Patents by Inventor Methvin Isaac

Methvin Isaac has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tetrazole compounds and their use as metabotropic glutamate receptor antagonists
    Publication number: 20070197549
    Abstract: The present invention relates to new compounds of formula I, wherein P, Q, X1, X2, X3, X4, R1, R2, m and p, are as defined as in formula I, or salts, solvates or solvated salts thereof, processes for their preparation and new intermediates used in the preparation thereof, pharmaceutical compositions containing said compounds, and to the use of said compounds in therapy.
    Type: Application
    Filed: February 17, 2005
    Publication date: August 23, 2007
    Applicant: AstraZeneca AB
    Inventors: Martin Johansson, Alexander Minidis, Karin Staaf, David Wensbo, Donald McLeod, Louise Edwards, Methvin Isaac, Anne O'Brien, Abdelmalik Slassi, Tao Xin, Tomislav Stefanac
  • Fused heterocyclic compounds and their use as metabotropic glutamate receptor antagonists
    Publication number: 20070185095
    Abstract: The present invention is directed to compounds of formula: (I); wherein X1, X2, X3, X4, X5, X6, X7, X8, X9, X10, R1, R2, R3, R4, and n are as defined for formula I in the description. The invention also relates to processes for the preparation of the compounds and to new intermediates employed in the preparation, pharmaceutical compositions containing the compounds, and to the use of the compounds for treating gastrointestinal disorders.
    Type: Application
    Filed: February 17, 2005
    Publication date: August 9, 2007
    Applicants: AstraZeneca AB, NPS PHARMACEUTICALS, INC.
    Inventors: Martin Johansson, David Wensbo, Alexander Minidis, Karin Staaf, Annika Kers, Louise Edwards, Methvin Isaac, Tomislav Stefanac, Abdelmalik Slassi, Donald McLeod, Tao Xin
  • Poly-heterocyclic compounds and their use as metabotropic glutamate receptor antagonists
    Publication number: 20070185100
    Abstract: The present invention relates to new compounds of formula (I), wherein P, Q, X1, X2, X3, X4, X5, X6, R1, R2, R3, m, n, and p are as defined as in formula (I), or salts, or hydrates thereof, processes for their preparation and new intermediates used in the preparation thereof, pharmaceutical compositions containing said compounds and to the use of said compounds in therapy.
    Type: Application
    Filed: February 17, 2005
    Publication date: August 9, 2007
    Applicant: AstraZeneca AB
    Inventors: Jalaj Arora, Louise Edwards, Methvin Isaac, Annika Kers, Karin Staaf, Abdelmalik Slassi, Tomislav Stefanac, David Wensbo, Tao Xin, Bjorn Holm
  • Triazole compounds and their use as metabotropic glutamate receptor antagonists
    Publication number: 20070185178
    Abstract: The present invention relates to new compounds of formula (I), wherein P, Q, X1, X2, X3, X4, X7, X8, R1, R2, R3, m, n, and p are as defined as in formula (I), or salts, or hydrates thereof, processes for their preparation and new intermediates used in the preparation thereof, pharmaceutical compositions containing said compounds and to the use of said compounds in therapy, especially for the treatment of mGluR5 receptor mediated disorders, and for the treatment of neurological disorders, psychiatric disorders, gastrointestinal disorders and pain disorders.
    Type: Application
    Filed: February 17, 2005
    Publication date: August 9, 2007
    Applicants: AatraZeneca AB, NPS PHARMACEUTICALS, INC.
    Inventors: Louise Edwards, Methvin Isaac, Martin Johansson, Johan Malmberg, Alexander Minidis, Karin Staaf, Abdelmalik Slassi, David Wensbo, Tao Xin, Tomislav Stefanac
  • Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
    Publication number: 20070179188
    Abstract: The present invention relates to new compounds of formula (I), to pharmaceutical formulations containing the compounds, and to the use of the compounds in the prevention and/or treatment of mGluR5 receptor-mediated disorders.
    Type: Application
    Filed: February 15, 2005
    Publication date: August 2, 2007
    Applicants: AstraZeneca AB, NPS PHARMACEUTICALS, INC.
    Inventors: Louise Edwards, Methvin Isaac, Martin Johansson, Annika Kers, Johan Malmberg, Donald Mcleod, Alexander Minidis, Karin Staaf, Abdelmalik Slassi, Tomislav Stefanac, Thomas Stormann, David Wensbo, Tao Xin, Jalaj Arora
  • New compounds for the treatment of neurological, psychiatric or pain disorders
    Publication number: 20070129408
    Abstract: The present invention is directed to novel compounds, their use in therapy and pharmaceutical compositions comprising said novel compounds.
    Type: Application
    Filed: September 20, 2006
    Publication date: June 7, 2007
    Applicants: AstraZeneca AB, NPS PHARMACEUTICALS, INC.
