Patents by Inventor Menno Willem José Prins
Menno Willem José Prins has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240044770Abstract: The present invention relates to a biosensor device for sensing an analyte over a period of time using particle motion, the biosensor device having a surface and a particle, wherein the particle and/or the surface are functionalized, and wherein the biosensor device has a first state in which the particle is associated with the surface and a second state in which the particle is not associated with the surface, and wherein switching between the first and second states depends on the presence, absence and/or concentration of the analyte, whereby motion characteristics of the particle change depending on the presence, absence and/or concentration of the analyte, thereby allowing sensing of the analyte by measuring changes in a spatial coordinate parameter of the particle relative to the surface, and wherein the properties of the particle and surface are selected such that in the second state the particle is within the vicinity of the surface such that the biosensor is able to measure changes in a spatial coordiType: ApplicationFiled: August 17, 2021Publication date: February 8, 2024Inventors: Arthur Martin JONG, Khulan SERGELEN, Menno Willem Jose PRINS, Yu-Ting LIN
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Patent number: 11703503Abstract: Provided herein is a method for biosensing a target substance [110] using a collection of particles [104] tethered to a surface [100] by tether molecules [102] and a plurality of capture molecules. A concentration of the target substance is determined from the time sequence of individual association/dissociation rates of the capture molecules. Competitive assay configurations are also described.Type: GrantFiled: January 2, 2018Date of Patent: July 18, 2023Assignee: Technische Universiteit EindhovenInventors: Emilius Willem Adriaan Visser, Leonardus Josephus van Ijzendoorn, Menno Willem José Prins
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Patent number: 11471077Abstract: A biosensing device for continuous monitoring of an analyte in a fluid matrix includes an electromagnetic excitation element [402], a biosensing surface [406], an opposing surface [410], a separation component [420,422], light collection optics [412], a light sensor [414], an image recording and analysis system [416], and an excitation control system [400]. The separation component is connected to the biosensing surface and to the opposing surface, forming a concave gap region [408] between the biosensing surface and the opposing surface. The biosensing surface comprises biosensing particles sensitive to electromagnetic signals from the electromagnetic excitation element, where an optical response of the biosensing particles to the electromagnetic signals is adapted to change in the presence of an analyte in the gap region. The light collection optics couple light emitted from the biosensing particles on the biosensing surface to the light sensor.Type: GrantFiled: May 2, 2018Date of Patent: October 18, 2022Assignee: Technische Universiteit EindhovenInventors: Menno Willem José Prins, Stefano Cappelli
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Patent number: 11359231Abstract: A method for sensing an analyte uses tethered particle motion. A functionalized particle has a first state in which the functionalized particle is bound to the surface and a second state in which the functionalized particle is not bound to the surface, where the functionalized particle switches between the first and second states depending on the presence and absence of the analyte, thereby changing motion characteristics of the functionalized particle depending on the presence of the analyte. A spatial coordinate parameter of the functionalized particle is measured by a detector, and a processor determines the presence/concentration of the analyte from changes in the measured spatial coordinate parameter.Type: GrantFiled: December 21, 2019Date of Patent: June 14, 2022Assignee: Technische Universiteit EindhovenInventors: Menno Willem José Prins, Maarten Merkx, Leonardus Josephus van Ijzendoorn, Peter Zijlstra, Emilius Willem Adriaan Visser, Max Rose-Marie Wilhelmus Scheepers
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Publication number: 20210341554Abstract: The present invention relates to methods and (bio)sensor systems. Herein, magnetic fields are applied in order to transport magnetic particles laterally over a sensor surface with analyte specific probes. The methods of the invention allow the specific binding of magnetic particles to the sensor surface, while aspecific and unbound particles are removed.Type: ApplicationFiled: July 16, 2021Publication date: November 4, 2021Applicant: SIEMENS HEALTHINEERS NEDERLAND B.V.Inventors: Thea Van Der Wijk, Menno Willem Jose Prins, Richard Joseph Marinus Schroeders
