Abstract: The disclosure relates to a dose setting and drive mechanism for a drug delivery device. In one aspect, the dose setting and drive mechanism comprises a stationary housing, a dial sleeve axially constrained to the stationary housing and rotatable relative to the stationary housing, and a button configured to switch between a dose setting mode and a dose dispensing mode, where the button comprises a first clutch interface configured to rotationally couple and de-couple the button and the stationary housing, and a second clutch interface configured to rotationally couple and de-couple the button and the dial sleeve, a driven member that is axially movable relative to the stationary housing, a drive member axially constrained to the stationary housing and coupled to the driven member in a manner such that rotation of the drive member in a dose dispensing direction is translated into axial displacement of the driven member.

Abstract: The present invention provides oligopeptides, in particular, Ang-(1-7) derivatives, and methods for using and producing the same. In one particular embodiment, oligopeptides of the invention have higher blood-brain barrier penetration and/or in vivo half-life compared to the native Ang-(1-7), thereby allowing oligopeptides of the invention to be used in a wide variety of clinical applications including in treatment of cognitive dysfunction and/of impairment.

Abstract: A method for tailoring mechanical properties of a photopolymer includes providing an active monomer feedstock, adding a sulfur-free chain transfer agent (CTA) to the active monomer feedstock to form a mixture, and curing the mixture under predetermined conditions. The sulfur-free CTA includes a Cobalt(II) complex or a Cobalt(III) complex, the mechanical properties include glass transition temperature, crosslinking density, and/or conversion rate, and a concentration of the sulfur-free CTA is less than 30% of the mixture. The predetermined conditions include intensity, wavelength, and application time of energy from a light source, a cure temperature, and/or the concentration of the sulfur-free CTA in the mixture. The method may further include adding a diluent to the mixture to modify a viscosity of the active monomer feedstock. The diluent may include one of a reactive diluent and a non-reactive diluent, such as methyl methacrylate (MMA) and methacrylate (MA).

Abstract: The present disclosure relates to a data logging device for monitoring an injection device, the injection device including a housing and a movable part movable between a first end position and a second end position, the data logging device including a trigger connectable to at least one of the movable part and the housing, a switch arrangement including a first switch engaged with the trigger and movable between a first trigger end position and a second trigger end position, the switch arrangement operable to switch between a first switching state and a second switching state upon movement of the trigger, and a processor connected to the switch arrangement and operable to detect a transition of the switch arrangement between the first switching state and the second switching state.

Abstract: The present disclosure refers to a drug delivery device and to a method of operating the same. The device includes a housing, a dial grip manually operable by a user for setting an individual dose to be delivered by the device, a dose setting and drive mechanism, a clutch including two clutch members for rotationally coupling and de-coupling the dial grip to the housing and/or to the dose setting and drive mechanism, at least one processor, a sensor arrangement operable to generate measurement data indicative of the dose setting operation, and a power source connected to the at least one processor. The drug delivery device includes a clutch actuator operable by the at least one processor to trigger a switch of the state of the clutch. The at least one processor is configured to operate the clutch actuator if the measurement data generated by the sensor arrangement reaches a threshold.

Abstract: A drive train for a wind-up injection device is described. The drive train includes a torsional energy storage adapted to be loaded or unloaded by a rotatable element, a rotatable user handle, a rotationally driveable expelling mechanism adapted to expel the liquid drug, and a clutch element coupled with the torsional energy storage via the rotatable element and including a ratchet for maintaining the rotatable element at one of a number of discrete angular positions against the torque of the torsional energy storage. The clutch element is adapted to transmit the torque from the user handle to the torsional energy storage, or alternatively from the torsional energy storage to the expelling mechanism. The ratchet is switchable from one position to an adjacent position by a torque transmitted from the user handle to the torsional energy storage. The drive train is adapted to dampen torque peaks visco-elastically and/or visco-frictionally.

