Patents by Inventor Meyer Sletzinger

Meyer Sletzinger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cephalosporin intermediates
    Patent number: 4324890
    Abstract: Process and intermediate products useful in the preparation of cephalosporin compounds having a substituent at the 7-position in place of hydrogen are provided. The new cephalosporin compounds are active against various gram-negative and gram-positive organisms.
    Type: Grant
    Filed: April 30, 1980
    Date of Patent: April 13, 1982
    Assignee: Merck & Co., Inc.
    Inventors: Burton G. Christensen, Sandor Karady, Lovji D. Cama, Meyer Sletzinger
  • Process for preparing N-protected 2-aminoethanethiol
    Patent number: 4299974
    Abstract: Disclosed is a process for preparing N-protected 2-aminoethanethiol which proceeds via the silyl covered sulfur intermediate: ##STR1## wherein R.sup.1 is triorganosilyl and R.sup.2 is a readily removable N-protecting group.
    Type: Grant
    Filed: June 16, 1980
    Date of Patent: November 10, 1981
    Assignee: Merck & Co., Inc.
    Inventors: Thomas M. H. Liu, Ichiro Shinkai, Meyer Sletzinger
  • 7-.alpha.-Methoxy cephalosporins
    Patent number: 4297488
    Abstract: Process and intermediate products useful in the preparation of cephalosporin compounds having a substituent at the 7-position in place of hydrogen are provided. The new cephalosporin compounds are active against various gram-negative and gram-positive organisms.
    Type: Grant
    Filed: June 2, 1971
    Date of Patent: October 27, 1981
    Assignee: Merck & Co., Inc.
    Inventors: Burton G. Christensen, Lovji D. Cama, Sandor Karady, Meyer Sletzinger
  • Process for the preparation of N-protected N-formimidoyl 2-aminoethanethiol
    Patent number: 4292436
    Abstract: Disclosed is 2 and a process for its preparation: ##STR1## It is useful in the synthesis of N-formimidoyl thienamycin; R.sup.2 is hydrogen or a protecting group.
    Type: Grant
    Filed: June 25, 1980
    Date of Patent: September 29, 1981
    Assignee: Merck & Co., Inc.
    Inventors: Thomas M. H. Liu, Robert A. Reamer, Ichiro Shinkai, Meyer Sletzinger
  • Synthesis of thienamycin via (3SR, 4RS)-3-((RS)-1-acyloxyethyl)-2-oxo-4-azetidineacetate
    Patent number: 4287123
    Abstract: Disclosed is a process for the stereocontrolled total synthesis of thienamycin, which synthesis proceeds via intermediate II: ##STR1## wherein R is a readily removable carboxyl protecting group; and ##STR2## is a readily removable acyl group.
    Type: Grant
    Filed: January 14, 1980
    Date of Patent: September 1, 1981
    Assignee: Merck & Co., Inc.
    Inventors: Thomas M. H. Liu, David G. Melillo, Kenneth M. Ryan, Ichiro Shinkai, Meyer Sletzinger
  • Synthesis of thienamycin via esters of (3SR, 4RS)-3-[(SR)-1-hydroxyethyl]-.beta.,2-dioxo-4-azetidinebutanoic acid
    Patent number: 4282148
    Abstract: Disclosed is a process for the stereocontrolled total synthesis of thienamycin, which synthesis proceeds via intermediate II: ##STR1## wherein R.sup.3 is a readily removable carboxyl protecting group.
    Type: Grant
    Filed: January 14, 1980
    Date of Patent: August 4, 1981
    Assignee: Merck & Co., Inc.
    Inventors: Thomas M. H. Liu, David G. Melillo, Kenneth M. Ryan, Ichiro Shinkai, Meyer Sletzinger
  • Synthesis of racemic 3-fluoro-alanine and its salts
    Patent number: 4149012
    Abstract: The racemate of 3-fluoro-alanine, and salts thereof, are prepared by reductive amination of 3-fluoro-pyruvic acid, its hydrate, or salts thereof, via the intermediate 2-imino-3-fluoro propionic acid salt, using alkali metal borohydrides as reducing agents. The racemates thus obtained are valuable in the production of 3-fluoro-D-alanine and its pharmacologically acceptable salts, and derivatives thereof, which are potent antibacterial agents.
    Type: Grant
    Filed: October 7, 1977
    Date of Patent: April 10, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Ulf-H. Dolling, Edward J. J. Grabowski, Erwin F. Schoenewaldt, Meyer Sletzinger
  • 7-Diacylimido cephalosporins
    Patent number: 4107432
    Abstract: New 7-diacylimido cephalosporins are produced by reacting 7-acylamido cephalosporins with an acylating agent in the presence of a silyl reagent. The 7-diacylimido cephalosporins are cleaved to produce cephalosporins containing a different acylamido moiety. Thus, the aminoadipoyl group of cephalosporins produced by fermentation is replaced by a different acyl group by the process of the present invention. The cephalosporins produced are antibiotics having enhanced activity against gram-negative and gram-positive pathogens.
