Patents by Inventor Meyer B. Jackson

Meyer B. Jackson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Engineered botulinum neurotoxin C1 with selective substrate specificity
    Patent number: 8853360
    Abstract: An isolated polypeptide comprising a botulinum neurotoxin C1 light chain having a modified amino acid sequence relative to the sequence of a wild-type botulinum neurotoxin C1 light chain is disclosed. The modified botulinum neurotoxin C1 light chain is capable of selectively cleaving syntaxin protein, but has substantially reduced or no activity against SNAP-25 as compared to wild type botulinum neurotoxin C1 light chain, and is thus useful as a research tool and in medical treatment.
    Type: Grant
    Filed: June 23, 2011
    Date of Patent: October 7, 2014
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Meyer B. Jackson, Dongsheng Wang
  • ENGINEERED BOTULINUM NEUROTOXIN C1 WITH SELECTIVE SUBSTRATE SPECIFICITY
    Publication number: 20110318385
    Abstract: An isolated polypeptide comprising a botulinum neurotoxin C1 light chain having a modified amino acid sequence relative to the sequence of a wild-type botulinum neurotoxin C1 light chain is disclosed. The modified botulinum neurotoxin C1 light chain is capable of selectively cleaving syntaxin protein, but has substantially reduced or no activity against SNAP-25 as compared to wild type botulinum neurotoxin C1 light chain, and is thus useful as a research tool and in medical treatment.
    Type: Application
    Filed: June 23, 2011
    Publication date: December 29, 2011
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Meyer B. Jackson, Dongsheng Wang
  • Drug and pesticide screening
    Patent number: 6008046
    Abstract: The present invention relates to methods and reagents for drug and pesticide screening. Screening methods are disclosed employing normal and mutant receptors, allowing for the testing of large numbers of potentially useful compounds.
    Type: Grant
    Filed: June 2, 1993
    Date of Patent: December 28, 1999
    Assignee: Ophidian Pharmaceuticals, Inc.
    Inventors: Richard H. Ffrench-Constant, Meyer B. Jackson
  • Method for regulating neuropeptide hormone secretion
    Patent number: 5763431
    Abstract: Methods are described for regulating neuropeptide secretion to alleviate premature labor, hypertension, fluid imbalance, and risk of heart disease using neuroactive steroids targeted for a newly-identified site of action in the nerve terminals of neurosecretory neurons.
    Type: Grant
    Filed: August 23, 1996
    Date of Patent: June 9, 1998
    Inventor: Meyer B. Jackson
  • Regulating neuropeptide hormone secretion
    Patent number: 5550120
    Abstract: Methods are described for regulating neuropeptide secretion to alleviate premature labor, hypertension, fluid imbalance, and risk of heart disease: using neuroactive steroids targeted for a newly-identified site of action in the nerve terminals of neurosecretory neurons. The steroids 17 betaestradiol and dehydroepiandrosterone increase the release of neuropeptide hormones such as oxytocin and vasopressin. Pregnalone derivatives decrease the release of the same hormones.
    Type: Grant
    Filed: April 3, 1995
    Date of Patent: August 27, 1996
    Inventor: Meyer B. Jackson