Abstract: An autoinjector includes a needle guard mounted axially moveable in the housing for movement between a storage state, a dispensing state and a lock-out state in which states the needle guard adopts different axial positions relative to the housing, with the needle guard being configured to be axially moved in a proximal direction between the dispensing state and the lock-out state.

Abstract: An autoinjector includes a housing in which a pre-filled syringe is arranged, a drive chassis mounted in the housing, the drive chassis being biased with respect to the housing by a drive spring, the drive chassis further being fixed with respect to the housing and with respect to a movement relative to the housing in a storage state of the autoinjector, the autoinjector including a release mechanism, the release mechanism comprising a trigger arm engaging a stop feature present in the housing in the storage state of the autoinjector, and the trigger arm is to be disengaged from the stop feature on activation of the autoinjector.

Abstract: An autoinjector includes a pre-filled syringe arranged within a housing of the autoinjector, a needle shield covering a needle of the pre-filled syringe in a storage state of the autoinjector, an axially moveable needle guard arranged to cover the needle of the pre-filled syringe at least after use of the autoinjector and to move relative to the pre-filled syringe during use of the autoinjector, and a removable cap in which the needle guard is stored in the storage state of the autoinjector, and, on removal of the cap, the needle shield is removed from the autoinjector.

Abstract: An autoinjector includes a housing and a drive chassis arranged linearly moveable within the housing, the drive chassis including a dispensing limb and a trigger limb, wherein the trigger limb and the dispensing limb are arranged in parallel to one another respectively at least essentially in parallel to one another and are connected to one another at a respective distal end of the dispensing limb and the trigger limb.

Abstract: An autoinjector includes a housing in which a pre-filled syringe is arranged, a drive chassis mounted in the housing, the drive chassis being biased with respect to the housing and being fixed with respect to the housing in a storage state of the autoinjector, a status indicator window and a syringe window both providing visible feedback to a user about a state of use of the autoinjector.

Abstract: A set including a pump dispenser for discharging pharmaceutical or cosmetic liquids and an external evaluation unit, which is designed to be exchangeable so that, after the pump dispenser has been emptied, the evaluation unit can be attached to a new pump dispenser. The evaluation unit can be attached to the discharging head of the pump dispenser such that the evaluation unit detects an actuation button and can be partially displaced with same. The evaluation unit can alternatively have a receiving container which is open on at least one side and into which the pump dispenser can be inserted and the force application of which is detected on actuation.

Abstract: An electronic module connectable to an autoinjector, the electronic module configured to detect and to monitor a dose administering process with the autoinjector or parameters related thereto and to provide a user of the autoinjector with feedback on the dose administering process or parameters related thereto.

Abstract: An autoinjector basically includes a housing, a pre-filled syringe, a drive chassis, and a needle guard. The pre-filled syringe is mounted in the housing. The drive chassis is configured to move a plunger in the pre-filled syringe to dispense medicament via an urging force from a drive spring. The needle guard is moveable in the housing between a storage state, a dispensing state, and a lock-out state. The needle guard is biased towards an extended position by a lock-out spring. The needle guard selectively engages the housing to establish a frontmost position of the needle guard in the storage state, and an offset position of the needle guard in the lock-out state. The offset position is axially offset from the frontmost position in the distal direction.

Abstract: An autoinjector includes a housing in which a pre-filled syringe is arranged, a drive chassis mounted in the housing, the drive chassis being biased with respect to the housing and being fixed with respect to the housing in a storage state of the autoinjector, a status indicator window and a syringe window both providing visible feedback to a user about a state of use of the autoinjector.

Abstract: An autoinjector includes a pre-filled syringe arranged within a housing of the autoinjector, a needle shield covering a needle of the pre-filled syringe in a storage state of the autoinjector, an axially moveable needle guard arranged to cover the needle of the pre-filled syringe at least after use of the autoinjector and to move relative to the pre-filled syringe during use of the autoinjector, and a removable cap in which the needle guard is stored in the storage state of the autoinjector, Upon removal of the cap, the needle shield is also removed from the autoinjector.

Abstract: An autoinjector includes a housing, a needle guard mounted axially moveable in the housing for movement between a storage state, a dispensing state and a lock-out state in which states the needle guard adopts different axial positions relative to the housing, with the needle guard being configured to be axially moved in a proximal direction between the dispensing state and the lock-out state.

