Patents by Inventor Merja Penttila

Merja Penttila has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Protease deficient filamentous fungal cells and methods of use thereof
    Patent number: 11827891
    Abstract: The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells.
    Type: Grant
    Filed: November 18, 2021
    Date of Patent: November 28, 2023
    Assignee: VTT TECHNICAL RESEARCH CENTRE OF FINLAND LTD
    Inventors: Christopher Landowski, Anne Huuskonen, Juhani Saarinen, Ann Westerholm-Parvinen, Anne Kanerva, Jari Natunen, Anna-Liisa Hänninen, Noora Salovuori, Merja Penttilä, Markku Saloheimo
  • METHODS OF MAKING NON-WOVEN MATERIALS FROM MYCELIUM
    Publication number: 20230079850
    Abstract: The present invention relates to a method of making non-woven material from mycelium produced in a stirred submerged liquid culture. The present invention also relates to use of a crosslinking agent in making a non-woven material from mycelium produced in a stirred submerged liquid culture. In addition, the present invention relates to use of mixing in making a non-woven material from mycelium produced in a stirred submerged liquid culture. The present invention relates also to a mycelium based non-woven material, wherein the mycelium is produced in a stirred submerged liquid culture.
    Type: Application
    Filed: December 30, 2020
    Publication date: March 16, 2023
    Inventors: Geza SZILVAY, Christiane LAINE, Manuel ARIAS BARRANTES, Anniina SUHONEN, Harry BOER, Merja PENTTILÄ, Pauliina AHOKAS
  • PROTEASE DEFICIENT FILAMENTOUS FUNGAL CELLS AND METHODS OF USE THEREOF
    Publication number: 20220290165
    Abstract: The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells.
    Type: Application
    Filed: November 18, 2021
    Publication date: September 15, 2022
    Applicant: GLYKOS FINLAND OY
    Inventors: Christopher LANDOWSKI, Anne HUUSKONEN, Juhani SAARINEN, Ann WESTERHOLM-PARVINEN, Anne KANERVA, Jari NATUNEN, Anna-Liisa HÄNNINEN, Noora SALOVUORI, Merja PENTTILÄ, Markku SALOHEIMO
  • YEAST EXPRESSING CELLULASES FOR SIMULTANEOUS SACCHARIFICATION AND FERMENTATION USING CELLULOSE
    Publication number: 20210388398
    Abstract: The present invention is directed to cellulytic host cells. The host cells of the invention expressing heterologous cellulases and are able to produce ethanol from cellulose. According to the invention, host cells expressing a combination of heterologous cellulases can be used to produce ethanol from cellulose. In addition, multiple host cells expressing different heterologous cellulases can be co-cultured together and used to produce ethanol from cellulose. Furthermore, the invention demonstrates for the first time the ability of Kluyveromyces to produce ethanol from cellulose. The yeast strains and co-cultures of yeast strains of the invention can be used to produce ethanol on their own, or can also be used in combination with externally added cellulases to increase the efficiency of saccharification and fermentation processes.
    Type: Application
    Filed: December 22, 2020
    Publication date: December 16, 2021
    Inventors: John McBride, Elena Brevnova, Mark Mellon, Allan Froehlich, Kristen Deleault, Vineet Rajgarhia, Riaan Den Haan, Merja Penttila, Marja Ilmen, Matti Siika-Aho, Jaana Uusitalo, Emily A. Stonehouse, Alan Gilbert, Haowen Xu, Deidre Willies, John Bardsley, Anu Koivula, Sanni Voutilainen
  • Protease deficient filamentous fungal cells and methods of use thereof
    Patent number: 11180767
    Abstract: The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells.
