Patents by Inventor Mercedes Rincon

Mercedes Rincon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Administering methylation-controlled J protein (MCJ) SIRNA to a kidney cell
    Patent number: 11752193
    Abstract: The invention relates, in part, to methods and compositions that are useful to modulate metabolic function of cells in vivo or in vitro. In some aspects the invention includes methods and/or compositions that increase metabolism in cells, tissues, organs, and/or subjects. In certain aspects the invention includes methods and/or compositions useful to decrease metabolism in cells, tissues, organs, and/or in subjects.
    Type: Grant
    Filed: October 2, 2020
    Date of Patent: September 12, 2023
    Assignee: University of Vermont and State Agricultural College
    Inventors: Mercedes Rincon, Ketki M. Hatle
  • COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSING OF METHYLATION-CONTROLLED J-PROTEIN (MCJ)
    Publication number: 20230092615
    Abstract: Compositions and methods useful to reduce expression of methylation-controlled J-protein (MCJ) gene and for treatment of MCJ-associated diseases and conditions are provided. Provided are MCJ dsRNA agents, MCJ antisense polynucleotide agents, compositions comprising MCJ dsRNA agents, and, compositions comprising MCJ antisense polynucleotide agents that can be used to reduce MCJ expression in cells and subjects.
    Type: Application
    Filed: February 20, 2021
    Publication date: March 23, 2023
    Inventors: Pengcheng Patrick Shao, Mercedes Rincon
  • METHODS AND COMPOSITIONS FOR METABOLIC REGULATION
    Publication number: 20210023172
    Abstract: The invention relates, in part, to methods and compositions that are useful to modulate metabolic function of cells in vivo or in vitro. In some aspects the invention includes methods and/or compositions that increase metabolism in cells, tissues, organs, and/or subjects. In certain aspects the invention includes methods and/or compositions useful to decrease metabolism in cells, tissues, organs, and/or in subjects.
    Type: Application
    Filed: October 2, 2020
    Publication date: January 28, 2021
    Applicant: University of Vermont and State Agricultural College
    Inventors: Mercedes Rincon, Ketki M. Hatle
  • Treatment with methylation-controlled J protein (MCJ)
    Patent number: 10792330
    Abstract: The invention relates, in part, to methods and compositions that are useful to modulate metabolic function of cells in vivo or in vitro. In some aspects the invention includes methods and/or compositions that increase metabolism in cells, tissues, organs, and/or subjects. In certain aspects the invention includes methods and/or compositions useful to decrease metabolism in cells, tissues, organs, and/or in subjects.
    Type: Grant
    Filed: November 7, 2017
    Date of Patent: October 6, 2020
    Assignee: University of Vermont and State Agricultural College
    Inventors: Mercedes Rincon, Ketki M. Hatle
  • METHODS AND COMPOSITIONS TO TREAT DRUG-INDUCED DISEASES AND CONDITIONS
    Publication number: 20200283770
    Abstract: Methods and compounds useful to treat drug-induced diseases and conditions are provided. Methods of administering one or more MCJ-inhibiting compounds to decrease MCJ polypeptide activity in cells, tissues, and/or subjects as a treatment for a drug-induced disease or condition are provided.
    Type: Application
    Filed: May 18, 2020
    Publication date: September 10, 2020
    Applicants: University of Vermont and State Agricultural College, Asociacion Centro de Investigacion Cooperativa en Biociencias-CIC bioGUNE
    Inventors: Mercedes Rincon, Maria Luz Martinez Chantar, Juan Anguita, Oliver Dienz
  • Methods and compositions to treat drug-induced diseases and conditions
    Patent number: 10655126
    Abstract: Methods and compounds useful to treat drug-induced diseases and conditions are provided. Methods of administering one or more MCJ-inhibiting compounds to decrease MCJ polypeptide activity in cells, tissues, and/or subjects as a treatment for a drug-induced disease or condition are provided.
    Type: Grant
    Filed: July 9, 2016
    Date of Patent: May 19, 2020
    Assignees: University of Vermont and State Agricultural College, Asociacion Centro de Investigacion Cooperativa en Biociencias-CIC bioGune
    Inventors: Mercedes Rincon, Maria Luz Martinez Chantar, Juan Anguita, Oliver Dienz
  • Methylation-controlled J protein (MCJ) for treatment of liver disease and altering mitochondrial metabolism
    Patent number: 10583169
    Abstract: The invention relates, in part, to methods and compositions that are useful to modulate metabolic function of cells in vivo or in vitro. In some aspects the invention includes methods and/or compositions that increase metabolism in cells, tissues, organs, and/or subjects. In certain aspects the invention includes methods and/or compositions useful to decrease metabolism in cells, tissues, organs, and/or in subjects.
