Patents by Inventor Meritxell Huch Ortega
Meritxell Huch Ortega has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20210317416Abstract: The invention relates to a liver organoid, uses thereof and method for obtaining them.Type: ApplicationFiled: March 3, 2021Publication date: October 14, 2021Applicant: Koninklijke Nederlandse Akademie van WetenschappenInventors: Meritxell Huch Ortega, Johannes Carolus Clevers
-
Patent number: 11034935Abstract: The invention relates to a liver organoid, uses thereof and method for obtaining them.Type: GrantFiled: July 31, 2017Date of Patent: June 15, 2021Assignee: Koninklijke Nederlandse Akademie van WetenschappenInventors: Meritxell Huch Ortega, Johannes Carolus Clevers
-
Patent number: 10947510Abstract: The invention relates to a method for culturing epithelial stem cells, isolated tissue fragments comprising said epithelial stem cells, or adenoma cells, and culturing the cells or fragments in the presence of a Bone Morphogenetic Protein (BMP) inhibitor, a mitogenic growth factor, and a Wnt agonist when culturing epithelial stem cells and isolated tissue fragments. The invention further relates to a cell culture medium comprising a BMP inhibitor, a mitogenic growth factor, and a Wnt agonist, to the use of said culture medium, and to crypt-villus organoids, gastric organoids and pancreatic organoids that are formed in said culture medium.Type: GrantFiled: November 13, 2013Date of Patent: March 16, 2021Assignee: Koninklijke Nederlandse Akademie Van WetenschappenInventors: Toshiro Sato, Johannes C. Clevers, Meritxell Huch Ortega
-
Publication number: 20200318063Abstract: The invention relates to improved culture methods for expanding epithelial stem cells and obtaining organoids, to culture media involved in said methods, and to uses of said organoids.Type: ApplicationFiled: June 19, 2020Publication date: October 8, 2020Applicant: Koninklijke Nederlandse Akademie Van WetenschappenInventors: Meritxell Huch Ortega, Johannes Carolus Clevers, Sylvia Fernandez Boj
-
Publication number: 20200172861Abstract: The invention relates to improved culture methods for expanding epithelial stem cells and obtaining organoids, to culture media involved in said methods, and to uses of said organoids.Type: ApplicationFiled: January 15, 2020Publication date: June 4, 2020Applicant: Koninklijke Nederlandse Akademie Van WetenschappenInventors: Meritxell Huch Ortega, Johannes Carolus Clevers, Sylvia Fernandez Boj
-
Patent number: 10597633Abstract: The invention relates to improved culture methods for expanding epithelial stem cells and obtaining organoids, to culture media involved in said methods, and to uses of said organoids.Type: GrantFiled: May 15, 2015Date of Patent: March 24, 2020Assignee: Koninklijke Nederlandse Akademie Van WetenschappenInventors: Meritxell Huch Ortega, Johannes Carolus Clevers, Sylvia Fernandez Boj
-
Publication number: 20190100728Abstract: The invention relates to a method for culturing epithelial stem cells, isolated tissue fragments comprising the epithelial stem cells, or adenoma cells, and culturing the cells or fragments in the presence of a Bone Morphogenetic Protein (BMP) inhibitor, a mitogenic growth factor, and a Wnt agonist when culturing epithelial stem cells and isolated tissue fragments. The invention further relates to a cell culture medium comprising a BMP inhibitor, a mitogenic growth factor, and a Wnt agonist, to the use of the culture medium, and to crypt-villus organoids, gastric organoids and pancreatic organoids that are formed in the culture medium.Type: ApplicationFiled: August 27, 2018Publication date: April 4, 2019Applicant: Koninklijke Nederlandse Akademie van WetenschappenInventors: Toshiro Sato, Johannes C. Clevers, Meritxell Huch Ortega
-
Publication number: 20180072995Abstract: The invention relates to a method for culturing epithelial stem cells, isolated tissue fragments comprising the epithelial stem cells, or adenoma cells, and culturing the cells or fragments in the presence of a Bone Morphogenetic Protein (BMP) inhibitor, a mitogenic growth factor, and a Wnt agonist when culturing epithelial stem cells and isolated tissue fragments. The invention further relates to a cell culture medium comprising a BMP inhibitor, a mitogenic growth factor, and a Wnt agonist, to the use of the culture medium, and to crypt-villus organoids, gastric organoids, pancreatic organoids, liver organoids, colon organoids, Barrett's Esophagus organoids, adenocarcinoma organoids and colon carcinoma organoids that are formed in the culture medium.Type: ApplicationFiled: July 19, 2017Publication date: March 15, 2018Applicant: Koninklijke Nederlandse Akademie van WetenschappenInventors: Toshiro Sato, Johannes C. Clevers, Meritxell Huch Ortega
-
Publication number: 20180066233Abstract: The invention relates to a liver organoid, uses thereof and method for obtaining them.Type: ApplicationFiled: July 31, 2017Publication date: March 8, 2018Applicant: Koninklijke Nederlandse Akademie van WetenschappenInventors: Meritxell Huch Ortega, Johannes Carolus
-