    Type: Grant
    Filed: June 26, 2020
    Date of Patent: November 23, 2021
    Assignee: GLYKOS FINLAND OY
    Inventors: Christopher Landowski, Anne Huuskonen, Juhani Saarinen, Ann Westerholm-Parvinen, Anne Kanerva, Jari Natunen, Anna-Liisa Hänninen, Noora Salovuori, Merja Penttilä, Markku Saloheimo
  • Production of oxalyl-CoA, glyoxylate and/or glycolic acid
    Patent number: 11124810
    Abstract: The present invention relates to a method of converting oxalate to oxalyl-coA and/or oxalyl-coA to glyoxylate in a fungus and to a method of producing glycolic acid. Still, the present invention relates to a genetically modified fungus comprising increased enzyme activity associated with oxalyl-CoA. And furthermore, the present invention relates to use of the fungus of the present invention for producing oxalate, oxalyl-coA, glyoxylate and/or glycolic acid from a carbon substrate. Still furthermore, the present invention relates to a method of producing specific products and to a method of preparing the genetically modified fungus of the present invention.
    Type: Grant
    Filed: July 27, 2018
    Date of Patent: September 21, 2021
    Assignee: Teknologian tutkimuskeskus VTT Oy
    Inventors: Mervi Toivari, Marja Ilmén, Merja Penttilä
  • PROTEASE DEFICIENT FILAMENTOUS FUNGAL CELLS AND METHODS OF USE THEREOF
    Publication number: 20210139922
    Abstract: The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells.
    Type: Application
    Filed: June 26, 2020
    Publication date: May 13, 2021
    Applicant: GLYKOS FINLAND OY
    Inventors: Christopher LANDOWSKI, Anne HUUSKONEN, Juhani SAARINEN, Ann WESTERHOLM-PARVINEN, Anne KANERVA, Jari NATUNEN, Anna-Liisa HÄNNINEN, Noora SALOVUORI, Merja PENTTILÄ, Markku SALOHEIMO
  • Protease deficient filamentous fungal cells and methods of use thereof
    Patent number: 10731168
    Abstract: The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells.
    Type: Grant
    Filed: January 18, 2019
    Date of Patent: August 4, 2020
    Assignee: GLYKOS FINLAND OY
    Inventors: Christopher Landowski, Anne Huuskonen, Juhani Saarinen, Ann Westerholm-Parvinen, Anne Kanerva, Jari Natunen, Anna-Liisa Hänninen, Noora Salovuori, Merja Penttilä, Markku Saloheimo
  • IMPROVED PRODUCTION OF OXALYL-COA, GLYOXYLATE AND/OR GLYCOLIC ACID
    Publication number: 20200199632
    Abstract: The present invention relates to a method of converting oxalate to oxalyl-coA and/or oxalyl-coA to glyoxylate in a fungus and to a method of producing glycolic acid. Still, the present invention relates to a genetically modified fungus comprising increased enzyme activity associated with oxalyl-CoA. And furthermore, the present invention relates to use of the fungus of the present invention for producing oxalate, oxalyl-coA, glyoxylate and/or glycolic acid from a carbon substrate. Still furthermore, the present invention relates to a method of producing specific products and to a method of preparing the genetically modified fungus of the present invention.
    Type: Application
    Filed: July 27, 2018
    Publication date: June 25, 2020
    Inventors: Mervi Toivari, Marja Ilmén, Merja Penttilä
  • PROTEASE DEFICIENT FILAMENTOUS FUNGAL CELLS AND METHODS OF USE THEREOF
    Publication number: 20190233831
    Abstract: The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells.
    Type: Application
    Filed: January 18, 2019
    Publication date: August 1, 2019
    Applicant: GLYKOS FINLAND OY
    Inventors: Christopher Landowski, Anne Huuskonen, Juhani Saarinen, Ann Westerholm-Parvinen, Anne Kanerva, Jari Natunen, Anna-Liisa Hänninen, Noora Salovuori, Merja PENTTILÄ, Markku Saloheimo
  • Protease deficient filamentous fungal cells and methods of use thereof
    Patent number: 10240159
    Abstract: The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells.
