Abstract: Improved nucleic acid nanostructures provide a platform for stable and effective intra-cellular delivery of nucleic acids, suitably coding nucleic acids such as mRNA or ssDNA. A nucleic acid nanostructure is provided that comprises a first single stranded nucleic acid sequence that defines a scaffold sequence, wherein the scaffold sequence comprises at least one open reading frame that encodes a first gene product; and a plurality of single stranded nucleic acid sequences that define a plurality of staple sequences, wherein the plurality of staple sequences are capable of hybridising with one or more regions of the scaffold sequence in order to induce the formation of a geometrically defined higher order structure. The nanostructure may further comprise at least one membrane binding moiety, wherein the membrane binding moiety is configured to associate with a cell membrane.

Abstract: Tetrathiomolybdate is for use in therapy of a condition requiring reduced metabolism of an organ or whole body, e.g. myocardial infection, stroke or ischaemia-reperfusion injury.

Abstract: An apparatus for the determination and continuous monitoring of bladder epithelial oxygen (pbO.sub.2) which comprises, in combination, an introductory catheter with an inflatable placement cuff and an oxygen sensor, wherein the sensor is completely accommodated within the catheter when not in use and, when the apparatus is placed within a patient's bladder, the sensor is adapted to be deployed so that the distal end of the sensor passes through an open port in the distal wall of the catheter and extends beyond the tip of the catheter to rest against the wall of the bladder; and a method for the continuous monitoring of pbO.sub.2 using such apparatus.