    Type: Grant
    Filed: April 25, 1977
    Date of Patent: August 15, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Burton G. Christensen, Lovji D. Cama, Sandor Karady, Meyer Sletzinger
  • 7-Diacyl cephalosporins
    Patent number: 4058661
    Abstract: New 7-diacylimido cephalosporins are produced by reacting 7-acylamido cephalosporins with an acylating agent in the presence of a silyl reagent. The 7-diacylimido cephalosporins are cleaved to produce cephalosporins containing a different acylamido moiety. Thus, the aminoadipoyl group of cephalosporins produced by fermentation is replaced by a different acyl group by the process of the present invention. The cephalosporins produced are antibiotics having enhanced activity against gram-negative and gram-positive pathogens.
    Type: Grant
    Filed: April 7, 1975
    Date of Patent: November 15, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Lovji D. Cama, Burton G. Christensen, Sandor Karady, Meyer Sletzinger
  • Process for the production of 7-acylamidocephalosporins
    Patent number: 4014873
    Abstract: New 7-diacylimido cephalosporins are produced by reacting 7-acylamido cephalosporins with an acylating agent in the presence of a silyl reagent. The 7-diacylimido cephalosporins are cleaved to produce cephalosporins containing a different acylamido moiety. Thus, the aminoadipoyl group of cephalosporins produced by fermentation is replaced by a different acyl group by the process of the present invention. The cephalosporins produced are antibiotics having enhanced activity against gram-negative and gram-positive pathogens.
    Type: Grant
    Filed: November 29, 1974
    Date of Patent: March 29, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Burton G. Christensen, Lovji D. Cama, Meyer Sletzinger, Sandor Karady
  • 3-Substituted methyl-7-acylamino-7-methoxy-2-cephem-4-carboxylic acid and its esters
    Patent number: 3987040
    Abstract: Process for preparing an ester of 3-substituted methyl-7-acylamido-7-methoxy(or hydrogen)-2-cephem-4-carboxylic acid and its corresponding sulfoxide by treating an ester of 3-carbamoyloxymethyl(or 3-lower alkanoyloxymethyl)-7-acylamido-7-methoxy(or hydrogen)-2-cephem-4-carboxyli c acid with a hydrohalic acid or another compound containing an active hydrogen and then with an oxidizing agent. The products obtained are useful as intermediates in the preparation of antibiotics.
    Type: Grant
    Filed: December 5, 1974
    Date of Patent: October 19, 1976
    Assignee: Merck & Co., Inc.
    Inventors: Theresa Y. Cheng, Sandor Karady, Seemon H. Pines, Meyer Sletzinger
  • Process for preparing (1-oxo-2-cyclopentyl-2-methyl-6,7-dichloro-5-indanyloxy)acetic acid
    Patent number: 3981911
    Abstract: A process for preparing (1-oxo-2-cyclopentyl-2-methyl-6,7-dichloro-5-indanyloxy)acetic acid comprising reacting 5-cyclopentyl-5-methyl-2-cyclopentenone with a 4-carbon conjugated (open or cyclic) diene bearing vicinal chlorines adjacent to an ether group; aromatizing the resulting adduct to yield the desired indanone.
    Type: Grant
    Filed: February 15, 1974
    Date of Patent: September 21, 1976
    Assignee: Merck & Co., Inc.
    Inventors: Meyer Sletzinger, George G. Hazen
  • Process for the preparation of chloromethyl methyl ether
    Patent number: 3972947
    Abstract: Single vessel, closed system, anhydrous, process for preparing high purity chloromethyl methyl ether comprising reacting methylal with hydrogen chloride; wherein said hydrogen chloride is generated, in situ, by contacting methanol, a reaction intermediate, with an acid chloride.
    Type: Grant
    Filed: July 15, 1975
    Date of Patent: August 3, 1976
    Assignee: Merck & Co., Inc.
    Inventors: Leonard M. Weinstock, Sandor Karady, Meyer Sletzinger
  • Synthesis of racemic 2-deutero-3-fluoro-alanine and its salts
    Patent number: 3972921
    Abstract: The racemates of 2-deutero-3-fluoro-alanine and its salts are prepared by reductive amination of 3-fluoro-pyruvic acid, its hydrate or salts thereof, via the intermediate 2-imino-3-fluoro propionic acid salt, using alkali metal borodeuterides as reducing agents. The racemates thus obtained are valuable in the production of the corresponding 2-deutero-3-fluoro-D-alanine, and its pharmacologically acceptable salts, and derivatives thereof, which are potent antibacterial agents.
    Type: Grant
    Filed: November 8, 1974
    Date of Patent: August 3, 1976
    Assignee: Merck & Co., Inc.
    Inventors: Ulf-H. Dolling, Edward J. J. Grabowski, Erwin F. Schoenewaldt, Meyer Sletzinger