Abstract: The present disclosure refers to an electronic system for a drug delivery device. The electronic system may comprise an electrical power supply, a memory, a processor configured to control operation of the electronic system and coupled to the electrical power supply and to the memory, and two optical sensor units. The electronic system haa a first low-power-consumption state and at least one further state having a higher power consumption compared with the first state. The processor is configured to regularly poll both optical sensors in the first low-power-consumption state, to maintain the first low-power-consumption state if the response of both optical sensors is identical to each other and identical to the preceding response, and to switch into the at least one further state if the responses of the optical sensors are different from each other or are different from the preceding response.

Abstract: The present invention refers to an electronic encoder module (100) for use with a drug delivery device (1) for recording doses that are delivered from the drug delivery device (1) or with a charging station (200). The electronic module comprises a rechargeable electrical power supply (103), a memory, a processor with a PCBA (102) configured to control operation of the electronic module and coupled to the electrical power supply (103) and to the memory, at least one sensor arrangement (104) and a coupling portion for releasably mounting the electronic module (100) to the drug delivery device (1) when it is not mounted to a charging station (200) or to the charging station (200) when it is not mounted to the drug delivery device (1). At least one electrical power transfer component (107) is located within the coupling portion and connected to the PCBA (102) and/or to the rechargeable electrical power supply (103).

Abstract: A button for a drug delivery device with a reduced operating loudness includes a plate-like button body forming a touch surface, wherein the plate-like button body is coupled by an axial supporting member to a noise-generating interface of the drug delivery device and movable into a longitudinal direction of the drug delivery device, wherein the plate-like button body includes a material composite with at least one first component consisting of a first material and at least one second component consisting of a second material different from the first material, wherein the at least one first component and the at least one second component are coupled via at least one coupling plane that is at least section wise slanted or perpendicular to the longitudinal direction. Further, the disclosure describes a button assembly for a drug delivery device which is shock resistant.

Abstract: An autoinjector basically includes a housing, a pre-filled syringe, a drive chassis, and a needle guard. The pre-filled syringe is mounted in the housing. The drive chassis is configured to move a plunger in the pre-filled syringe to dispense medicament via an urging force from a drive spring. The needle guard is moveable in the housing between a storage state, a dispensing state, and a lock-out state. The needle guard is biased towards an extended position by a lock-out spring. The needle guard selectively engages the housing to establish a frontmost position of the needle guard in the storage state, and an offset position of the needle guard in the lock-out state. The offset position is axially offset from the frontmost position in the distal direction.

Abstract: A drive train for a wind-up injection device is described. The drive train includes a torsional energy storage adapted to be loaded or unloaded by a rotatable element, a rotatable user handle, a rotationally driveable expelling mechanism adapted to expel the liquid drug, and a clutch element coupled with the torsional energy storage via the rotatable element and including a ratchet for maintaining the rotatable element at one of a number of discrete angular positions against the torque of the torsional energy storage. The clutch element is adapted to transmit the torque from the user handle to the torsional energy storage, or alternatively from the torsional energy storage to the expelling mechanism. The ratchet is switchable from one position to an adjacent position by a torque transmitted from the user handle to the torsional energy storage. The drive train is adapted to dampen torque peaks visco-elastically and/or visco-frictionally.

Abstract: A button for a drug delivery device with a reduced operating loudness includes a plate-like button body forming a touch surface, wherein the plate-like button body is coupled by an axial supporting member to a noise-generating interface of the drug delivery device and movable into a longitudinal direction of the drug delivery device, wherein the plate-like button body includes a material composite with at least one first component consisting of a first material and at least one second component consisting of a second material different from the first material, wherein the at least one first component and the at least one second component are coupled via at least one coupling plane that is at least sectionwise slanted or perpendicular to the longitudinal direction. Further, the disclosure describes a button assembly for a drug delivery device which is shock resistant.