    Type: Grant
    Filed: December 12, 2016
    Date of Patent: March 26, 2019
    Assignee: Glykos Finland OY
    Inventors: Christopher Landowski, Anne Huuskonen, Juhani Saarinen, Ann Westerholm-Parvinen, Anne Kanerva, Jari Natunen, Anna-Liisa Hanninen, Noora Salovuori, Merja Penttila, Markku Saloheimo
  • YEAST EXPRESSING CELLULASES FOR SIMULTANEOUS SACCHARIFICATION AND FERMENTATION USING CELLULOSE
    Publication number: 20180258449
    Abstract: The present invention is directed to cellulytic host cells. The host cells of the invention expressing heterologous cellulases and are able to produce ethanol from cellulose. According to the invention, host cells expressing a combination of heterologous cellulases can be used to produce ethanol from cellulose. In addition, multiple host cells expressing different heterologous cellulases can be co-cultured together and used to produce ethanol from cellulose. Furthermore, the invention demonstrates for the first time the ability of Kluyveromyces to produce ethanol from cellulose. The yeast strains and co-cultures of yeast strains of the invention can be used to produce ethanol on their own, or can also be used in combination with externally added cellulases to increase the efficiency of saccharification and fermentation processes.
    Type: Application
    Filed: May 21, 2018
    Publication date: September 13, 2018
    Inventors: John McBride, Elena Brevnova, Mark Mellon, Allan Froehlich, Kristen Deleault, Vineet Rajgarhia, Riaan Den Haan, Merja Penttila, Marja Ilmen, Matti Siika-Aho, Jaana Uusitalo, Emily A. Stonehouse, Alan Gilbert, Haowen Xu, Deidre Willies, John Bardsley, Anu Koivula, Sanni Voutilainen
  • Yeast expressing cellulases for simultaneous saccharification and fermentation using cellulose
    Patent number: 9988652
    Abstract: The present invention is directed to cellulytic host cells. The host cells of the invention expressing heterologous cellulases and are able to produce ethanol from cellulose. According to the invention, host cells expressing a combination of heterologous cellulases can be used to produce ethanol from cellulose. In addition, multiple host cells expressing different heterologous cellulases can be co-cultured together and used to produce ethanol from cellulose. Furthermore, the invention demonstrates for the first time the ability of Kluveryomyces to produce ethanol from cellulose. The yeast strains and co-cultures of yeast strains of the invention can be used to produce ethanol on their own, or can also be used in combination with externally added cellulases to increase the efficiency of saccharification and fermentation processes.
    Type: Grant
    Filed: July 1, 2015
    Date of Patent: June 5, 2018
    Assignees: Lallemand Hungary Liquidity Management LLC, Stellenbosch University
    Inventors: John McBride, Elena Brevnova, Mark Mellon, Allan Froehlich, Kristen Deleault, Vineet Rajgarhia, Riaan Den Haan, Merja Penttila, Marja Ilmen, Matti Siika-Aho, Jaana Uusitalo, Emily A. Stonehouse, Alan Gilbert, Haowen Xu, Deidre Willes, John Bardsley, Anu Koivula, Sanni Voutilainen
  • Eukaryotic cell and method for producing glycolic acid
    Patent number: 9783809
    Abstract: The present invention concerns a eukaryotic host selected from microorganisms, and a method for producing glycolic acid using said eukaryotic host cells, especially cells of a genetically modified fungal host. Further this invention relates to a glycolic acid product obtained using the method described here and the use of genetically modified microorganism cells in production of glycolic acid.
    Type: Grant
    Filed: October 4, 2012
    Date of Patent: October 10, 2017
    Assignee: Teknologian tutkimuskeskus VTT Oy
    Inventors: Outi Koivistoinen, Joosu Kuivanen, Peter Richard, Merja Penttilä
  • Protease Deficient Filamentous Fungal Cells and Methods of Use Thereof
    Publication number: 20170275634
    Abstract: The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells.
    Type: Application
    Filed: December 12, 2016
    Publication date: September 28, 2017
    Applicant: Glykos Finland OY
    Inventors: Christopher Landowski, Anne Huuskonen, Juhani Saarinen, Ann Westerholm-Parvinen, Anne Kanerva, Jari Natunen, Anna-Liisa Hanninen, Noora Salovuori, Merja Penttila, Markku Saloheimo
  • Genetically modified yeast species, and fermentation processes using genetically modified yeast
    Patent number: 9758799
    Abstract: Yeast cells are transformed with an exogenous xylose isomerase gene. Additional genetic modifications enhance the ability of the transformed cells to ferment xylose to ethanol or other desired fermentation products. Those modifications include deletion of non-specific or specific aldose reductase gene(s), deletion of xylitol dehydrogenase gene(s) and/or overexpression of xylulokinase.
