Patents by Inventor Mervyn Maze

Mervyn Maze has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200123245
    Abstract: The present invention provides method, uses and agents for preventing or reducing cognitive decline in a patient following a planned inflammatory trigger. Such planned inflammatory trigger can be a surgical procedure or chemotherapy. The invention further provides methods, uses and agents for reducing cognitive decline in a patient with a cognitive disorder, wherein said patient has been exposed to an inflammatory trigger. Pharmaceutical compositions and kits are also provided.
    Type: Application
    Filed: October 23, 2019
    Publication date: April 23, 2020
    Applicant: The Kennedy Trust for Rheumatology Research
    Inventors: Mervyn Maze, Marc Feldmann, Noccolo Terrando, Mario Cibelli, Daqing Ma, Michael Fertleman
  • Publication number: 20190375704
    Abstract: Provided herein, inter alia, are compounds and methods useful for modulating the translational effects of eIF2? phosphorylation, the Integrated Stress Response (ISR), and the unfolded protein response (UPR); for treating diseases; for increasing protein production, and for improving long-term memory.
    Type: Application
    Filed: May 21, 2019
    Publication date: December 12, 2019
    Inventors: Peter Walter, Carmela Sidrauski, Diego Acosta Alvear, Michelle R. Arkin, Christopher G. Wilson, Kean Hooi Ang, Brian R. Hearn, Punitha Vedantham, Adam R. Renslo, Mervyn Maze, Susana Vacas
  • Patent number: 10343981
    Abstract: Provided herein, inter alia, are compounds and methods useful for modulating the translational effects of eIF2? phosphorylation, the Integrated Stress Response (ISR), and the unfolded protein response (UPR); for treating diseases; for increasing protein production, and for improving long-term memory.
    Type: Grant
    Filed: June 5, 2017
    Date of Patent: July 9, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Peter Walter, Carmela Sidrauski, Diego Acosta Alvear, Michelle R. Arkin, Christopher G. Wilson, Kean Hooi Ang, Brian R. Hearn, Punitha Vedantham, Adam R. Renslo, Mervyn Maze, Susana Vacas
  • Publication number: 20170342020
    Abstract: Provided herein, inter alia, are compounds and methods useful for modulating the translational effects of eIF2? phosphorylation, the Integrated Stress Response (ISR), and the unfolded protein response (UPR); for treating diseases; for increasing protein production, and for improving long-term memory.
    Type: Application
    Filed: June 5, 2017
    Publication date: November 30, 2017
    Inventors: Peter Walter, Carmela Sidrauski, Diego Acosta Alvear, Michelle R. Arkin, Christopher G. Wilson, Kean Hooi Ang, Brian R. Hearn, Punitha Vedantham, Adam R. Renslo, Mervyn Maze, Susana Vacas
  • Patent number: 9708247
    Abstract: Provided herein, inter alia, are compounds and methods useful for modulating the translational effects of eIF2? phosphorylation, the Integrated Stress Response (ISR), and the unfolded protein response (UPR); for treating diseases; for increasing protein production, and for improving long-term memory.
    Type: Grant
    Filed: September 9, 2015
    Date of Patent: July 18, 2017
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Peter Walter, Carmela Sidrauski, Diego Acosta Alvear, Michelle R. Arkin, Christopher G. Wilson, Kean Hooi Ang, Brian R. Hearn, Punitha Vedantham, Adam R. Renslo, Mervyn Maze, Susana Vacas
  • Publication number: 20160333088
    Abstract: The present invention provides method, uses and agents for preventing or reducing cognitive decline in a patient following a planned inflammatory trigger. Such planned inflammatory trigger can be a surgical procedure or chemotherapy. The invention further provides methods, uses and agents for reducing cognitive decline in a patient with a cognitive disorder, wherein said patient has been exposed to an inflammatory trigger. Pharmaceutical compositions and kits are also provided.
