Abstract: The invention relates to liposome preparations with controllable vesicle size and type between about 20 and 150 nm and high stability without increased permeability, the vesicle membrane of the liposomes consisting essentially of lecithin and 10%-90%, preferably 16-90%, and most especially 20-80%, of a specified fatty acid-esterified collagen hydrolysate (FAECH), namely, a fatty acid ester of a lipoaminoacid or lipopeptide, representatively OHAP, plus traditional jellifying agents, adjuvants, and pharmaceutical agents as desired, and the production and use thereof in cosmetic and pharmaceutical compositions, as well as a method of controlling vesicle dimensions and reducing vesicle particle size by employing increased and previously believed inoperative ratios of FAECH to lecithin.