Abstract: The present invention provides methods for the use of compounds as depicted by structure I, pharmaceutical compositions containing the same, and methods for the prophylaxis, management and treatment of metabolic diseases and diseases modulated by MCD inhibition. The compounds disclosed in this invention are useful for the prophylaxis, management and treatment of diseases involving in malonyl-CoA regulated glucose/fatty acid metabolism pathway. In particular, these compounds and pharmaceutical composition containing the same are indicated in the prophylaxis, management and treatment of cardiovascular diseases, diabetes, cancer and obesity.

Abstract: Compounds having utility as GnRH receptor antagonists and for treatment of a variety of sex-hormone related conditions in both men and women. Such compounds have the following structure (I): (I) wherein R1a, R1b, R1c, R2a, R2b, R3, R4, R5, R6, R7, n and X are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of structure (I) in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.

Abstract: The present invention relates to methods for the prophylaxis, management and treatment of certain diseases modulated by the inhibition of the enzyme malonyl-coenzyme A decarboxylase (malonyl-CoA decarboxylase, MCD) by the administration of a composition containing as an active ingredient a compound according to Formula I. In particular, the invention relates to methods for the prophylaxis, management and treatment of cardiovascular diseases, diabetes, acidosis, cancers, and obesity through the administration of a compound which inhibits malonyl-coenzyme A decarboxylase activity.

Abstract: The present invention relates to novel compounds (I), their prodrugs, and the pharmaceutically acceptable salts as well as pharmaceutical compositions containing such compounds useful in treating certain metabolic diseases and diseases modulated by the inhibition of the enzyme malonyl-coenzyme A decarboxylase (malonyl-CoA decarboxylase, MCD). In particular, the invention relates to compounds and compositions and the methods for the prophylaxis, management and treatment of cardiovascular diseases, diabetes, acidosis, cancers, and obesity through the inhibition of malonyl-coenzyme A decarboxylase.

Abstract: The present invention relates to novel compounds (I), their prodrugs, and the pharmaceutically acceptable salts as well as pharmaceutical compositions containing such compounds useful in treating certain metabolic diseases and diseases modulated by the inhibition of the enzyme malonyl-coenzyme A decarboxylase (malonyl-CoA decarboxylase, MCD). In particular, the invention relates to compounds and compositions and the methods for the prophylaxis, management and treatment of cardiovascular diseases, diabetes, acidosis, cancers, and obesity through the inhibition of malonyl-coenzyme A decarboxylase.

Abstract: A display and a method of coupling at least one circuit board to a panel of the display. The display comprises a frame mounted on the display panel. The frame comprises a first body and a second body perpendicularly connected to the first body. The circuit board is coupled to the first body via the second body is not covered by the frame. At least one shield element is coupled to the frame to cover the circuit board.

Abstract: A foodstuff is produced through extracting healthful and medicinal compositions contained in peanut stems. The food stuff may be in the form of liquid, cream, powder, tablet or capsule for users to drink, eat, or swallow conveniently. The foodstuff produced with extract of peanut stem contains not only nutrient that is helpful in health, but also special medicinal compositions useful in regulating blood sugar and alleviating or even curing pains of patients having uric acid problems, and is therefore suitable for drinking or eating on a long-term basis.

Abstract: A display and a method of coupling a circuit board to a panel of the display. A frame is secured to the panel, and the circuit board is coupled to the frame in such a manner that a part of the fire is positioned between the circuit board and the panel. A shield element is secured to the frame to shield the circuit board.

Abstract: Novel compounds composition capable of inhibiting TNF? and having antiimmunoinflammatory and autoimmune properties useful in a pharmaceutical composition, such as for a drug containing this as an active ingredient; and a therapeutic method with the use of these novel compounds.

Abstract: Novel compounds composition capable of inhibiting TNF? and having anti immunoinflammatory and autoimmune properties useful in a pharmaceutical composition, such as for a drug containing this as an active ingredient; and a therapeutic method with the use of these novel compounds.

