Abstract: The present invention provides oligopeptides, in particular, Ang-(1-7) derivatives, and methods for using and producing the same. In one particular embodiment, oligopeptides of the invention have higher blood-brain barrier penetration and/or in vivo half-life compared to the native Ang-(1-7), thereby allowing oligopeptides of the invention to be used in a wide variety of clinical applications including in treatment of cognitive dysfunction and/of impairment.

Abstract: A drug delivery device for setting and dispensing doses of a liquid drug is described. The device includes a housing and a dose setting and drive mechanism with a dose setting member and a dose setting drum. The dose setting and drive mechanism is configured to perform a dose setting operation for setting a dose to be delivered by the drug delivery device by rotating the dose setting member relative to the housing and a dose delivery operation for delivering the set dose during rotation of the dose setting drum relative to dose setting member the housing. The dose setting drum includes an array of encoder features at its proximal end. The dose setting member has at least one aperture located in a proximal end surface that is coincident with at least a portion of the array of encoder features of the dose setting drum.

Abstract: The present disclosure relates to a drug delivery device for setting and dispensing doses of a liquid drug. The device comprises a housing and a dose setting and drive mechanism with a dose setting member. The dose setting and drive mechanism is, at least partially, arranged within the housing and is configured to perform a dose setting operation for selecting a dose to be delivered by the drug delivery device by moving the dose setting member relative to the housing and a dose delivery operation for delivering the set dose by axially displacing the dose setting member along an axis. The maximum radial extension perpendicular to the axis of the dose setting member is smaller than the maximum radial extension of a region of the housing located adjacent to the dose setting member.

Abstract: The present disclosure refers to a drug delivery device for setting and dispensing doses of a liquid drug which may be used together with a module for detecting the amount of a dose selected and/or delivered. The device comprises a housing and a dose setting and drive mechanism with a dose setting member. The dose setting and drive mechanism is configured to perform a dose setting operation for selecting a dose to be delivered by rotating the dose setting member relative to the housing and a dose delivery operation for delivering the set dose by pushing the dose setting member axially towards the housing without relative rotation therebetween. The dose setting member comprises a set of axially directed stop teeth formed at its distal end which are configured to engage with a set of counterstop teeth located on the housing at the end of the dose delivery operation.

Abstract: A drug delivery device for setting and dispensing doses of a liquid drug. The device comprises a housing and a dose setting and drive mechanism with a dose setting member and a dose setting drum. The dose setting and drive mechanism is configured to perform a dose setting operation for selecting a dose to be delivered, and a dose delivery operation for delivering the set dose. The dose setting drum comprises a set of clutch teeth that are engagable with a mating set of teeth on the dose setting member. The clutch teeth and the mating teeth are engaged during a dose setting operation to prevent rotation therebetween and the clutch teeth and the mating teeth are disengaged during a dose delivery operation allowing relative rotation between the dose setting drum and the dose setting member. The clutch teeth are formed on an external surface of the dose setting drum.

Abstract: An autoinjector includes a needle guard mounted axially moveable in the housing for movement between a storage state, a dispensing state and a lock-out state in which states the needle guard adopts different axial positions relative to the housing, with the needle guard being configured to be axially moved in a proximal direction between the dispensing state and the lock-out state.

Abstract: An autoinjector includes a housing in which a pre-filled syringe is arranged, a drive chassis mounted in the housing, the drive chassis being biased with respect to the housing by a drive spring, the drive chassis further being fixed with respect to the housing and with respect to a movement relative to the housing in a storage state of the autoinjector, the autoinjector including a release mechanism, the release mechanism comprising a trigger arm engaging a stop feature present in the housing in the storage state of the autoinjector, and the trigger arm is to be disengaged from the stop feature on activation of the autoinjector.

Abstract: An autoinjector includes a pre-filled syringe arranged within a housing of the autoinjector, a needle shield covering a needle of the pre-filled syringe in a storage state of the autoinjector, an axially moveable needle guard arranged to cover the needle of the pre-filled syringe at least after use of the autoinjector and to move relative to the pre-filled syringe during use of the autoinjector, and a removable cap in which the needle guard is stored in the storage state of the autoinjector, and, on removal of the cap, the needle shield is removed from the autoinjector.

Abstract: An autoinjector includes a housing in which a pre-filled syringe is arranged, a drive chassis mounted in the housing, the drive chassis being biased with respect to the housing and being fixed with respect to the housing in a storage state of the autoinjector, a status indicator window and a syringe window both providing visible feedback to a user about a state of use of the autoinjector.

Abstract: An autoinjector includes a housing and a drive chassis arranged linearly moveable within the housing, the drive chassis including a dispensing limb and a trigger limb, wherein the trigger limb and the dispensing limb are arranged in parallel to one another respectively at least essentially in parallel to one another and are connected to one another at a respective distal end of the dispensing limb and the trigger limb.

Abstract: A sensor device removably attachable to a drug delivery device includes a sensing arrangement arranged within the sensor device and circuitry configured to process signals provided by the sensing arrangement. The sensing arrangement is configured such that, when the sensor device is attached to the drug delivery device, the sensing arrangement is operable to read encoded information present on a rotatable component internal to the drug delivery device and that is able to be sensed through a window or aperture of the drug delivery device, and is operable to sense through the window or aperture at least a part of a drive mechanism of the drug delivery device. The circuitry is configured to determine information relating to a set dose, and to determine information relating to whether the drug delivery device is in a dose setting mode or whether the device is in a dose delivery mode.