    Type: Application
    Filed: March 8, 2016
    Publication date: November 17, 2016
    Inventors: Mervyn Maze, Marc Feldman, Niccolo Terrando, Mario Cibelli, Daqing Ma, Michael Fertleman
  • Patent number: 9326996
    Abstract: The present invention relates to the use of xenon in the preparation of a medicament for preventing and/or alleviating one or more anesthetic-induced neurological deficits in a neonatal subject. The present invention further relates to combinations of xenon and sevoflurane, and use thereof as preconditioning agents for administration prior to hypoxic-ischaemic injury.
    Type: Grant
    Filed: February 10, 2015
    Date of Patent: May 3, 2016
    Inventors: Nicholas Peter Franks, Mervyn Maze
  • Patent number: 9308254
    Abstract: The present invention provides method, uses and agents for preventing or reducing cognitive decline in a patient following a planned inflammatory trigger. Such planned inflammatory trigger can be a surgical procedure or chemotherapy. The invention further provides methods, uses and agents for reducing cognitive decline in a patient with a cognitive disorder, wherein said patient has been exposed to an inflammatory trigger. Pharmaceutical compositions and kits are also provided.
    Type: Grant
    Filed: February 17, 2011
    Date of Patent: April 12, 2016
    Assignee: IMPERIAL INNOVATIONS LIMITED
    Inventors: Mervyn Maze, Marc Feldman, Niccolo Terrando, Mario Cibelli, Daqing Ma, Michael Fertleman
  • Publication number: 20160096800
    Abstract: Provided herein, inter alia, are compounds and methods useful for modulating the translational effects of eIF2? phosphorylation, the Integrated Stress Response (ISR), and the unfolded protein response (UPR); for treating diseases; for increasing protein production, and for improving long-term memory.
    Type: Application
    Filed: September 9, 2015
    Publication date: April 7, 2016
    Inventors: Peter Walter, Carmela Sidrauski, Diego Acosta Alvear, Michelle R. Arkin, Christopher G. Wilson, Kean Hooi Ang, Brian R. Hearn, Punitha Vedantham, Adam R. Renslo, Mervyn Maze, Susana Vacas
  • Publication number: 20150216897
    Abstract: The present invention relates to the use of xenon in the preparation of a medicament for preventing and/or alleviating one or more anesthetic-induced neurological deficits in a neonatal subject. The present invention further relates to combinations of xenon and sevoflurane, and use thereof as preconditioning agents for administration prior to hypoxic-ischaemic injury.
    Type: Application
    Filed: February 10, 2015
    Publication date: August 6, 2015
    Inventors: Nicholas Peter Franks, Mervyn Maze
  • Publication number: 20130084299
    Abstract: The present invention provides method, uses and agents for preventing or reducing cognitive decline in a patient following a planned inflammatory trigger. Such planned inflammatory trigger can be a surgical procedure or chemotherapy. The invention further provides methods, uses and agents for reducing cognitive decline in a patient with a cognitive disorder, wherein said patient has been exposed to an inflammatory trigger. Pharmaceutical compositions and kits are also provided.
    Type: Application
    Filed: February 17, 2011
    Publication date: April 4, 2013
    Applicant: IMPERIAL INNOVATIONS LIMITED
    Inventors: Mervyn Maze, Marc Feldman, Niccolo Terrando, Mario Cibelli, Daqing Ma, Michael Fertleman
  • Publication number: 20100316729
    Abstract: Noble gases, in particular xenon and/or helium, administered under hyperbaric conditions of less than 3 atm (0.3 MPa), are used to provide neuroprotection, in particular in patients having suffered an impact trauma to the head and/or spinal column.
    Type: Application
    Filed: April 9, 2008
    Publication date: December 16, 2010
    Applicant: AIR PRODUCTS AND CHEMICALS, INC.
