Patents by Inventor Mervyn J. Monteiro

Mervyn J. Monteiro has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • UBIQUILIN REGULATION OF PRESENILIN ENDOPROTEOLYSIS, AND SUPPRESSION OF POLYGLUTAMINE-INDUCED TOXICITY IN CELLS
    Publication number: 20110166206
    Abstract: Use of ubiquilin is described, including utilization for reducing fragmentation of presenilin 1 and 2 and to modulate ?-secretase components, Pen-2 and Nicastrin, as well as utilization for inducing increased levels of ubiquilin to reduce aggregation of polyglutamine expansion proteins known to cause cell toxicity and cell death in subjects suffering from neurodegenerative diseases, such as Huntington's and Alzheimer's diseases.
    Type: Application
    Filed: April 19, 2006
    Publication date: July 7, 2011
    Applicant: UNIVERSITY OF MARYLAND BIOTECHNOLOGY INSTITUTE
    Inventors: Mervyn J. Monteiro, Hongmin Wang
  • REDUCTION OF POLYALANINE-INDUCED PROTEIN AGGREGATES AND TOXICITY BY UBIQUILIN
    Publication number: 20100099747
    Abstract: A method for decreasing cell death in a cell exhibiting aggregation of polyalanine-containing proteins. The method includes introduction of an expression vector to a host cell comprising a nucleotide sequence encoding ubiquilin, followed by maintaining the transformed host cell under biological conditions sufficient for expression and accumulation of the ubiquilin in the host cell, wherein overexpression of ubiquilin reduces sensitivity of cell stress induced by expanded polyalanine proteins.
    Type: Application
    Filed: December 21, 2007
    Publication date: April 22, 2010
    Applicant: UNIVERSITY OF MARYLAND BIOTECHNOLOGY INSTITUTE
    Inventors: Mervyn J. Monteiro, Hongmin Wang
  • Method of controlling the binding of calmyrin to presenilin
    Patent number: 6930169
    Abstract: The present invention describes a calcium-binding myristoylated protein with homology to calcineurin B which interacts preferentially with presenilin 2 protein. Also, the present invention relates to methods that alter protein-protein interaction of the calcium-binding myristoylated protein with presenilin 2 thereby reducing deleterious effects of the protein-protein interaction, such as apoptosis. The present invention further relates to introducing and expressing a mutant presenilin 2 protein or mutant calcium-binding myristoylated protein to modulate cell functions relating to calcium signaling and apoptosis.
    Type: Grant
    Filed: June 11, 2001
    Date of Patent: August 16, 2005
    Assignee: University of Baltimore Biotechnology Institute
    Inventors: Mervyn J. Monteiro, Stacy Stabler
  • Ubiquilin, a presenilin interactor and methods of using same
    Publication number: 20030175278
    Abstract: The present invention describes a human presenilin-interacting protein, ubiquilin, that modulates presenilin protein levels and is associated with neuropathological lesions such as neurofibrillary tangles and Lewy bodies in Alzheimer's disease and Parkinson's disease affected brains. Also, the present invention relates to anti-ubiquilin antibodies that prominently stain neurons. The present invention further relates to introducing and expressing ubiquilin to modulate cell functions relating to presenilin synthesis.
    Type: Application
    Filed: November 13, 2002
    Publication date: September 18, 2003
    Inventors: Mervyn J. Monteiro, Alex L. Mah, George Perry, Mark A. Smith
  • Method of controlling the binding of calmyrin to presenilin
    Publication number: 20020064828
    Abstract: The present invention describes a calcium-binding myristoylated protein with homology to calcineurin B which interacts preferentially with presenilin 2 protein. Also, the present invention relates to methods that alter protein-protein interaction of the calcium-binding myristoylated protein with presenilin 2 thereby reducing deleterious effects of the protein-protein interaction, such as apoptosis. The present invention further relates to introducing and expressing a mutant presenilin 2 protein or mutant calcium-binding myristoylated protein to modulate cell functions relating to calcium signaling and apoptosis.
    Type: Application
    Filed: June 11, 2001
    Publication date: May 30, 2002
    Inventors: Mervyn J. Monteiro, Stacy Stabler