Abstract: A drive train for a wind-up injection device is described. The drive train includes a torsional energy storage adapted to be loaded or unloaded by a rotatable element, a rotatable user handle, a rotationally driveable expelling mechanism adapted to expel the liquid drug, and a clutch element coupled with the torsional energy storage via the rotatable element and including a ratchet for maintaining the rotatable element at one of a number of discrete angular positions against the torque of the torsional energy storage. The clutch element is adapted to transmit the torque from the user handle to the torsional energy storage, or alternatively from the torsional energy storage to the expelling mechanism. The ratchet is switchable from one position to an adjacent position by a torque transmitted from the user handle to the torsional energy storage. The drive train is adapted to dampen torque peaks visco-elastically and/or visco-frictionally.

Abstract: A set including a pump dispenser for discharging pharmaceutical or cosmetic liquids and an external evaluation unit, which is designed to be exchangeable so that, after the pump dispenser has been emptied, the evaluation unit can be attached to a new pump dispenser. The evaluation unit can be attached to the discharging head of the pump dispenser such that the evaluation unit detects an actuation button and can be partially displaced with same. The evaluation unit can alternatively have a receiving container which is open on at least one side and into which the pump dispenser can be inserted and the force application of which is detected on actuation.

Abstract: An electronic module connectable to an autoinjector, the electronic module configured to detect and to monitor a dose administering process with the autoinjector or parameters related thereto and to provide a user of the autoinjector with feedback on the dose administering process or parameters related thereto.

Abstract: A set including a pump dispenser for discharging pharmaceutical or cosmetic liquids and an external evaluation unit, which is designed to be exchangeable so that, after the pump dispenser has been emptied, the evaluation unit can be attached to a new pump dispenser. The evaluation unit can be attached to the discharging head of the pump dispenser such that the evaluation unit detects an actuation button and can be partially displaced with same. The evaluation unit can alternatively have a receiving container which is open on at least one side and into which the pump dispenser can be inserted and the force application of which is detected on actuation.

Abstract: The disclosure relates to an injection device for expelling of a number of preset or user-selectable doses of a medicament. The injection device includes an elongated housing extending along an axial direction and configured to accommodate a cartridge containing the medicament and having a bung sealing a proximal end of the cartridge, a windup expelling mechanism, and a dose setting mechanism. The dose setting mechanism includes a handle , a dose tracking member, and a limiter. The dose tracking member is rotatable relative to the housing within a range of positional states and operatively connectable to the handle for tracking a rotation thereof. The limiter is operationally engageable with the dose tracking member and a trigger of the windup expelling mechanism for blocking actuation of the trigger when the dose tracking member is in one of a number of predetermined sections of the range of positional states.

Abstract: The present disclosure relates to a ratchet mechanism and to an injection device for expelling of a number of preset or user-selectable doses of a medicament. The ratchet mechanism comprises a housing and a ratchet member that is circularly shaped and rotationally supported relative to the housing. The ratchet member comprises a ratchet surface, a plurality of ratchet features on the ratchet surface, and one or more intermediate ratchet sections on the ratchet surface extending between the plurality of ratchet features. The ratchet mechanism further comprises a counter ratchet member that is circularly shaped, coaxially arranged relative to the ratchet member, rotatable relative to the ratchet member at least along a first sense of rotation, and rotationally supported relative to the housing. The counter ratchet member comprises a counter ratchet surface, a plurality of counter ratchet features on the counter ratchet surface, and one or more intermediate counter ratchet sections.

Abstract: An autoinjector includes a pre-filled syringe arranged within a housing of the autoinjector, a needle shield covering a needle of the pre-filled syringe in a storage state of the autoinjector, an axially moveable needle guard arranged to cover the needle of the pre-filled syringe at least after use of the autoinjector and to move relative to the pre-filled syringe during use of the autoinjector, and a removable cap in which the needle guard is stored in the storage state of the autoinjector, Upon removal of the cap, the needle shield is also removed from the autoinjector.

Abstract: An autoinjector includes a housing, a needle guard mounted axially moveable in the housing for movement between a storage state, a dispensing state and a lock-out state in which states the needle guard adopts different axial positions relative to the housing, with the needle guard being configured to be axially moved in a proximal direction between the dispensing state and the lock-out state.