Patents by Inventor Meredith L. Howell

Meredith L. Howell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and devices for immunizing a host through administration of naked polynucleotides with encode allergenic peptides
    Patent number: 5804566
    Abstract: The invention is directed to methods for introducing biologically active peptides into a host by administration of polynucleotides which operatively encode for the peptide of interest. In a preferred embodiment of the invention, a mammal is desensitized to an antigen, in particular an allergen, through administration to the mammal of polynucleotides which operatively encode the antigen. The antigen-encoding polynucleotides are administered to host tissues which have a high concentration of antigen presenting cells in them relative to other host tissues. The method is particularly useful in treating allergies because the allergen-encoding polynucleotides of the invention to induce tolerance while suppressing IgE antibody formation. Devices and compositions for use in the methods of the invention are also described.
    Type: Grant
    Filed: November 1, 1994
    Date of Patent: September 8, 1998
    Assignee: The Regents of the University of California
    Inventors: Dennis A. Carson, Eyal Raz, Meredith L. Howell