Abstract: A drive train for a wind-up injection device is described. The drive train includes a torsional energy storage adapted to be loaded or unloaded by a rotatable element, a rotatable user handle, a rotationally driveable expelling mechanism adapted to expel the liquid drug, and a clutch element coupled with the torsional energy storage via the rotatable element and including a ratchet for maintaining the rotatable element at one of a number of discrete angular positions against the torque of the torsional energy storage. The clutch element is adapted to transmit the torque from the user handle to the torsional energy storage, or alternatively from the torsional energy storage to the expelling mechanism. The ratchet is switchable from one position to an adjacent position by a torque transmitted from the user handle to the torsional energy storage. The drive train is adapted to dampen torque peaks visco-elastically and/or visco-frictionally.

Abstract: Computing platforms, methods, and storage media for providing multi-channel authentication are disclosed. Exemplary implementations may: receive, from a plurality of system access channels, authentication data related to a plurality of data transfers and to a plurality of users; consolidate the authentication data from the plurality of access channels to generate a set of consolidated authentication data; and generate a user interface, based on the set of consolidated authentication data, to enable execution of a centrally-provided authentication function at a selected system access channel for a selected user initiating a data transfer. An authentication hub according to an implementation may provide a common authentication experience and improved authentication for the plurality of access channels, which may include a telephone contact center, an in-person or branch location, and online services such as web-based or app-based.

Abstract: A button for a drug delivery device with a reduced operating loudness includes a plate-like button body forming a touch surface, wherein the plate-like button body is coupled by an axial supporting member to a noise-generating interface of the drug delivery device and movable into a longitudinal direction of the drug delivery device, wherein the plate-like button body includes a material composite with at least one first component consisting of a first material and at least one second component consisting of a second material different from the first material, wherein the at least one first component and the at least one second component are coupled via at least one coupling plane that is at least sectionwise slanted or perpendicular to the longitudinal direction. Further, the disclosure describes a button assembly for a drug delivery device which is shock resistant.

Abstract: A drive train for a wind-up injection device is described. The drive train includes a torsional energy storage adapted to be loaded or unloaded by a rotatable element, a rotatable user handle, a rotationally driveable expelling mechanism adapted to expel the liquid drug, and a clutch element coupled with the torsional energy storage via the rotatable element and including a ratchet for maintaining the rotatable element at one of a number of discrete angular positions against the torque of the torsional energy storage. The clutch element is adapted to transmit the torque from the user handle to the torsional energy storage, or alternatively from the torsional energy storage to the expelling mechanism. The ratchet is switchable from one position to an adjacent position by a torque transmitted from the user handle to the torsional energy storage. The drive train is adapted to dampen torque peaks visco-elastically and/or visco-frictionally.

Abstract: A set including a pump dispenser for discharging pharmaceutical or cosmetic liquids and an external evaluation unit, which is designed to be exchangeable so that, after the pump dispenser has been emptied, the evaluation unit can be attached to a new pump dispenser. The evaluation unit can be attached to the discharging head of the pump dispenser such that the evaluation unit detects an actuation button and can be partially displaced with same. The evaluation unit can alternatively have a receiving container which is open on at least one side and into which the pump dispenser can be inserted and the force application of which is detected on actuation.

Abstract: An electronic module connectable to an autoinjector, the electronic module configured to detect and to monitor a dose administering process with the autoinjector or parameters related thereto and to provide a user of the autoinjector with feedback on the dose administering process or parameters related thereto.

Abstract: A set including a pump dispenser for discharging pharmaceutical or cosmetic liquids and an external evaluation unit, which is designed to be exchangeable so that, after the pump dispenser has been emptied, the evaluation unit can be attached to a new pump dispenser. The evaluation unit can be attached to the discharging head of the pump dispenser such that the evaluation unit detects an actuation button and can be partially displaced with same. The evaluation unit can alternatively have a receiving container which is open on at least one side and into which the pump dispenser can be inserted and the force application of which is detected on actuation.

Abstract: The disclosure relates to an injection device for expelling of a number of preset or user-selectable doses of a medicament. The injection device includes an elongated housing extending along an axial direction and configured to accommodate a cartridge containing the medicament and having a bung sealing a proximal end of the cartridge, a windup expelling mechanism, and a dose setting mechanism. The dose setting mechanism includes a handle , a dose tracking member, and a limiter. The dose tracking member is rotatable relative to the housing within a range of positional states and operatively connectable to the handle for tracking a rotation thereof. The limiter is operationally engageable with the dose tracking member and a trigger of the windup expelling mechanism for blocking actuation of the trigger when the dose tracking member is in one of a number of predetermined sections of the range of positional states.

Abstract: The present disclosure relates to a ratchet mechanism and to an injection device for expelling of a number of preset or user-selectable doses of a medicament. The ratchet mechanism comprises a housing and a ratchet member that is circularly shaped and rotationally supported relative to the housing. The ratchet member comprises a ratchet surface, a plurality of ratchet features on the ratchet surface, and one or more intermediate ratchet sections on the ratchet surface extending between the plurality of ratchet features. The ratchet mechanism further comprises a counter ratchet member that is circularly shaped, coaxially arranged relative to the ratchet member, rotatable relative to the ratchet member at least along a first sense of rotation, and rotationally supported relative to the housing. The counter ratchet member comprises a counter ratchet surface, a plurality of counter ratchet features on the counter ratchet surface, and one or more intermediate counter ratchet sections.

Abstract: An autoinjector includes a housing and a drive chassis arranged linearly moveable within the housing. The drive chassis includes a dispensing limb and a trigger limb. The trigger limb and the dispensing limb are arranged in parallel to one another and are connected to one another at a respective distal end of the dispensing limb and the trigger limb.