Abstract: An autoinjector includes a housing in which a pre-filled syringe is arranged, a drive chassis mounted in the housing, and a release mechanism. The drive chassis is biased with respect to the housing by a drive spring. The drive chassis is fixed with respect to the housing and with respect to movement relative to the housing in a storage state of the autoinjector. The release mechanism includes a trigger arm engaging a stop feature in the housing in the storage state of the autoinjector, and the trigger arm is configured to be disengaged from the stop feature upon activation of the autoinjector.

Abstract: An autoinjector includes a housing and a drive chassis arranged linearly moveable within the housing. The drive chassis includes a dispensing limb and a trigger limb. The trigger limb and the dispensing limb are arranged in parallel to one another and are connected to one another at a respective distal end of the dispensing limb and the trigger limb.

Abstract: A set including a pump dispenser for discharging pharmaceutical or cosmetic liquids and an external evaluation unit, which is designed to be exchangeable so that, after the pump dispenser has been emptied, the evaluation unit can be attached to a new pump dispenser. The evaluation unit can be attached to the discharging head of the pump dispenser such that the evaluation unit detects an actuation button and can be partially displaced with same. The evaluation unit can alternatively have a receiving container which is open on at least one side and into which the pump dispenser can be inserted and the force application of which is detected on actuation.

Abstract: High-yield mammalian transient expression systems can include a cell culture media (particularly serum free, non-animal derived, and/or chemically defined media) for introducing macromolecules and compounds (e.g., nucleic acid molecules) into cells (e.g., eukaryotic cells). Cells containing such introduced materials can then be cultured in the cell culture media. In particular, the invention allows introduction of nucleic acid molecules (e.g., vectors) into cells (particularly mammalian cells) and expression of proteins encoded by the nucleic acid molecules in the cells. The invention obviates the need to change the cell culture medium each time a different procedure is performed with the cells (e.g., culturing cells vs. transfecting cells). The invention also relates to compositions and kits useful for culturing and transforming/transfecting cells.

Abstract: The disclosure relates to a drug delivery device for mechanically dispensing a dose of a medicament. The drug delivery device includes a ratchet mechanism adapted to emit an audible and/or tactile feedback during dispensing the dose of medicament. The ratchet mechanism includes a flexible arm and a toothed profile. A free end of the flexible arm is configured to engage with the toothed profile and to perform a relative rotational movement thereto during dispensing the dose of medicament, thereby generating the audible and/or tactile feedback, and the flexible arm extends in a plane parallel to a rotational axis of the flexible arm.

Abstract: The disclosure provides a piston rod configured to engage a housing of a drug delivery device, wherein the piston rod comprises an outer thread that corresponds with an inner thread of the housing, characterized by a support element (that is configured as a supplement thread section of the outer thread, wherein the support element comprises a lead-in for assembly of the drug delivery device and wherein the lead-in is distally spaced from another lead-in arranged on the distal outer thread end. The disclosure further provides a drug delivery device comprising such a piston rod and a method for assembling such a drug delivery device.

Abstract: The present disclosure relates to a drug delivery device, comprising a housing, a cartridge, the cartridge containing a drug in a quantity sufficient for a plurality of doses of the drug, a bung, the bung being movably retained within the cartridge to dispense a dose of the drug from the cartridge upon movement of the bung with respect to the cartridge, and a drive mechanism, the drive mechanism being operable to transfer a driving force to the bung to dispense the dose of the drug from the cartridge. The drug delivery device is configured such that the maximal driving force which is transferrable to the bung via the drive mechanism varies and is adjusted to the current position of the bung within the cartridge.

Abstract: The present invention is directed generally to cell culture media (particularly serum free, non animal derived, and/or chemically defined media) which are useful for introducing macromolecules and compounds (e.g., nucleic acid molecules) into cells (e.g., eukaryotic cells). According to the invention, such introduction can take place in the presence of said medium. Cells containing such introduced materials can then be cultured in the medium and the effect of the introduced materials on the cells can be measured or determined. In particular, the invention allows introduction of nucleic acid molecules (e.g., vectors) into cells (particularly eukaryotic cells) and expression of proteins encoded by the nucleic acid molecules in the cells. The invention obviates the need to change the cell culture medium each time a different procedure is performed with the cells (e.g., culturing cells vs. transfecting cells).