    Type: Grant
    Filed: July 5, 2016
    Date of Patent: September 12, 2017
    Assignee: Cargill Incorporated
    Inventors: Vineet Rajgarhia, Kari Koivuranta, Merja Penttila, Marja Ilmen, Pirkko Suominen, Aristos Aristidou, Christopher Kenneth Miller, Stacey Olson, Laura Ruohonen
  • Production of fucosylated glycoproteins
    Patent number: 9695454
    Abstract: Described herein are compositions including filamentous fungal cells, such as Trichoderma fungal cells, having reduced protease activity and expressing fucosylation pathway. Further described herein are methods for producing a glycoprotein having fucosylated N-glycan, using genetically modified filamentous fungal cells, for example, Trichoderma fungal cells, as the expression system.
    Type: Grant
    Filed: May 23, 2013
    Date of Patent: July 4, 2017
    Assignee: GLYKOS FINLAND OY
    Inventors: Jari Natunen, Ann Westerholm-Parvinen, Hanna Salo, Jussi Joensuu, Heli Viskari, Christopher Landowski, Anne Huuskonen, Anne Kanerva, Anna-Liisa Hanninen, Noora Salovuori, Merja Penttila, Juhani Saarinen, Markku Saloheimo
  • Method for improved protein production in filamentous fungi
    Patent number: 9695430
    Abstract: The present invention relates to a method for genetically modifying a filamentous fungus host for improved protein production. The method comprises that a filamentous fungus host is genetically modified to overexpress or to be deficient of specific genes. The invention relates also to the modified hosts. Furthermore, the invention relates to a method for improved production or for producing an improved composition of proteins, such as cellulases, hemicellulases, other proteins involved in the degradation of lignocellulosic material, or other proteins, in a filamentous fungus host.
    Type: Grant
    Filed: December 21, 2015
    Date of Patent: July 4, 2017
    Assignee: Teknologian Tutkimuskeskus VTT OY
    Inventors: Tiina Pakula, Markku Saloheimo, Mari Hakkinen, Ann Westerholm-Parvinen, Merja Penttila, Marika Vitikainen
  • GENETICALLY MODIFIED FUNGI AND THEIR USE IN LIPID PRODUCTION
    Publication number: 20170088842
    Abstract: The invention refers to fungal cells, and especially to oleaginous fungal cells that have been genetically modified to produce enzymes of the pyruvate dehydrogenase bypass route to enhance their lipid production. Especially the cells are modified to overexpress genes encoding pyruvate decarboxylase (PDC), acetaldehyde dehydrogenase (ALD) and/or acetyl-CoA synthetase (ACS), optionally together with a gene encoding diacylglycerol acyltransferase (DAT), or to express genes encoding PDC together with ALD and/or ACS. Methods of producing lipids, biofuels and lubricants using the modified fungi are also disclosed as well as expression cassettes useful therein. A new enzyme having phosholipid:diacylglycerol acyltransferase (PDAT) activity and a polynucleotide encoding it are also disclosed, which are useful in the lipid production. A recombinant Cryptococcus cell and its construction is described.
    Type: Application
    Filed: December 9, 2016
    Publication date: March 30, 2017
    Applicant: TEKNOLOGIAN TUTKIMUSKESKUS VTT
    Inventors: Kari KOIVURANTA, Laura RUOHONEN, Merja PENTTILÄ
  • Protease deficient filamentous fungal cells and methods of use thereof
    Patent number: 9567596
    Abstract: The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells.
    Type: Grant
    Filed: January 4, 2013
    Date of Patent: February 14, 2017
    Assignee: Glykos Finland OY
    Inventors: Christopher Landowski, Anne Huuskonen, Juhani Saarinen, Ann Westerholm-Parvinen, Anne Kanerva, Jari Natunen, Anna-Liisa Hanninen, Noora Salovuori, Merja Penttila, Markku Saloheimo