    Inventors: Nicholas Peter Franks, Mervyn Maze, Juan Carlos Sacristan Martin
  • Publication number: 20090311340
    Abstract: The present invention relates to the use of xenon in the preparation of a medicament for preventing and/or alleviating one or more anesthetic-induced neurological deficits in a neonatal subject. The present invention further relates to combinations of xenon and sevoflurane, and use thereof as preconditioning agents for administration prior to hypoxic-ischaemic injury.
    Type: Application
    Filed: August 19, 2005
    Publication date: December 17, 2009
    Applicant: PROTEXEON LIMITED
    Inventors: Nicholas Peter Franks, Mervyn Maze
  • Patent number: 7632872
    Abstract: In a first aspect, the present invention relates to the use of xenon in the preparation of a medicament for providing analgesia in a newborn subject and/or a fetal subject. In a second aspect, the invention relates to a method of providing analgesia in a newborn subject, the method comprising administering to the subject a therapeutically effective amount of xenon. In a third aspect, the invention relates to a method of providing analgesia in a fetal subject, the method comprising administering to the mother of the fetal subject a therapeutically effective amount of xenon for both the mother and fetal subject.
    Type: Grant
    Filed: August 5, 2003
    Date of Patent: December 15, 2009
    Assignee: Protexeon Limited
    Inventors: Nicholas Peter Franks, Mervyn Maze
  • Publication number: 20090252814
    Abstract: Use of xenon is described. Xenon is used as an organ and/or tissue and/or cell protectant in the manufacture of a pharmaceutical for the protection from injury of organs and/or tissue and/or cells that express HIF.
    Type: Application
    Filed: October 3, 2006
    Publication date: October 8, 2009
    Inventors: Mervyn Maze, Patrick Henry Maxwell, David Edwards
  • Patent number: 7442383
    Abstract: The present invention relates to methods of controlling neurological deficits in patients who have undergone cardiopulmonary bypass (CPB) by administering xenon to said patients.
    Type: Grant
    Filed: May 1, 2003
    Date of Patent: October 28, 2008
    Assignee: Protexeon Limited
    Inventors: Nicholas Peter Franks, Mervyn Maze
  • Patent number: 7390508
    Abstract: The present invention relates to the use of xenon in the preparation of a medicament for the treatment of neonatal asphyxia in a neonatal subject, wherein said medicament is for use in combination with hypothermia.
    Type: Grant
    Filed: October 11, 2004
    Date of Patent: June 24, 2008
    Assignee: Protexeon Limited
    Inventors: Nicholas Peter Franks, Mervyn Maze
  • Publication number: 20070104796
    Abstract: The present invention relates to the use of xenon in the preparation of a medicament for the treatment of neonatal asphyxia in a neonatal subject, wherein said medicament is for use in combination with hypothermia.
    Type: Application
    Filed: October 11, 2004
    Publication date: May 10, 2007
    Applicant: PROTEXEON LIMITED
    Inventors: Nicholas Franks, Mervyn Maze
  • Publication number: 20060233885
    Abstract: In a first aspect, the present invention relates to the use of xenon in the preparation of a medicament for providing analgesia in a newborn subject and/or a fetal subject. In a second aspect, the invention relates to a method of providing analgesia in a newborn subject, the method comprising administering to the subject a therapeutically effective amount of xenon. In a third aspect, the invention relates to a method of providing analgesia in a fetal subject, the method comprising administering to the mother of the fetal subject a therapeutically effective amount of xenon for both the mother and fetal subject.
    Type: Application
    Filed: August 5, 2003
    Publication date: October 19, 2006
    Inventors: Nicholas Franks, Mervyn Maze
  • Publication number: 20050238726
    Abstract: The present invention relates to methods of controlling neurological deficits in patients who have undergone cardiopulmonary bypass (CPB) by administering xenon to said patients.
    Type: Application
    Filed: May 1, 2003
    Publication date: October 27, 2005
    Inventors: Nicholas Franks, Mervyn Maze