    Inventors: Alexander Minidis, David Wensbo, Methvin Isaac, Abdelmalik Slassi, Jalaj Arora, Tao Xin, Louise Edwards, Caroline Eriksson, Veronica Profir, Per-Olov Bergstrom
  • Cinnamamide compounds as metabotropic glutamate receptor antagonists
    Publication number: 20070049578
    Abstract: The invention relates to compounds of formula I or pharmaceutically acceptable salts or solvates thereof: where R1, R2, R3, A, X, and n are defined in the description. The invention also includes pharmaceutical compositions and uses of, and processes of making the compounds, as well as methods of medical treatment of mGluR 5 mediated disorders.
    Type: Application
    Filed: August 14, 2006
    Publication date: March 1, 2007
    Applicants: AstraZeneca AB, NPS PHARMACEUTICALS
    Inventors: Louise Edwards, Methvin Isaac, Abdelmalik Slassi, Tao Xin, Peter Dove
  • Acetylenic piperazines as metabotropic glutamate receptor antagonists
    Publication number: 20070037817
    Abstract: The invention relates to compounds of formula I or pharmaceutically acceptable salts or solvates thereof: where Ar1, A, B, R1, m and n are as defined in the description. The invention also includes pharmaceutical compositions and uses of, and processes of making the compounds, as well as methods of medical treatment of mGluR 5 mediated disorders.
    Type: Application
    Filed: August 4, 2006
    Publication date: February 15, 2007
    Applicants: AstraZeneca AB, NPS PHARMACEUTICALS
    Inventors: Louise Edwards, Methvin Isaac, Abdelmalik Slassi, Guang-Ri Sun, Peter Dove, Erwan Arzel
  • Substituted piperazines as metabotropic glutamate receptor antagonists
    Publication number: 20070037820
    Abstract: The invention relates to compounds of formula I or pharmaceutically acceptable salts or solvates thereof: where Ar1, Ar2, Hy, L, R1, m and n are as defined in the description. The invention also includes pharmaceutical compositions and uses thereof, processes for making the compounds, as well as methods for the medical treatment of mGluR5-mediated disorders.
    Type: Application
    Filed: August 4, 2006
    Publication date: February 15, 2007
    Applicants: AstraZeneca AB, NPS PHARMACEUTICALS, INC.
    Inventors: Louise Edwards, Abdelmalik Slassi, Methvin Isaac, Donald McLeod
  • Bicyclic piperazines as metabotropic glutatmate receptor antagonists
    Publication number: 20070037816
    Abstract: The invention relates to compounds of formula I or pharmaceutically acceptable salts or solvates thereof: where Ar1, A, Hy, R1, m and n are as defined in the description. The invention also includes pharmaceutical compositions and uses of, and processes of making the compounds, as well as methods of medical treatment of mGluR5-mediated disorders.
    Type: Application
    Filed: August 4, 2006
    Publication date: February 15, 2007
    Applicants: AstraZeneca AB, NPS Pharmaceuticals
    Inventors: Louise Edwards, Methvin Isaac, Abdelmalik Slassi, Guang-Ri Sun, Tao Xin, Alexander Minidis, Peter Dove
  • Tricyclic benzimidazoles and their use as metabotropic glutamate receptor modulators
    Publication number: 20070032469
    Abstract: The invention provides for a compound of formula (I) or a pharmaceutically acceptable salt thereof: wherein R1, R2, R3, A, B, D, m, n, x, and y are defined as described in the specification. The invention additionally provides a pharmaceutically composition comprising the compound of formula I, together with a method of using the same to treat or prevent neurological and psychiatric disorders. The compounds are useful in therapy related to the treatment or prevention of mGluR2 receptor-mediated disorders.
    Type: Application
    Filed: July 21, 2006
    Publication date: February 8, 2007
    Applicants: AstraZeneca AB, NPS PHARMACEUTICALS
    Inventors: Methvin Isaac, Abdelmalik Slassi, Ian Egle, Fupeng Ma
  • Therapeutic compounds
    Publication number: 20070021606
    Abstract: The present invention provides novel compounds that function as potentiators of glutamate receptors, methods for their preparation, pharmaceutical compositions containing them, and methods of their use in therapy.
    Type: Application
    Filed: April 15, 2004
    Publication date: January 25, 2007
    Inventors: Ian Egle, Jennifer Frey, Methvin Isaac, Abdelmalik Slassi, Guang-Ri Sun, Jonathan Field
  • Acetylinic piperazine compounds and their use as metabotropic glutamate receptor antagonists
    Publication number: 20060235024
    Abstract: The present invention relates to new acetylinic piperazine compounds of formula I, their pharmaceutically acceptable salts, and hydrates: wherein R1, R2, R3, R4, M, and n are as defined in the description. The invention also relates to processes for the preparation of the compounds and to new intermediates employed in the preparation, pharmaceutical compositions containing the compounds, and to the use of the compounds in therapy.
    Type: Application
    Filed: August 17, 2005
    Publication date: October 19, 2006
    Inventors: Chris Bryan, Methvin Isaac, Tomislav Stefanac, Abdelmalik Slassi, Louise Edwards
  • Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
    Patent number: 7112595
    Abstract: The present invention provides compounds and pharmaceutical compositions that act as antagonists at metabotropic glutamate receptors, and that are useful for treating neurological diseases and disorders. Methods of preparing the compounds also are disclosed.
