Patents by Inventor Merle Ratsep

Merle Ratsep has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • inducia DSM 21379 as enhancer of cellular immunity, hypocholesterolemic and anti-oxidative agent and antimicrobial agent against
    Patent number: 10272122
    Abstract: A microorganism strain Lactobacillus plantarum Inducia DSM 21379 for use as hypocholesterolemic, antimicrobial and anti-oxidative agent and as enhancer of the natural defense potential of a subject. L. plantarum Inducia is used for reducing the level of LDL-cholesterol in blood for preventing the cholesterol metabolism disorders and cardiovascular disorders. L. plantarum Inducia enhances simultaneously the natural defense potential and cellular immunity, and as anti-oxidative agent enhances anti-oxidative activity of blood by reducing the level of oxidized low density lipoprotein (ox-LDL). The strain is also used as an antimicrobial agent for lowering risk of Clostridium difficile associated diarrhea (CDAD) by preventing germination of C. difficile spores and by suppressing proliferation of its vegetative cells. The compositions comprising L. plantarum Inducia decrease the levels of LDL-cholesterol and ox-LDL in blood, enhance the natural defense potential and lower risk of CDAD.
    Type: Grant
    Filed: April 19, 2016
    Date of Patent: April 30, 2019
    Assignee: BIOCC OÜ
    Inventors: Marika Mikelsaar, Epp Songisepp, Pirje Hütt, Imbi Smidt, Kai Truusalu, Merle Rätsep, Siiri Koljalg, Jelena Stsepetova, Kalle Kilk, Mihkel Zilmer, Epp Sepp, Raik-Hiio Mikelsaar
  • LACTOBACILLUS PLANTARUM INDUCIA DSM 21379 AS ENHANCER OF CELLULAR IMMUNITY, HYPOCHOLESTEROLEMIC AND ANTI-OXIDATIVE AGENT AND ANTIMICROBIAL AGENT AGAINST CLOSTRIDIUM DIFFICILE
    Publication number: 20160296570
    Abstract: A microorganism strain Lactobacillus plantarum Inducia DSM 21379 for use as hypocholesterolemic, antimicrobial and anti-oxidative agent and as enhancer of the natural defense potential of a subject. L. plantarum Inducia is used for reducing the level of LDL-cholesterol in blood for preventing the cholesterol metabolism disorders and cardiovascular disorders. L. plantarum Inducia enhances simultaneously the natural defense potential and cellular immunity, and as anti-oxidative agent enhances anti-oxidative activity of blood by reducing the level of oxidized low density lipoprotein (ox-LDL). The strain is also used as an antimicrobial agent for lowering risk of Clostridium difficile associated diarrhoeae (CDAD) by preventing germination of C. difficile spores and by suppressing proliferation of its vegetative cells. The compositions comprising L. plantarum Inducia decrease the levels of LDL-cholesterol and ox-LDL in blood, enhance the natural defense potential and lower risk of CDAD.
    Type: Application
    Filed: April 19, 2016
    Publication date: October 13, 2016
    Applicant: TERVISLIKU PllMA BIOTEHNOLOOGIATE ARENDUSKESKUS OÜ (BIO-COMPETENCE CENTRE OF
    Inventors: Marika Mikelsaar, Epp Songisepp, Pirje Hütt, lmbi Smidt, Kai Truusalu, Merle Rätsep, Siiri Koljalg, Jelena Stsepetova, Kalle Kilk, Mihkel Zilmer, Epp Sepp, Raik-Hiio Mikelsaar
  • LACTOBACILLUS PLANTARUM INDUCIA DSM 21379 AS ENHANCER OF CELLULAR IMMUNITY, HYPOCHOLESTEROLEMIC AND ANTI-OXIDATIVE AGENT AND ANTIMICROBIAL AGENT AGAINST CLOSTRIDIUM DIFFICILE
    Publication number: 20140335066
    Abstract: A microorganism strain Lactobacillus plantarum Inducia DSM 21379 for use as hypocholesterolemic, antimicrobial and anti-oxidative agent and as enhancer of the natural defense potential of a subject. L. plantarum Inducia is used for reducing the level of LDL-cholesterol in blood for preventing the cholesterol metabolism disorders and cardiovascular disorders. L. plantarum Inducia enhances simultaneously the natural defense potential and cellular immunity, and as anti-oxidative agent enhances anti-oxidative activity of blood by reducing the level of oxidized low density lipoprotein (ox-LDL). The strain is also used as an antimicrobial agent for lowering risk of Clostridium difficile associated diarrhoeae (CDAD) by preventing germination of C. difficile spores and by suppressing proliferation of its vegetative cells. The compositions comprising L. plantarum Inducia decrease the levels of LDL-cholesterol and ox-LDL in blood, enhance the natural defense potential and lower risk of CDAD.