Abstract: An autoinjector includes a pre-filled syringe arranged within a housing of the autoinjector, a needle shield covering a needle of the pre-filled syringe in a storage state of the autoinjector, an axially moveable needle guard arranged to cover the needle of the pre-filled syringe at least after use of the autoinjector and to move relative to the pre-filled syringe during use of the autoinjector, and a removable cap in which the needle guard is stored in the storage state of the autoinjector, Upon removal of the cap, the needle shield is also removed from the autoinjector.

Abstract: An autoinjector includes a housing, a needle guard mounted axially moveable in the housing for movement between a storage state, a dispensing state and a lock-out state in which states the needle guard adopts different axial positions relative to the housing, with the needle guard being configured to be axially moved in a proximal direction between the dispensing state and the lock-out state.

Abstract: An autoinjector includes a housing in which a pre-filled syringe is arranged, a drive chassis mounted in the housing, and a release mechanism. The drive chassis is biased with respect to the housing by a drive spring. The drive chassis is fixed with respect to the housing and with respect to movement relative to the housing in a storage state of the autoinjector. The release mechanism includes a trigger arm engaging a stop feature in the housing in the storage state of the autoinjector, and the trigger arm is configured to be disengaged from the stop feature upon activation of the autoinjector.

Abstract: An autoinjector basically includes a housing, a pre-filled syringe, a drive chassis, and a needle guard. The pre-filled syringe is mounted in the housing. The drive chassis is configured to move a plunger in the pre-filled syringe to dispense medicament via an urging force from a drive spring. The needle guard is moveable in the housing between a storage state, a dispensing state, and a lock-out state. The needle guard is biased towards an extended position by a lock-out spring. The needle guard selectively engages the housing to establish a frontmost position of the needle guard in the storage state, and an offset position of the needle guard in the lock-out state. The offset position is axially offset from the frontmost position in the distal direction.

Abstract: An autoinjector includes a housing, a prefilled syringe mounted in the housing, and a drive chassis mounted in the housing. The drive chassis biased with respect to the housing, and further being fixed with respect to the housing, and configured to move relative to the housing in a storage state of the autoinjector, the drive chassis moving relative to the housing upon dispensing a material from the pre-filled syringe. The autoinjector is configured to generate an audible end of dose feedback between the drive chassis and the housing as the autoinjector approaches the end of dispensing.

Abstract: An autoinjector includes a housing in which a pre-filled syringe is arranged, a drive chassis mounted in the housing, the drive chassis being biased with respect to the housing and being fixed with respect to the housing in a storage state of the autoinjector, a status indicator window and a syringe window both providing visible feedback to a user about a state of use of the autoinjector.

Abstract: The disclosure relates to an injection device for expelling of a number of preset or user-selectable doses of a medicament. The injection device includes an elongated housing extending along an axial direction and configured to accommodate a cartridge containing the medicament and having a bung sealing a proximal end of the cartridge, a windup expelling mechanism, and a dose setting mechanism. The dose setting mechanism includes a handle, a dose tracking member, and a limiter. The dose tracking member is rotatable relative to the housing within a range of positional states and operatively connectable to the handle for tracking a rotation thereof. The limiter is operationally engageable with the dose tracking member and a trigger of the windup expelling mechanism for blocking actuation of the trigger when the dose tracking member is in one of a number of predetermined sections of the range of positional states.

Abstract: The disclosure relates to a drug delivery device for expelling a pre-determined or pre-settable amount of a liquid medicament formulation which improves the stalling behavior and indicates the stalling state to the user. The device comprises: a medicament reservoir attached to a housing and an expelling mechanism configured for acting against the medicament reservoir in order to expel a portion of the liquid medicament formulation therefrom, the expelling mechanism comprising an arrangement of a threaded nut in a fixed axial relation to the housing and a lead screw in threaded engagement with the threaded nut, the threaded nut and the lead screw being rotatable relative to each other by a rotational input interface, a mechanical energy reservoir (for storing energy, the stored energy being releasable from the energy reservoir by a rotational interface, a drive train having upstream and downstream interfaces; and a trigger movable relative to the housing.

Abstract: High-yield mammalian transient expression systems can include a cell culture media (particularly serum free, non-animal derived, and/or chemically defined media) for introducing macromolecules and compounds (e.g., nucleic acid molecules) into cells (e.g., eukaryotic cells). Cells containing such introduced materials can then be cultured in the cell culture media. In particular, the invention allows introduction of nucleic acid molecules (e.g., vectors) into cells (particularly mammalian cells) and expression of proteins encoded by the nucleic acid molecules in the cells. The invention obviates the need to change the cell culture medium each time a different procedure is performed with the cells (e.g., culturing cells vs. transfecting cells). The invention also relates to compositions and kits useful for culturing and transforming/transfecting cells.

Abstract: A drug delivery device comprising a housing body; a piston rod configured to rotate in a rotational direction during dose dispensing under a driving force; and a threaded insert, wherein the piston rod is in threaded engagement with the threaded insert such that during the dose dispensing. the piston rod displaces axially in a distal direction relative to the threaded insert for displacement of a cartridge hung. The threaded insert is movable relative to a stop provided in the housing body and a spring is provided to bias the threaded insert against the stop so that the rotation of the piston rod causes the threaded insert to move away from the stop in response to reaction forces, induced by the cartridge bung into the threaded insert, acting on the piston rod in a proximal direction when the reaction forces exceed a biasing force of the spring.