Abstract: Vanishing device or structure made of specifically-linked hydrogel that can be configured, via the linkage chemistry, for a number of different applications, including enrichment, retrieval, separation, and/or arrangement of a targeted agent within an environment and then to, additionally, fully dissolve under a pre-defined condition such as heat, body temperature, light, time, among other examples described herein for that application. The separation, and subsequent vanishing, allows for the isolation and/or enrichment of the targeted agent for subsequent analysis that would otherwise damage, degrade, or affect the target agent of interest. The separation can also arrange or retrieve the target agent in a structure that can then vanish to allow for the subsequent analysis of the target agent.

Abstract: Disclosed are methods and systems relating to removing cell clusters from blood samples.

Abstract: An embodiment of the disclosed technology provides an isolation device for isolating clustered particles. The isolation device can include an inlet configured to receive a fluid and an outlet configured to output the fluid. The fluid can include a plurality of non-clustered particles and a plurality of clustered particles. The isolation device can include a plurality of microwells. Each microwell can have a plurality of sidewalls and a bottom surfacing having a meshed trapping region. The meshed trapping region can capture the plurality of clustered particles while allowing the non-clustered particles to pass. The outputted fluid can include the plurality of non-clustered particle and be substantially free of the plurality of clustered particles.