Patents by Inventor Merritt B. Andrus

Merritt B. Andrus has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10202410
    Abstract: The present disclosure relates to scaphopetalone analogs, methods of making the analogs, and their uses.
    Type: Grant
    Filed: September 30, 2016
    Date of Patent: February 12, 2019
    Assignee: Brigham Young University
    Inventors: Merritt B. Andrus, F. Brent Johnson, Mary Ruth Jaeger Greer, Rex G. Cates
  • Publication number: 20170152280
    Abstract: The present disclosure relates to scaphopetalone analogs, methods of making the analogs, and their uses.
    Type: Application
    Filed: September 30, 2016
    Publication date: June 1, 2017
    Inventors: Merritt B. Andrus, F. Brent Johnson, Mary Ruth Jaeger Greer, Rex G. Cates
  • Patent number: 8841477
    Abstract: The present invention includes methods for preparing resveratrol, resveratrol esters and substituted and unsubstituted stilbenes of the formula given below; where each Y is —O or halogen, each Z is —O or halogen, each n and each m is independently the value of 0, 1, 2, 3, 4 or 5, each A and each B is independently selected from Pn, R or absent, each V and each W is independently selected from Pn, straight or branched alkyl of from 2 to 6 carbon atoms and cycloalkyl of from 3 to 8 carbon atoms, alkoxy, phenyl, benzyl or halogen, R is independently selected from the group comprising alkyl with at least one carbon atom, aryl and aralkyl, Pn is an alcohol protecting group and diastereoisomers of the foregoing. The compounds are made from a multi-step process including a N-heterocyclic carbene-type ligand coupling in the presence of a base with benzyol halide and styrene coupling partners. These compounds show increased stability for use in the food, cosmetic and pharmaceutical industries.
    Type: Grant
    Filed: July 15, 2009
    Date of Patent: September 23, 2014
    Assignee: Brigham Young University
    Inventors: Merritt B. Andrus, Jing Liu
  • Publication number: 20130123357
    Abstract: The present invention relates to a method of providing enhanced resveratrol activity comprising: administering a therapeutically effective amount of 4-acetoxy-resveratrol for the treatment of and preventing physiological and pathophysiological conditions mediated by (1) sirtuins, (2) estrogen and anti-estrogen hormone actions and (3) chemical interventions important for male and female health, aging, anti-aging and age-related disorders.
    Type: Application
    Filed: April 13, 2011
    Publication date: May 16, 2013
    Applicant: BRIGHAM YOUNG UNIVERSITY
    Inventors: Edwin Douglas Lephart, Merritt B. Andrus
  • Publication number: 20100185006
    Abstract: The present invention includes methods for preparing resveratrol, resveratrol esters and substituted and unsubstituted stilbenes of the formula given below; where each Y is —O or halogen, each Z is —O or halogen, each n and each m is independently the value of 0, 1, 2, 3, 4 or 5, each A and each B is independently selected from Pn, R or absent, each V and each W is independently selected from Pn, straight or branched alkyl of from 2 to 6 carbon atoms and cycloalkyl of from 3 to 8 carbon atoms, alkoxy, phenyl, benzyl or halogen, R is independently selected from the group comprising alkyl with at least one carbon atom, aryl and aralkyl, Pn is an alcohol protecting group and diastereoisomers of the foregoing. The compounds are made from a multi-step process including a N-heterocyclic carbene-type ligand coupling in the presence of a base with benzyol halide and styrene coupling partners. These compounds show increased stability for use in the food, cosmetic and pharmaceutical industries.
    Type: Application
    Filed: July 15, 2009
    Publication date: July 22, 2010
    Applicant: Brigham Young University
    Inventors: Merritt B. Andrus, Jing Liu
  • Patent number: 7714161
    Abstract: The present invention includes methods for preparing resveratrol, resveratrol esters and substituted and unsubstituted stilbenes of the formula given below; where each Y is —O or halogen, each Z is —O or halogen, each n and each m is independently the value of 0, 1, 2, 3, 4 or 5, each A and each B is independently selected from Pn, R or absent, each V and each W is independently selected from Pn, straight or branched alkyl of from (2) to (6) carbon atoms and cycloalkyl of from (3) to (8) carbon atoms, alkoxy, phenyl, benzyl or halogen, R is independently selected from the group comprising alkyl with at least one carbon atom, aryl and aralkyl, Pn is an alcohol protecting group and diastereoisomers of the foregoing. The compounds are made from a multi-step process including a N-heterocyclic carbene-type ligand coupling in the presence of a base with benzyol halide and styrene coupling partners. These compounds show increased stability for use in the food, cosmetic and pharmaceutical industries.
    Type: Grant
    Filed: January 19, 2005
    Date of Patent: May 11, 2010
    Assignee: Brigham Young University
    Inventors: Merritt B. Andrus, Jing Liu
  • Publication number: 20080255382
    Abstract: The present invention includes methods for preparing resveratrol, resveratrol esters and substituted and unsubstituted stilbenes of the formula given below; where each Y is —O or halogen, each Z is —O or halogen, each n and each m is independently the value of 0, 1, 2, 3, 4 or 5, each A and each B is independently selected from Pn, R or absent, each V and each W is independently selected from Pn, straight or branched alkyl of from (2) to (6) carbon atoms and cycloalkyl of from (3) to (8) carbon atoms, alkoxy, phenyl, benzyl or halogen, R is independently selected from the group comprising alkyl with at least one carbon atom, aryl and aralkyl, Pn is an alcohol protecting group and diastereoisomers of the foregoing. The compounds are made from a multi-step process including a N-heterocyclic carbon-type ligand coupling in the presence of a base with benzyol halide and styrene coupling partners. These compounds show increased stability for use in the food, cosmetic and pharmaceutical industries.
    Type: Application
    Filed: January 19, 2005
    Publication date: October 16, 2008
    Inventors: Merritt B. Andrus, Jing Liu
  • Publication number: 20030008922
    Abstract: The present invention relates to a MDR reversal agent. The agent is polyvalent possessing two or more binding domains spaced to effectively inhibit the multiple drug resistance activity of Pgp. The MDR reversal agent is based upon the naturally occurring compound (−)-stipiamide. The multiple drug resistence reversal agent of the present invention can be a homodimer based on napthyl-DHS. The homodimer incorporates two napthyl-DHS domains joined by a series of joined ethylene glycol spacers. The invention also relates to method of reversing MDR in a human cell by administering the reversal agent of the invention. When Pgp is contacted with the reversal agent, the ATPase activity of Pgp is significantly reduced as well as the binding affinity of Pgp for its known substrates.
    Type: Application
    Filed: August 12, 2002
    Publication date: January 9, 2003
    Inventors: Merritt B. Andrus, Timothy M. Turner, John H. Prince