensor for detecting the magnetic field of the nanoparticles (15) coupled to the target sample. The magnetoresistive sensor comprises a plurality of magnetoresistive sensing elements (17, 19), the width and length dimensions of which are at least a factor 10 or more, preferably a factor 100 or more larger than the diameter of the nanoparticles (15). A corresponding method is described as well.

Abstract: A system for manipulating a small object (3) comprising a substrate to receive the small object (3), a liquid droplet (4), which carries the small object (3) on the substrate, and a pre-treated surface structure of the substrate in the vicinity (1,2) of the placement position (1) of the small object (3). The small objects (3) like silicon dies in the range from 100 down to 1 micrometer are fine-placed by an evaporating droplet (4). The dies will serve as active electronic elements in large-area displays and other applications.

Abstract: A device (1) and method for measuring and or detecting the presence of biomolecules. The device comprises a resonance circuit arranged to operate and emit a resonance frequency (f). The resonance circuit comprises or is coupled to a sensor element (5) for detecting the binding of biomolecules (6a) to binding sites (5a). The binding of the biomolecules changes a physical property (R, L, C. mass) of the sensor element (5), which in it's turn, either directly when the sensor element forms part of the resonance circuit, or via a coupling of the sensor element to the resonance circuit, the resonance frequency. The change in the resonance frequency is detected. The device comprises a remote power transmission element, such as a photodiode or coil, for providing power to the resonance circuit using light or RF radiation respectively.

Abstract: In a 2D/3D display, a switchable lenticular array having foci which can be switched in a continuous way between first focal strength and a second focal strength is provided. The switchable lenticular array comprises fluid cylindrical lens portions, while the foci can be controlled by electrowetting.

Abstract: Display device based on layer break up or layer displacement having at least two different states, in which one of the fluids (5) e.g oil in a first state adjoins at least a first support plate (3) and in the second state the other fluid (6) at least partly adjoins the first support plate. In one embodiment a picture element corresponds to a substantially closed space and in the first state the other fluid layer substantially completely adjoins both support plates and is divided in two sub-layers. This makes it possible on the one hand to use lower voltages to make displacement occur. On the other hand this opens the opportunity to color displays.

Abstract: The present invention relates to a method and a device for magnetic detection of binding of biological molecules on a biochip. A magnetoresistive sensor device for measuring an areal density of magnetic nanoparticles on a micro-array, the magnetic nanoparticles (15) being directly or indirectly coupled to the target sample (11), is described. The magnetoresistive sensor device comprises a substrate (3) having attached thereto binding sites (9) able to selectively bind target sample (11), and a magnetoresistive sensor for detecting the magnetic field of the nanoparticles (15) coupled to the target sample. The magnetoresistive sensor comprises a plurality of magnetoresistive sensing elements (17, 19), the width and length dimensions of which are at least a factor 10 or more, preferably a factor 100 or more larger than the diameter of the nanoparticles (15). A corresponding method is described as well.

Abstract: The present invention relates to a magnetoresistive sensing device, a system and a method for determining a density of magnetic particles in a fluid. The magnetoresistive sensing device has a substrate (1) with a layer structure (2) for supporting a fluid (3). The layer structure has a first surface area (4) in a first level and a second surface area (5) in another second level and a magnetoresistive element (6) for detecting the magnetic field of at least one magnetic particle (7) in the fluid, the magnetoresistive element being positioned near a transition (8) between the first and second surface area and facing at least one of the surface areas. A corresponding system and method is described as well.