    Type: Grant
    Filed: July 10, 2013
    Date of Patent: March 10, 2020
    Assignee: University of Vermont and State Agricultural College
    Inventors: Mercedes Rincon, Ketki M. Hatle
  • MCJ agonists and uses therefor
    Patent number: 10350262
    Abstract: The invention relates, in part, to compounds, compositions, and methods useful to treat cancer in cells and subjects. In some aspects the invention includes contacting a cancer cell with one or more exogenous methylation-controlled J protein (MCJ) agonist compounds to increase sensitivity of the cancer cell to one or more chemotherapeutic agents. In certain aspects the invention includes compounds and methods useful to kill cancer cells.
    Type: Grant
    Filed: February 18, 2016
    Date of Patent: July 16, 2019
    Assignee: University of Vermont and State Agricultural College
    Inventors: Mercedes Rincon, Thomas Roberts, Tina Thornton
  • METHODS AND COMPOSITIONS TO TREAT DRUG-INDUCED DISEASES AND CONDITIONS
    Publication number: 20190078086
    Abstract: Methods and compounds useful to treat drug-induced diseases and conditions are provided. Methods of administering one or more MCJ-inhibiting compounds to decrease MCJ polypeptide activity in cells, tissues, and/or subjects as a treatment for a drug-induced disease or condition are provided.
    Type: Application
    Filed: July 9, 2016
    Publication date: March 14, 2019
    Applicants: University of Vermont and State Agricultural College, Asociacion Centro de Investigacion Cooperativa en Biociencias-CIC bioGUNE
    Inventors: Mercedes Rincon, Maria Luz Martinez Chantar, Juan Anguita, Oliver Dienz
  • Methods and products relating to GSK3? regulation
    Patent number: 10052365
    Abstract: The invention relates to methods and compositions for regulation of GSK3? activity. The invention provides phosphorylated GSK3? polypeptides and antibodies that recognize such polypeptides. The invention further includes methods for treating disorders that are associated with elevated or reduced GSK3? activity.
    Type: Grant
    Filed: December 5, 2014
    Date of Patent: August 21, 2018
    Assignee: University of Vermont and State Agricultural College
    Inventors: Mercedes Rincon, Tina M. Thornton
  • METHODS AND COMPOSITONS FOR METABOLIC REGULATION
    Publication number: 20180125930
    Abstract: The invention relates, in part, to methods and compositions that are useful to modulate metabolic function of cells in vivo or in vitro. In some aspects the invention includes methods and/or compositions that increase metabolism in cells, tissues, organs, and/or subjects. In certain aspects the invention includes methods and/or compositions useful to decrease metabolism in cells, tissues, organs, and/or in subjects.
    Type: Application
    Filed: November 7, 2017
    Publication date: May 10, 2018
    Applicant: University of Vermont and State Agricultural College
    Inventors: Mercedes Rincon, Ketki M. Hatle
  • MCJ AGONISTS AND USES THEREFOR
    Publication number: 20180028599
    Abstract: The invention relates, in part, to compounds, compositions, and methods useful to treat cancer in cells and subjects. In some aspects the invention includes compounds and methods that increase chemo-sensitivity and/or reduce chemo-resistance in a cancer cell. In certain aspects the invention includes compounds and methods useful to kill cancer cells.
    Type: Application
    Filed: February 18, 2016
    Publication date: February 1, 2018
    Applicant: University of Vermont and State Agricultural College
    Inventors: Mercedes Rincon, Thomas Roberts, Tina Thornton
  • METHODS AND PRODUCTS RELATING TO GSK3ß REGULATION
    Publication number: 20170151312
    Abstract: The invention relates to methods and compositions for regulation of GSK3? activity. The invention provides phosphorylated GSK3? polypeptides and antibodies that recognize such polypeptides The invention further includes methods for treating disorders that are associated with elevated or reduced GSK3? activity.