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Publication number: 20210290110Abstract: A biosensing device for continuous monitoring of an analyte in a fluid matrix includes an electromagnetic excitation element [402], a biosensing surface [406], an opposing surface [410], a separation component [420,422], light collection optics [412], a light sensor [414], an image recording and analysis system [416], and an excitation control system [400]. The separation component is connected to the biosensing surface and to the opposing surface, forming a concave gap region [408] between the biosensing surface and the opposing surface. The biosensing surface comprises biosensing particles sensitive to electromagnetic signals from the electro-magnetic excitation element, where an optical response of the biosensing particles to the electromagnetic signals is adapted to change in the presence of an analyte in the gap region. The light collection optics couple light emitted from the biosensing particles on the biosensing surface to the light sensor.Type: ApplicationFiled: May 2, 2018Publication date: September 23, 2021Inventors: Menno Willem José Prins, Stefano Cappelli
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Patent number: 10980624Abstract: A toothbrush (10) includes a brushhead (18), a first force sensor (30A) for measuring a first force exerted by the brushhead at a first angle relative to a tooth and a second force sensor (30B) for measuring a second force exerted by the brushhead at a second angle relative to the tooth, the second angle being different than the first angle, and a processing unit (26). The processing unit is structured to: (i) receive first information indicative of the first force as measured by the first force sensor, (ii) receive second information indicative of the second force as measured by the second force sensor, and (iii) determine information regarding a current brushing angle of the brushhead based on the first information and the second information.Type: GrantFiled: September 19, 2018Date of Patent: April 20, 2021Assignee: KONINKLIJKE PHILIPS N.V.Inventors: Mark Thomas Johnson, Johannes Hendrikus Maria Spruit, Okke Ouweltjes, Edgar Martinus Van Gool, Menno Willem Jose Prins
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Patent number: 10895571Abstract: Methods for preventing aggregation of detection particles in a test for detecting a multi-epitope target analyte comprising two or more similar or identical epitopes in a sample and/or for determining the concentration of the multi-epitope target analyte in a sample by applying a first capture entity which can specifically bind to at least one epitope on the multi-epitope analyte and block the at least one epitope from binding to a detection particle. The detection of the multi-epitope target analyte may further include the use of a second capture entity, which can specifically bind to the same or a similar epitope of the multi-epitope target analyte as the first capture entity. The multi-epitope target may be detected through the use of a system comprising a sensor surface and the use of a first capture entity to block the at least one epitope from binding to a detection particle.Type: GrantFiled: June 5, 2014Date of Patent: January 19, 2021Assignee: SIEMENS HEALTHINEERS NEDERLAND B.V.Inventors: Toon Hendrik Evers, Menno Willem Jose Prins, Jeroen Hans Nieuwenhuis
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Publication number: 20200140932Abstract: A method for sensing an analyte uses tethered particle motion. A functionalized particle has a first state in which the functionalized particle is bound to the surface and a second state in which the functionalized particle is not bound to the surface, where the functionalized particle switches between the first and second states depending on the presence and absence of the analyte, thereby changing motion characteristics of the functionalized particle depending on the presence of the analyte. A spatial coordinate parameter of the functionalized particle is measured by a detector, and a processor determines the presence/concentration of the analyte from changes in the measured spatial coordinate parameter.Type: ApplicationFiled: December 21, 2019Publication date: May 7, 2020Inventors: Menno Willem José Prins, Maarten Merkx, Leonardus Josephus van Ijzendoorn, Peter Zijlstra, Emilius Willem Adriaan Visser, Max Rose-Marie Wilhelmus Scheepers
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Patent number: 10620195Abstract: An analyte in a matrix is sensed using a sensing device having a detection probe conjugated to a mediator-receptor that is not a binder for the analyte. The sensor device is provided with mediators conjugated to analyte-receptors, where the mediators are selected to bind to the mediator-receptors, and where the analyte-receptors are selected to bind to the analyte. In some embodiments, the mediators are bound to the detection probe by a tether molecule, or tether molecule fragment, or tether domain. In other embodiments, the mediators are not bound to the detection probe. The presence of the analyte is detected by optically or electrically detecting changes of distance between the mediators and the mediator-receptor, indicative of association and/or dissociation events between mediators and mediator-receptor, the characteristics of which are affected by whether the analyte is bound to the analyte-receptor.Type: GrantFiled: November 12, 2015Date of Patent: April 14, 2020Assignee: Technische Universiteit EindhovenInventors: Menno Willem José Prins, Peter Zijlstra, Lucas Brunsveld
