Abstract: Disclosed herein is a medical device for extended release of drugs. The device is a self-retaining implantable drug delivery device embedded with one or more drug depots that release of a therapeutic agent in a controlled manner. Each end of the self-retaining implantable drug delivery device may contain one or more anchors or attachment points which enable self-retention of the medical device once properly placed. The device can also comprise one or more drug depots with a swellable or non-swellable anchor. The disclosed devices further comprises a biosensor to monitor physiological characteristics like, e.g., intraocular pressure (IOP).

Abstract: Disclosed herein is a medical device for extended release of drugs. The device comprises a stent embedded with one or more drug depots that release of a therapeutic agent in a controlled manner. Each end of the stent may contain one or more anchors or attachment points which enable self-retention of the medical device once properly placed. The disclosed device further comprises a biosensor to monitor physiological characteristics like, e.g., intraocular pressure (IOP).

Abstract: The present invention relates broadly to the field of sustained release formulations. More specifically, the invention describes compositions and methods relating to formulating proteins and/or peptides with purified gallic acid esters. In one example, the gallic acid ester is PentaGalloylGlucose (PGG) and in anther example the gallic acid ester is epigallocatechin gallate (EGCG).

Abstract: The present invention relates to the preparation of polyol/thickened oil suspensions containing a biologically active agent, for the sustained delivery of the biologically active agent. The described protein/glycerol/oil suspensions show sustained release of protein, e.g., G-CSF, of up to at least one week.

Abstract: The present invention relates broadly to the field of sustained release formulations. More specifically, the invention describes compositions and methods relating to formulating proteins and/or peptides with purified gallic acid esters. In one example, the gallic acid ester is PentaGalloylGlucose (PGG) and in anther example the gallic acid ester is epigallocatechin gallate (EGCG).

Abstract: The present invention relates to the preparation of polyol/thickened oil suspensions containing a biologically active agent, for the sustained delivery of the biologically active agent. The described protein/glycerol/oil suspensions show sustained release of protein, e.g., G-CSF, of up to at least one week.

Abstract: The instant invention relates to vinylic macromers containing perfluoropolyalkylether and polyalklether segments, polymers and ophthalmic devices such as intraocular implants and contact lenses and particularly soft hydrogel contact lenses made therefrom.

Abstract: The instant invention relates to crosslinked copolymers of (a) vinylic macromers containing perfluoropolyalkylether and polyalkylether segments with (b) minor amounts of vinylic comonomers and ophthalmic devices such as intraocular implants and contact lenses and particularly soft hydrogel contact lenses made therefrom.

Abstract: The instant invention relates to vinylic macromers containing perfluoropolyalkylether and polyalkylether segments, polymers and ophthalmic devices such as intraocular implants and contact lenses and particularly soft hydrogel contact lenses made therefrom.

Abstract: A contact lens of a crosslinked, organic aprotic solvent insoluble, substantially transparent polymer of a derivative of a polyvinyl alcohol having a weight average molecular weight of at least about 2,000, containing an effective amount between about 0.1 to 90 percent, based on the number of hydroxyl groups on said polyvinyl alcohol, of a crosslinked addition reaction product of units of the formula ##STR1## in the presence or absence of a polymerizable vinylic monomer whereinR.sub.1 is a divalent aliphatic, cycloaliphatic, arylene, aralkylene, alkarylene or heterocyclic group;A is --O--, --NH-- or ##STR2## where R" is hydrogen or lower alkyl and A' is a direct bond or A is a direct bond and A' is --O-- or --O--CH.sub.2 --;R.sub.2 is hydrogen or methyl; andR.sub.3 is hydrogen, methyl or --COOR.sub.4 where R.sub.4 is hydrogen or lower alkyl with the proviso that if R.sub.2 is methyl, R.sub.3 is hydrogen.

Abstract: The instant invention relates to vinylic macromers containing perfluoropolyalkylether and polyalkylether segments, polymers and ophthalmic devices such as intraocular implants and contact lenses and particularly soft hydrogel contact lenses made therefrom.