Patent number: 9765301Abstract: The invention relates to a liver organoid, uses thereof and method for obtaining them.Type: GrantFiled: July 29, 2011Date of Patent: September 19, 2017Assignee: Koninklijke Nederlandse Akademie van WetenschappenInventors: Meritxell Huch Ortega, Johannes Carolus Clevers
-
Patent number: 9752124Abstract: The invention relates to a method for culturing epithelial stem cells, isolated tissue fragments comprising the epithelial stem cells, or adenoma cells, and culturing the cells or fragments in the presence of a Bone Morphogenetic Protein (BMP) inhibitor, a mitogenic growth factor, and a Wnt agonist when culturing epithelial stem cells and isolated tissue fragments. The invention further relates to a cell culture medium comprising a BMP inhibitor, a mitogenic growth factor, and a Wnt agonist, to the use of the culture medium, and to crypt-villus organoids, gastric organoids, pancreatic organoids, liver organoids, colon organoids, Barrett's Esophagus organoids, adenocarcinoma organoids and colon carcinoma organoids that are formed in the culture medium.Type: GrantFiled: July 29, 2011Date of Patent: September 5, 2017Assignee: Koninklijke Nederlandse Akademie van WetenschappenInventors: Toshiro Sato, Johannes C. Clevers, Meritxell Huch Ortega
-
Publication number: 20170191030Abstract: The invention relates to improved culture methods for expanding epithelial stem cells and obtaining organoids, to culture media involved in said methods, and to uses of said organoids.Type: ApplicationFiled: May 15, 2015Publication date: July 6, 2017Applicant: KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPENInventors: Meritxell HUCH ORTEGA, Johannes Carolus CLEVERS, Sylvia FERNANDEZ BOJ
-
Publication number: 20140256037Abstract: The invention relates to a method for culturing epithelial stem cells, isolated tissue fragments comprising said epithelial stem cells, or adenoma cells, and culturing the cells or fragments in the presence of a Bone Morphogenetic Protein (BMP) inhibitor, a mitogenic growth factor, and a Wnt agonist when culturing epithelial stem cells and isolated tissue fragments. The invention further relates to a cell culture medium comprising a BMP inhibitor, a mitogenic growth factor, and a Wnt agonist, to the use of said culture medium, and to crypt-villus organoids, gastric organoids and pancreatic organoids that are formed in said culture medium.Type: ApplicationFiled: November 13, 2013Publication date: September 11, 2014Applicant: Koninklijke Nederlandse Akademie van WetenschappenInventors: Toshiro Sato, Johannes C. Clevers, Meritxell Huch Ortega
-
Publication number: 20140243227Abstract: Culture media and methods for expanding and differentiating populations of stem cells and for obtaining organoids. Expanded cell populations and organoids obtainable by methods of the invention and their use in drug screening, toxicity assays and regenerative medicine.Type: ApplicationFiled: June 11, 2012Publication date: August 28, 2014Applicant: Koninklijke Nederlandse Akademie van WetenschappenInventors: Johannes C. Clevers, Toshiro Sato, Meritxell Huch Ortega, Wouter Richard
-
Publication number: 20130189327Abstract: The invention relates to a liver organoid, uses thereof and method for obtaining them.Type: ApplicationFiled: July 29, 2011Publication date: July 25, 2013Applicant: KONINKIJIKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPENInventors: Meritxell Huch Ortega, Johannes Carolus Clevers
-
Publication number: 20120196312Abstract: The invention relates to a method for culturing epithelial stem cells, isolated tissue fragments comprising the epithelial stem cells, or adenoma cells, and culturing the cells or fragments in the presence of a Bone Morphogenetic Protein (BMP) inhibitor, a mitogenic growth factor, and a Wnt agonist when culturing epithelial stem cells and isolated tissue fragments. The invention further relates to a cell culture medium comprising a BMP inhibitor, a mitogenic growth factor, and a Wnt agonist, to the use of the culture medium, and to crypt-villus organoids, gastric organoids, pancreatic organoids, liver organoids, colon organoids, Barrett's Esophagus organoids, adenocarcinoma organoids and colon carcinoma organoids that are formed in the culture medium.Type: ApplicationFiled: July 29, 2011Publication date: August 2, 2012Inventors: Toshiro Sato, Johannes C. Clevers, Meritxell Huch Ortega
-
Publication number: 20120028355Abstract: The invention relates to a method for culturing epithelial stem cells, isolated tissue fragments comprising the epithelial stem cells, or adenoma cells, and culturing the cells or fragments in the presence of a Bone Morphogenetic Protein (BMP) inhibitor, a mitogenic growth factor, and a Wnt agonist when culturing epithelial stem cells and isolated tissue fragments. The invention further relates to a cell culture medium comprising a BMP inhibitor, a mitogenic growth factor, and a Wnt agonist, to the use of the culture medium, and to crypt-villus organoids, gastric organoids and pancreatic organoids that are formed in the culture medium.Type: ApplicationFiled: February 3, 2010Publication date: February 2, 2012Applicant: Koninklijke Nederlandse Akademie van WetenschappenInventors: Toshiro Sato, Johannes Carolus Clevers, Meritxell Huch Ortega