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Publication number: 20200025751Abstract: A method for biosensing a target substance [110] uses a collection of particles [?] tethered to a surface [100] by tether molecules [102]. First capture molecules [106] are attached to the particles [104] or to the tether molecules. Second capture molecules [108] are attached to the surface [100] or to the tether molecules. The first capture molecules [106] are selected to bind to the target substance [110] and have a first target dissociation rate, and the second capture molecules [108] are selected to bind to the target substance [110] and have a second target dissociation rate that differs from the first target dissociation rate by at least a factor of three. A time series of a spatial coordinate parameter of the particles is detected, and identifying a time sequence of individual association/dissociation events of the target substance with the capture molecules are identified within the detected time series.Type: ApplicationFiled: January 2, 2018Publication date: January 23, 2020Inventors: Emilius Willem Adriaan Visser, Leonardus Josephus van Ijzendoorn, Menno Willem José Prins
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Patent number: 10525465Abstract: A cartridge includes an inlet portion that is connected to an assay chamber and a suction reservoir. The inlet portion is configured to allow a direct uptake of sample medium. During this uptake, air is trapped in the assay chamber, which prevents a premature entrance of the sample medium into the assay chamber. The transfer of the sample medium from the inlet portion to the assay chamber is thus controllably initiated at a later time, for example by opening a vent port connected to the assay chamber.Type: GrantFiled: November 26, 2013Date of Patent: January 7, 2020Assignee: KONINKLIJKE PHILIPS N.V.Inventors: Menno Willem Jose Prins, Godefridus Johannes Verhoeckx
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Patent number: 10519486Abstract: A method for sensing an analyte uses tethered particle motion. A functionalized particle [500] has a first state [504] in which the functionalized particle is bound to the surface and a second state [502] in which the functionalized particle is not bound to the surface, where the functionalized particle switches between the first and second states depending on the presence and absence of the analyte, thereby changing motion characteristics of the functionalized particle depending on the presence of the analyte. A spatial coordinate parameter of the functionalized particle is measured by a detector [516], and a processor [518] determines the presence/concentration of the analyte from changes in the measured spatial coordinate parameter.Type: GrantFiled: December 15, 2015Date of Patent: December 31, 2019Assignee: Technische Universiteit EindhovenInventors: Menno Willem José Prins, Maarten Merkx, Leonardus Josephus van Ijzendoorn, Peter Zijlstra, Emilius Willem Adriaan Visser, Max Rose-Marie Wilhelmus Scheepers
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Patent number: 10393634Abstract: A cartridge and an associated apparatus for preparing a biological sample includes a reaction chamber configured to be closed by a substrate carrying the biological sample, where the reaction chamber is connected to a fluidic inlet system and a fluidic outlet system. When the substrate closes the reaction chamber, the fluidic inlet system, the reaction chamber, and the fluidic outlet system constitute a fluidic system that is closed to an environment outside the cartridge with respect to an exchange of liquids. Further, a pressure-driven flow through the reaction chamber may be induced by actuation of deformable membranes formed in the cartridge.Type: GrantFiled: September 24, 2013Date of Patent: August 27, 2019Assignee: KONINKLIJKE PHILIPS N.V.Inventors: Reinhold Wimberger-Friedl, Freek Van Hemert, Anja Van De Stolpe, Menno Willem Jose Prins, Johannes Adrianus Van Tooren