Abstract: The instant invention relates to crosslinked copolymers of (a) vinylic macromers containing perfluoropolyalkylether and polyalkylether segments with (b) minor amounts of vinylic comonomers and ophthalmic devices such as intraocular implants and contact lenses and particularly soft hydrogel contact lenses made therefrom.

Abstract: A contact lens possessing a wettable surface in its aqueous environment of use fabricated from a hydrophobic addition polymer incorporating between about 0.5 and about 30% weight oxirane substituted units in the backbone thereof, wherein the outer surfaces of said lens contain an effective hydrophilic inducing amount of a reaction product of said oxirane substituted units of the formula ##STR1## wherein R is hydrogen or methyl;R.sub.1 is ##STR2## or lower alkylene; n is 1 to 4; andR.sub.0 is hydrogen or ##STR3## with a water soluble reactive organic amine, alcohol, thiol, urea or thiourea or a sulfite, bisulfite or thiosulfate, and the use thereof by placement in the eye of a patient in need of the same to correct vision defects of a refractive nature.

Abstract: Organic aprotic solvent soluble polymers which are derivatives of a polyvinyl alcohol, having a weight average molecular weight of at least about 2,000, and containing from about 0.5 to about 90 percent, based on the number of hydroxyl groups in said polyvinyl alcohol, of units of the formula ##STR1## wherein R.sub.1 and R.sub.2 are independently alkylene, arylene, cycloaliphatic, aralkylene or aralkarylene, n is 0 or 1, A.sub.1 is a carbamoyloxy or ureido linking group, A is an oxa, imino or ureido group, R.sub.3 is hydrogen or methyl, R.sub.4 is hydrogen, or when R.sub.3 is hydrogen, methyl or also --COOR.sub.5 where R.sub.5 is hydrogen or lower alkyl, and crosslinked hydrogel contact lenses made therefrom and their preparation.

Abstract: Organic aprotic solvent soluble polymers which are derivatives of a polyvinyl alcohol, having a weight average molecular weight of at least about 2,000, and containing from about 0.5 to about 90 percent, based on the number of hydroxyl groups in said polyvinyl alcohol, of units of the formula ##STR1## wherein R.sub.1 and R.sub.2 are independently alkylene, arylene, cycloaliphatic, aralkylene or aralkarylene, n is 0 or 1, A.sub.1 is a carbamoyloxy or ureido linking group, A is an oxa, imino or ureido group, R.sub.3 is hydrogen or methyl, R.sub.4 is hydrogen, or when R.sub.3 is hydrogen, methyl or also -COOR.sub.5 where B.sub.5 is hydrogen or lower alkyl, and crosslinked hydrogel contact lenses made therefrom and their preparation.

Abstract: Organic aprotic solvent insoluble polymers which are derivatives of a polyvinyl alcohol, having a weight average molecular weight of at least about 2,000, and containing from about 0.5 to about 90 percent, based on the number of hydroxyl groups in said polyvinyl alcohol, of an addition reaction product of units of the formula ##STR1## with a vinylic monomer, wherein R.sub.1 and R.sub.2 are independently alkylene, arylene, cycloaliphatic, aralkylene or aralkarylene, n is 0 or 1, A.sub.1 is a carbamoyloxy or ureido linking group, A is an oxa, imino or ureido group, R.sub.3 is hydrogen or methyl, R.sub.4 is hydrogen, or when R.sub.3 is hydrogen, methyl or also --COOR.sub.5 where R.sub.5 is hydrogen or lower alkyl, and hydrogel contact lenses made therefrom and their preparation.

Abstract: Optically clear soft contact lenses of a polyoxirane crosslinked polyvinyl alcohol having a weight average molecular weight of at least 8,000 and degree of hydrolysis of at least 93% and their preparation are disclosed. The materials are characterized by their ability to be boiling water sterilized, and their high water content, high oxygen permeability and high optical clarity.