Patents by Inventor Merijn Louis Marten SALVERDA

Merijn Louis Marten SALVERDA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Surface display of antigens on Gram-negative outer membrane vesicles
    Patent number: 11040010
    Abstract: The present invention relates to vaccine compositions based on Gram-negative outer membrane vesicles displaying antigens of pathogens expressed as part of a fusion protein comprising N-terminal parts of surface expressed lipoproteins of Gram-negative bacteria, and use of such compositions in vaccination. The invention further relates to the fusion lipoproteins comprising N-terminal parts of surface expressed lipoproteins of Gram-negative bacteria and antigens of pathogens fused thereto, DNA constructs and bacterial host cells for expressing these fusion lipoproteins and to methods for producing outer membrane vesicles displaying the fusion lipoproteins.
    Type: Grant
    Filed: December 4, 2019
    Date of Patent: June 22, 2021
    Assignee: De Staat der Nederlanden, vert. door de minister van VWS, Ministerie van Volksgezondheid, Welzijn en Sport
    Inventors: Merijn Louis Marten Salverda, Peter André van der Ley
  • Surface display of antigens on Gram-negative outer membrane vesicles
    Publication number: 20200197308
    Abstract: The present invention relates to vaccine compositions based on Gram-negative outer membrane vesicles displaying antigens of pathogens expressed as part of a fusion protein comprising N-terminal parts of surface expressed lipoproteins of Gram-negative bacteria, and use of such compositions in vaccination. The invention further relates to the fusion lipoproteins comprising N-terminal parts of surface expressed lipoproteins of Gram-negative bacteria and antigens of pathogens fused thereto, DNA constructs and bacterial host cells for expressing these fusion lipoproteins and to methods for producing outer membrane vesicles displaying the fusion lipoproteins.
    Type: Application
    Filed: December 4, 2019
    Publication date: June 25, 2020
    Applicant: De Staat der Nerderlanden, vert. door de minister van VWS, Ministerie van Volksgerzondheid, Welzijn
    Inventors: Merijn Louis Marten Salverda, Peter André van der Ley
  • Surface display of antigens on gram-negative outer membrane vesicles
    Patent number: 10639280
    Abstract: The present invention relates to vaccine compositions based on Gram-negative outer membrane vesicles displaying antigens of pathogens expressed as part of a fusion protein comprising N-terminal parts of surface expressed lipoproteins of Gram-negative bacteria, and use of such compositions in vaccination. The invention further relates to the fusion lipoproteins comprising N-terminal parts of surface expressed lipoproteins of Gram-negative bacteria and antigens of pathogens fused thereto, DNA constructs and bacterial host cells for expressing these fusion lipoproteins and to methods for producing outer membrane vesicles displaying the fusion lipoproteins.
    Type: Grant
    Filed: June 2, 2016
    Date of Patent: May 5, 2020
    Assignee: DE STAAT DER NEDERLANDEN, VERT.DOOR DE MINISTER VAN VWS, MINISTERIE VAN VOLKSGEZONHEID, WELZIJN EN SPORT
    Inventors: Merijn Louis Marten Salverda, Peter André Van Der Ley
  • SURFACE DISPLAY OF ANTIGENS ON GRAM-NEGATIVE OUTER MEMBRANE VESICLES
    Publication number: 20180153808
    Abstract: The present invention relates to vaccine compositions based on Gram-negative outer membrane vesicles displaying antigens of pathogens expressed as part of a fusion protein comprising N-terminal parts of surface expressed lipoproteins of Gram-negative bacteria, and use of such compositions in vaccination. The invention further relates to the fusion lipoproteins comprising N-terminal parts of surface expressed lipoproteins of Gram-negative bacteria and antigens of pathogens fused thereto, DNA constructs and bacterial host cells for expressing these fusion lipoproteins and to methods for producing outer membrane vesicles displaying the fusion lipoproteins.
    Type: Application
    Filed: June 2, 2016
    Publication date: June 7, 2018
    Applicant: De Staat der Nederlanden, vert door de minster van VWS, Ministerie van Volksgezondheid, Welzijn en S
    Inventors: Merijn Louis Marten SALVERDA, Peter André VAN DER LEY