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Patent number: 10330676Abstract: A target analyte in a matrix is sensed using a sensor device having protrusions [500] such as e.g. nanorods, containing free charge carriers. Conformational molecules [504, 506] are bound at a first end to the protrusions, and bound at a second end to a label [502] e.g. a nanoparticle, that is free to move relative to the protrusions. The conformational molecule changes its conformation when bound to the analyte, thereby changing the distance and/or the relative orientation of the label to the protrusion. Energy [510] is used to excite free electrons in the protrusion near a plasmon resonance and resulting optical radiation [514] at wavelengths near the plasmon resonance wavelength is detected [516] and analyzed [518] to determined the presence/concentration of the analyte.Type: GrantFiled: November 12, 2015Date of Patent: June 25, 2019Assignee: Technische Universiteit EindhovenInventors: Peter Zijlstra, Menno Willem José Prins
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Publication number: 20190015182Abstract: A toothbrush (10) includes a brushhead (18), a first force sensor (30A) for measuring a first force exerted by the brushhead at a first angle relative to a tooth and a second force sensor (30B) for measuring a second force exerted by the brushhead at a second angle relative to the tooth, the second angle being different than the first angle, and a processing unit (26). The processing unit is structured to: (i) receive first information indicative of the first force as measured by the first force sensor, (ii) receive second information indicative of the second force as measured by the second force sensor, and (iii) determine information regarding a current brushing angle of the brushhead based on the first information and the second information.Type: ApplicationFiled: September 19, 2018Publication date: January 17, 2019Inventors: MARK THOMAS JOHNSON, JOHANNES HENDRIKUS MARIA SPRUIT, OKKE OUWELTJES, EDGAR MARTINUS VAN GOOL, MENNO WILLEM JOSE PRINS
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Patent number: 10105202Abstract: A toothbrush (10) includes a brushhead (18), a first force sensor (30A) for measuring a first force exerted by the brushhead at a first angle relative to a tooth and a second force sensor (30B) for measuring a second force exerted by the brushhead at a second angle relative to the tooth, the second angle being different than the first angle, and a processing unit (26). The processing unit is structured to: (i) receive first information indicative of the first force as measured by the first force sensor, (ii) receive second information indicative of the second force as measured by the second force sensor, and (iii) determine information regarding a current brushing angle of the brushhead based on the first information and the second information.Type: GrantFiled: October 5, 2015Date of Patent: October 23, 2018Assignee: KONINKLIJKE PHILIPS N.V.Inventors: Mark Thomas Johnson, Johannes Hendrikus Maria Spruit, Okke Ouweltjes, Edgar Martinus Van Gool, Menno Willem Jose Prins
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Patent number: 10092903Abstract: The present invention discloses microfluidic devices with a valve-like structure (3), through which magnetic particles can be transported with minimal transport of fluids. This allows sequential processing of the magnetic particles.Type: GrantFiled: December 16, 2008Date of Patent: October 9, 2018Assignee: KONINKLIJKE PHILIPS N.V.Inventors: Menno Willem Jose Prins, Joost Hubert Maas, Albert Hendrik Jan Immink, Dirkjan Bernhard Van Dam, Maatje Koets, Michel J. M. Bruyninckx, Thea Van Der Wijk, Marius Iosif Boamfa, Remco Den Dulk
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Patent number: 10036729Abstract: The invention relates to a method and a sensor device (100) for the detection of clusters (C) of magnetic particles (MP) in a sample volume (111), particularly of clusters (C) consisting of two magnetic particles (MP) with different binding sites that are bound to a target molecule in a sandwich configuration. Output light (L2) originating from an interaction of input light (L1) with clusters (C) of magnetic particles (MP) is detected. Moreover, the magnetic particles (MP, C) are actuated by a magnetic actuation field (B), wherein said actuation is at least once interrupted by a pause. In this way a high output signal can be achieved that properly reflects the amount of specifically bound clusters (C).Type: GrantFiled: June 18, 2012Date of Patent: July 31, 2018Assignee: KONINKLIJKE PHILIPS N.V.Inventors: Andrea Ranzoni, Menno Willem Jose Prins
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Patent number: 9962693Abstract: An embodiment of the invention relates to a fluidic system (200) in which a first channel (210) and a second channel (230) are separated by a fluidic stop (220), for example a region with a hydrophobic coating and/or a structure (220) with non-capillary internal dimensions. Moreover, it comprises a flexible element (240) that is deformable to enable a flow of a medium across the fluidic stop.Type: GrantFiled: November 18, 2013Date of Patent: May 8, 2018Assignee: KONINKLIJKE PHILIPS N.V.Inventors: Godefridus Johannes Verhoeckx, Nicole Henrica Maria Smulders, Toon Hendrik Evers, Monica Scholten, Menno Willem Jose Prins