Patents by Inventor Merritt C. Maduke

Merritt C. Maduke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Lamb wave mode-conversion based biological stimulation device
    Publication number: 20230082180
    Abstract: Ultrasonic excitation to a sample is provided with an apparatus including: a cylindrical ultrasonic transducer, and a plate disposed on an end of the cylindrical ultrasonic transducer. The ultrasonic transducer is configured to provide a vertical vibration in operation. A Lamb wave vibration is generated in the plate by the vertical vibration of the ultrasonic transducer. The Lamb wave vibration converges at a central region of the plate, where a sample is disposed. Alternatively, a cylindrical array of ultrasonic transducers can be used instead of a single cylindrical transducer. Such an array can be driven as a phased array for beam shaping and/or multi-focusing.
    Type: Application
    Filed: September 12, 2022
    Publication date: March 16, 2023
    Inventors: Jeong Nyeon Kim, Kamyar Firouzi, Martin Loynaz Prieto, Merritt C. Maduke, Butrus T. Khuri-Yakub
  • Compositions and methods to modulate chloride ion channel activity
    Patent number: 11173137
    Abstract: Provided herein are small-molecules for use in modulating chloride ion channel (CLC) activity, particularly the activity of CLC-2, to elucidate the role of CLC-2 in disorders associated with CLC-2 malfunction, and to identify therapeutic leads for their treatment. Compositions and methods for modulating CLC activity are also provided. In certain aspects, the subject compounds and compositions are useful for imaging or channel pull-down studies.
    Type: Grant
    Filed: June 21, 2019
    Date of Patent: November 16, 2021
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Anna K. Koster, Justin Du Bois, Merritt C. Maduke
  • COMPOSITIONS AND METHODS TO MODULATE CHLORIDE ION CHANNEL ACTIVITY
    Publication number: 20200016103
    Abstract: Provided herein are small-molecules for use in modulating chloride ion channel (CLC) activity, particularly the activity of CLC-2, to elucidate the role of CLC-2 in disorders associated with CLC-2 malfunction, and to identify therapeutic leads for their treatment. Compositions and methods for modulating CLC activity are also provided. In certain aspects, the subject compounds and compositions are useful for imaging or channel pull-down studies.
    Type: Application
    Filed: June 21, 2019
    Publication date: January 16, 2020
    Inventors: Anna K. Koster, Justin Du Bois, Merritt C. Maduke