    Type: Application
    Filed: December 5, 2014
    Publication date: June 1, 2017
    Applicant: University of Vermont and State Agricultural College
    Inventors: Mercedes Rincon, Tina M. Thornton
  • METHODS AND COMPOSITIONS FOR METABOLIC REGULATION
    Publication number: 20150202257
    Abstract: The invention relates, in part, to methods and compositions that are useful to modulate metabolic function of cells in vivo or in vitro. In some aspects the invention includes methods and/or compositions that increase metabolism in cells, tissues, organs, and/or subjects. In certain aspects the invention includes methods and/or compositions useful to decrease metabolism in cells, tissues, organs, and/or in subjects.
    Type: Application
    Filed: July 10, 2013
    Publication date: July 23, 2015
    Applicant: University of Vermont and State Agricultural College
    Inventors: Mercedes Rincon, Ketki M. Hatle
  • METHODS AND PRODUCTS RELATING TO GSK3ß REGULATION
    Publication number: 20150150950
    Abstract: The invention relates to methods and compositions for regulation of GSK3? activity. The invention provides phosphorylated GSK3? polypeptides and antibodies that recognize such polypeptides The invention further includes methods for treating disorders that are associated with elevated or reduced GSK3? activity.
    Type: Application
    Filed: December 5, 2014
    Publication date: June 4, 2015
    Applicant: University of Vermont and State Agricultural College
    Inventors: Mercedes Rincon, Tina M. Thornton
  • p38 MAPK Pathway Inhibitors as Female-Specific Therapeutics
    Publication number: 20140127231
    Abstract: The present invention provides compositions and methods for preventing and treating a disorder, including, for example, an autoimmune disorder (e.g. multiple sclerosis), neuroinflammation, a neurodegenerative disease, or a behavioral disorder. In one embodiment, the present invention includes administering a p38 MAPK inhibitor to a female subject in order to treat or prevent an autoimmune disorder. In another embodiment, the invention provides administering a p38 MAPK inhibitor to a specific cell population.
    Type: Application
    Filed: November 1, 2013
    Publication date: May 8, 2014
    Applicant: UNIVERSITY OF VERMONT
    Inventors: Cory Teuscher, Mercedes Rincon, Dimitry Krementsov, Rajkumar Noubade
  • METHODS AND PRODUCTS RELATING TO GSK3SS REGULATION
    Publication number: 20130224212
    Abstract: The invention relates to methods and compositions for regulation of GSK3? activity. The invention provides phosphorylated GSK3? polypeptides and antibodies that recognize such polypeptides. The invention further includes methods for treating disorders that are associated with elevated or reduced GSK3? activity.
    Type: Application
    Filed: May 6, 2013
    Publication date: August 29, 2013
    Applicant: University of Vermont and State Agricultural College
    Inventors: Mercedes Rincon, Tina M. Thornton
  • Methods and products relating to GSK3? regulation
    Patent number: 8445648
    Abstract: The invention relates to methods and compositions for regulation of GSK3? activity. The invention provides phosphorylated GSK3? polypeptides and antibodies that recognize such polypeptides. The invention further includes methods for treating disorders that are associated with elevated or reduced GSK3? activity.
    Type: Grant
    Filed: April 29, 2009
    Date of Patent: May 21, 2013
    Assignee: University of Vermont and State Agricultural College
    Inventors: Mercedes Rincon, Tina M. Thornton
  • Anti-methylation-controlled j protein antibodies and uses thereof
    Patent number: 8354237
    Abstract: This application includes, in part, methods of preparing antibodies that specifically bind to methylation-controlling J (MCJ) polypeptide. In some aspects, the application also includes, hybridoma cell lines that produce antibodies that specifically MCJ polypeptide; antibodies and antigen-binding fragments thereof produced with the methods of the application, and methods of using antibodies and antigen-binding fragments that specifically bind MCJ polypeptide for diagnosis and treatment of cancer.
    Type: Grant
    Filed: February 1, 2008
    Date of Patent: January 15, 2013
    Assignee: University of Vermont and State Agriculture College
    Inventors: Mercedes Rincon, Wendy Neveu
  • METHODS AND PRODUCTS RELATING TO GSK3BETA REGULATION
    Publication number: 20110150887
    Abstract: The invention relates to methods and compositions for regulation of GSK3? activity. The invention provides phosphorylated GSK3? polypeptides and antibodies that recognize such polypeptides. The invention further includes methods for treating disorders that are associated with elevated or reduced GSK3? activity.
    Type: Application
    Filed: April 29, 2009
    Publication date: June 23, 2011
    Applicant: University of Vermont and State Agricultural College
    Inventors: Mercedes Rincon, Tina M. Thornton