    Type: Application
    Filed: April 3, 2014
    Publication date: November 13, 2014
    Applicant: TERVISLIKU PIIMA BIOTEHNOLOOGIATE ARENDUSKESKUS OÜ (BIO-COMPETENCE CENTRE OF
    Inventors: Marika Mikelsaar, Epp Songisepp, Pirje Hütt, Imbi Smidt, Kai Truusalu, Merle Rätsep, Siiri Kõljalg, Jelena Stsepetova, Kalle Kilk, Mihkel Zilmer, Epp Sepp, Raik-Hiio Mikelsaar
  • ANTIMICROBIAL AND ANTIHYPERTENSIVE PROBIOTIC COMPOSITION, FOOD PRODUCT AND DIETARY SUPPLEMENT COMPRISING MICROORGANISM STRAIN LACTOBACILLUS PLANTARUM TENSIA DSM 21380 AND METHOD FOR SUPPRESSING CONTAMINATING MICROBES IN A FOOD PRODUCT
    Publication number: 20140328814
    Abstract: The present invention relates to an antimicrobial and antihypertensive probiotic compositions comprising microorganism strain Lactobacillus plantarum Tensia DSM 21380, e.g. food or pharmaceutical compositions or a dietary supplement compositions, food products (dairy products, e.g. fermented products or cheese). The invention also relates to method for suppressing pathogens and non-starter lactobacilli in food product and method for extension of shelf life of food product by the means of Lactobacillus plantarum Tensia DSM 21380.
    Type: Application
    Filed: June 12, 2014
    Publication date: November 6, 2014
    Applicant: Oü Tervisliku Piima Biotehnoloogiate Arenduskeskus (Bio-Competence Centre of
    Inventors: Epp Songisepp, Marika Mikelsaar, Merle Rätsep, Mihkel Zilmer, Pirje Hütt, Meeme Utt, Kristi Zilmer, Janne Uksti, Siiri Kõljalg
  • Isolated microorganism strains Lactobacillus plantarum MCC1 DSM 23881 and Lactobacillus gasseri MCC2 DSM 23882 and their use
    Publication number: 20140037792
    Abstract: The present invention relates to new microorganism strains L. plantarum MCC1 DSM 23881 and L. gasseri MCC2 DSM 23882 and their use as antioxidant proteolytic ingredients for the production of food products and dietary supplements. Food products and dietary supplements containing L. plantarum MCC1 and L. gasseri MCC2 are hypoallergenic, reduce milk allergy and lower urinary tract irritation symptoms accompanying benign prostatic hyperplasia and oxidative stress and inflammation associated with these.
    Type: Application
    Filed: February 23, 2012
    Publication date: February 6, 2014
    Applicant: Bio-Competence Centre of Healthy Dairy Products
    Inventors: Ene Tammsaar, Kersti Ehrlich, Kersti Zilmer, Lauri Bobrovski, Marika Mikelsaar, Margus Punab, Mihkel Zilmer, Maire Vasar, Merle Ratsep, Tiiu Kullisaar, Epp Songisepp, Andre Veskioja
  • Isolated Microorganism Strain Lactobacillus Plantarum Tensia DSM 21380 as Antimicrobial and Antihypertensive Probiotic, Food Product and Composition Comprising Said Microorganism and Use of Said Microorganism for Preparation of Antihypertensive Medicine and Method for Suppressing Pathogens and Non-Starter Lactobacilli in Food Product
    Publication number: 20110177198
    Abstract: The present invention relates to a microorganism strain Lactobacillus plantarum Tensia DSM 21380 as antimicrobial and antihypertensive probiotic, food products (dairy products, e.g. fermented products or cheese) and composition comprising said microorganism and use of said microorganism for production of antihypertensive medicine. The invention also relates to a method for suppressing pathogens and nonstarter lactobacilli in food product and a method for extension of shelf life of food product by the means of Lactobacillus plantarum Tensia DSM 21380.
    Type: Application
    Filed: May 12, 2009
    Publication date: July 21, 2011
    Applicant: OU Tervisliku PIIMa Biotehnologiate Arenduskeskus (Biocompetence Centre of Healthy Diary Products)
    Inventors: Epp Songisepp, Marika Mikelsaar, Merle Ratsep, Mihkel Zilmer, Pirje Hutt, Meeme Utt, Kersti Zilmer, Janne Uksti, Siiri Koljalg