    Type: Grant
    Filed: November 3, 2003
    Date of Patent: September 26, 2006
    Assignees: NPS Pharmaceuticals, Inc., Astrazeneca AB
    Inventors: Bradford Van Wagenen, Thomas M. Stormann, Scott T Moe, Susan M Sheehan, Donald McLeod, Daryl L Smith, Methvin Isaac, Abdelmalik Slassi, Ian Egle, Louise Edwards, Tomislav Stefanac, Tao Xin, Jalaj Arora, William Michne
  • Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
    Publication number: 20060189661
    Abstract: The present invention provides compounds and pharmaceutical compositions that act as antagonists at metabotropic glutamate receptors, and that are useful for treating neurological diseases and disorders. Methods of preparing the compounds also are disclosed.
    Type: Application
    Filed: April 6, 2006
    Publication date: August 24, 2006
    Inventors: Bradford Wagenen, Thomas Stormann, Scott Moe, Susan Sheehan, Donald McLeod, Daryl Smith, Methvin Isaac, Abdelmalik Slassi, Ian Egle, Louise Edwards, Tomislav Stefanac, Tao Xin, Jalaj Arora, William Michne
  • Compounds
    Patent number: 7074809
    Abstract: The present invention relates to new compounds of formula I, wherein P, Q, X1, X2, X3, X4, X5, R, R1, R2, R3, R4, R5, G, M1, M2, M3, m and n, are defined as in formula I, a process for their preparation and new intermediates prepared therein, pharmaceutical formulations containing said compounds and to the use of said compounds in therapy.
    Type: Grant
    Filed: August 8, 2003
    Date of Patent: July 11, 2006
    Assignees: AstraZeneca AB, NPS Pharmaceuticals
    Inventors: Jalaj Arora, Louise Edwards, Methvin Isaac, Abdelmalik Slassi, Tomislav Stefanac, David Wensbo, Tao Xin
  • Compounds
    Publication number: 20060122397
    Abstract: The present invention relates to new compounds of formula I, a process for their preparation and new intermediates prepared therein, pharmaceutical formulations containing said compounds and to the use of said compounds in therapy.
    Type: Application
    Filed: November 14, 2005
    Publication date: June 8, 2006
    Applicants: AstraZeneca AB, NPS Pharmaceutical
    Inventors: Jalaj Arora, Louise Edwards, Methvin Isaac, Donald McLeod, Abdelmalik Slassi, Tomislav Stefanac, Thomas Stormann, David Wensbo, Tao Xin, Helena Gyback, Martin Johansson, Annika Kers, John Malmberg, Alexander Minidis, Karin Oscarsson, Mangus Waldman, Ulrika Yngve, Christoffer Osterwall
  • New compounds
    Publication number: 20060063772
    Abstract: The present invention relates to new compounds of formula I, wherein P, Q, X1, X2, X3, X4, X4, R, R1, R2, R3, R4, R5, R6, R7, m, n, o, p and q are defined as in any one of claims 1 to 12, a process for their preparation and new intermediates prepared therein, pharmaceutical formulations containing said compounds and to the use of said compounds in therapy.
    Type: Application
    Filed: November 10, 2005
    Publication date: March 23, 2006
    Inventors: Jalaj Arora, Louise Edwards, Methvin Isaac, Donald McLeod, Abdelmalik Slassi, Tomislav Stefanac, Thomas Stormann, David Wensbo, Tao Xin, Annika Kers, Johan Malmberg, Karin Oscarsson
  • Poly-heterocyclic compounds and their use as metabotropic glutamate receptor antagonists
    Publication number: 20060025414
    Abstract: The present invention relates to new compounds of formula I, wherein P, Q, X1, X2, X3, X4 X5, X6, R1, R2, R3, m, n, and p are as defined as in formula I, or salts, or hydrates thereof, processes for their preparation and new intermediates used in the preparation thereof, pharmaceutical compositions containing said compounds and to the use of said compounds in therapy.
    Type: Application
    Filed: February 18, 2005
    Publication date: February 2, 2006
    Inventors: Jalaj Arora, Louise Edwards, Methvin Isaac, Annika Kers, Karin Staaf, Abdelmalik Slassi, Tomislav Stefanac, David Wensbo, Tao Xin, Bjorn Holm
  • Triazole compounds and their use as metabotropic glutamate receptor antagonists
    Publication number: 20060019997
    Abstract: The present invention relates to new compounds of formula I, wherein P, Q, X1, X2, X3, X4 X7, X8, R1, R2, R3, m, n, and p are as defined as in formula I, or salts, or hydrates thereof, processes for their preparation and new intermediates used in the preparation thereof, pharmaceutical compositions containing said compounds and to the use of said compounds in therapy.
    Type: Application
    Filed: February 18, 2005
    Publication date: January 26, 2006
    Inventors: Louise Edwards, Methvin Isaac, Martin Johansson, Johan Malmberg, Alexander Minidis, Karin Staaf, Abdelmalik Slassi, David Wensbo, Tomislav Stefanac, Tao Xin