Abstract: The disclosure relates to a dose setting and drive mechanism for a drug delivery device. In one aspect, the dose setting and drive mechanism comprises a stationary housing, a dial sleeve axially constrained to the stationary housing and rotatable relative to the stationary housing, and a button configured to switch between a dose setting mode and a dose dispensing mode, where the button comprises a first clutch interface configured to rotationally couple and de-couple the button and the stationary housing, and a second clutch interface configured to rotationally couple and de-couple the button and the dial sleeve, a driven member that is axially movable relative to the stationary housing, a drive member axially constrained to the stationary housing and coupled to the driven member in a manner such that rotation of the drive member in a dose dispensing direction is translated into axial displacement of the driven member.

Abstract: A method for tailoring mechanical properties of a photopolymer includes providing an active monomer feedstock, adding a sulfur-free chain transfer agent (CTA) to the active monomer feedstock to form a mixture, and curing the mixture under predetermined conditions. The sulfur-free CTA includes a Cobalt(II) complex or a Cobalt(III) complex, the mechanical properties include glass transition temperature, crosslinking density, and/or conversion rate, and a concentration of the sulfur-free CTA is less than 30% of the mixture. The predetermined conditions include intensity, wavelength, and application time of energy from a light source, a cure temperature, and/or the concentration of the sulfur-free CTA in the mixture. The method may further include adding a diluent to the mixture to modify a viscosity of the active monomer feedstock. The diluent may include one of a reactive diluent and a non-reactive diluent, such as methyl methacrylate (MMA) and methacrylate (MA).

Abstract: The present disclosure relates to a data logging device for monitoring an injection device, the injection device including a housing and a movable part movable between a first end position and a second end position, the data logging device including a trigger connectable to at least one of the movable part and the housing, a switch arrangement including a first switch engaged with the trigger and movable between a first trigger end position and a second trigger end position, the switch arrangement operable to switch between a first switching state and a second switching state upon movement of the trigger, and a processor connected to the switch arrangement and operable to detect a transition of the switch arrangement between the first switching state and the second switching state.

Abstract: The present disclosure refers to a drug delivery device and to a method of operating the same. The device includes a housing, a dial grip manually operable by a user for setting an individual dose to be delivered by the device, a dose setting and drive mechanism, a clutch including two clutch members for rotationally coupling and de-coupling the dial grip to the housing and/or to the dose setting and drive mechanism, at least one processor, a sensor arrangement operable to generate measurement data indicative of the dose setting operation, and a power source connected to the at least one processor. The drug delivery device includes a clutch actuator operable by the at least one processor to trigger a switch of the state of the clutch. The at least one processor is configured to operate the clutch actuator if the measurement data generated by the sensor arrangement reaches a threshold.

Abstract: A drive train for a wind-up injection device is described. The drive train includes a torsional energy storage adapted to be loaded or unloaded by a rotatable element, a rotatable user handle, a rotationally driveable expelling mechanism adapted to expel the liquid drug, and a clutch element coupled with the torsional energy storage via the rotatable element and including a ratchet for maintaining the rotatable element at one of a number of discrete angular positions against the torque of the torsional energy storage. The clutch element is adapted to transmit the torque from the user handle to the torsional energy storage, or alternatively from the torsional energy storage to the expelling mechanism. The ratchet is switchable from one position to an adjacent position by a torque transmitted from the user handle to the torsional energy storage. The drive train is adapted to dampen torque peaks visco-elastically and/or visco-frictionally.

Abstract: The present invention refers to an electronic encoder module (100) for use with a drug delivery device (1) for recording doses that are delivered from the drug delivery device (1) or with a charging station (200). The electronic module comprises a rechargeable electrical power supply (103), a memory, a processor with a PCBA (102) configured to control operation of the electronic module and coupled to the electrical power supply (103) and to the memory, at least one sensor arrangement (104) and a coupling portion for releasably mounting the electronic module (100) to the drug delivery device (1) when it is not mounted to a charging station (200) or to the charging station (200) when it is not mounted to the drug delivery device (1). At least one electrical power transfer component (107) is located within the coupling portion and connected to the PCBA (102) and/or to the rechargeable electrical power supply (103).

Abstract: The present disclosure refers to an electronic system for a drug delivery device. The electronic system may comprise an electrical power supply, a memory, a processor configured to control operation of the electronic system and coupled to the electrical power supply and to the memory, and two optical sensor units. The electronic system haa a first low-power-consumption state and at least one further state having a higher power consumption compared with the first state. The processor is configured to regularly poll both optical sensors in the first low-power-consumption state, to maintain the first low-power-consumption state if the response of both optical sensors is identical to each other and identical to the preceding response, and to switch into the at least one further state if the responses of the optical sensors are different from each other or are different from the preceding response.

Abstract: A button for a drug delivery device with a reduced operating loudness includes a plate-like button body forming a touch surface, wherein the plate-like button body is coupled by an axial supporting member to a noise-generating interface of the drug delivery device and movable into a longitudinal direction of the drug delivery device, wherein the plate-like button body includes a material composite with at least one first component consisting of a first material and at least one second component consisting of a second material different from the first material, wherein the at least one first component and the at least one second component are coupled via at least one coupling plane that is at least section wise slanted or perpendicular to the longitudinal direction. Further, the disclosure describes a button assembly for a drug delivery device which is shock resistant.

Abstract: An autoinjector basically includes a housing, a pre-filled syringe, a drive chassis, and a needle guard. The pre-filled syringe is mounted in the housing. The drive chassis is configured to move a plunger in the pre-filled syringe to dispense medicament via an urging force from a drive spring. The needle guard is moveable in the housing between a storage state, a dispensing state, and a lock-out state. The needle guard is biased towards an extended position by a lock-out spring. The needle guard selectively engages the housing to establish a frontmost position of the needle guard in the storage state, and an offset position of the needle guard in the lock-out state. The offset position is axially offset from the frontmost position in the distal direction.