Abstract: A novel solution phase and solid phase synthesis of 4-N-acyl-?5-2-oxopiperazine (I) is described via a Ugi four-component condensation of an acid, an ketone or aldehyde, a protected ?-aminoaldehyde or ?-aminoketone and an isocyanide followed by an N-acyliminium ion cyclization facilitated by an acid, which also cleaves the product from the polymer when the reaction is conducted in the solid phase.

Abstract: The present invention provides methods for the use of compounds as depicted by structure I, pharmaceutical compositions containing the same, and methods for the prophylaxis, management and treatment of metabolic diseases and diseases modulated by MCD inhibition. The compounds disclosed in this invention are useful for the prophylaxis, management and treatment of diseases involving in malonyl-CoA regulated glucose/fatty acid metabolism pathway. In particular, these compounds and pharmaceutical composition containing the same are indicated in the prophylaxis, management and treatment of cardiovascular diseases, diabetes, cancer and obesity.

Abstract: Novel compounds composition capable of inhibiting TNF? and having antiimmunoinflammatory and autoimmune properties useful in a pharmaceutical composition, such as for a drug containing this as an active ingredient; and a therapeutic method with the use of these novel compounds.

Abstract: The present invention relates to methods for the prophylaxis, management and treatment of certain diseases modulated by the inhibition of the enzyme malonyl-coenzyme A decarboxylase (malonyl-CoA decarboxylase, MCD) by the administration of a composition containing as an active ingredient a compound according to Formula I. In particular, the invention relates to methods for the prophylaxis, management and treatment of cardiovascular diseases, diabetes, acidosis, cancers, and obesity through the administration of a compound which inhibits malonyl-coenzyme A decarboxylase activity. The present invention also includes within its scope the novel process for the preparation of certain compounds.

Abstract: This invention provides a process for preparing an N-substituted 2-sulfanylimidazole compound of the formula (I) by reacting an isothiocyanate of the formula R1NCS with an &agr;-aminocarbonyl compound of the formula NH2CHR4C(OP)2R3 and an alkyl halide or an activated aryl halide of the formula R2X in a solvent, alternatively, by reacting an isothiocyanate of the formula R1NCS with an &agr;-aminocarbonyl compound of the formula NH2CHR4C(OP)2R3 before adding an alkyl halide of the formula R2X, wherein R1 and R2 independently represent alkyl, heterocyclyl, aryl, or heteroaryl groups; R3 and R4 independently represent hydrogen, alkyl, heterocyclyl, aryl or heteroaryl or may form a non-aromatic ring; P represents a protecting group of a carbonyl group.

Abstract: The present invention relates to novel compounds (I), their prodrugs, and the pharmaceutically acceptable salts as well as pharmaceutical compositions containing such compounds useful in treating certain metabolic diseases and diseases modulated by the inhibition of the enzyme malonyl-coenzyme A decarboxylase (malonyl-CoA decarboxylase, MCD). In particular, the invention relates to compounds and compositions and the methods for the prophylaxis, management and treatment of cardiovascular diseases, diabetes, acidosis, cancers, and obesity through the inhibition of malonyl-coenzyme A decarboxylase.

Abstract: The present invention relates to novel compounds (I), their prodrugs, and the pharmaceutically acceptable salts as well as pharmaceutical compositions containing such compounds useful in treating certain metabolic diseases and diseases modulated by the inhibition of the enzyme malonyl-coenzyme A decarboxylase (malonyl-CoA decarboxylase, MCD). In particular, the invention relates to compounds and compositions and the methods for the prophylaxis, management and treatment of cardiovascular diseases, diabetes, acidosis, cancers, and obesity through the inhibition of malonyl-coenzyme A decarboxylase.

Abstract: A convenient one step synthesis of N-substituted 2-sulfanylimidazole from an isothiocyanate, an &agr;-aminocarbonyl compound and an alkyl halide or an activated aryl halide is described. Reaction of an isothiocyanate with an &agr;-aminocarbonyl compound affords a thiourea acetal intermediate, which without isolation or purification affords the desired N-substituted 2-sulfanylimidazole upon treatment with an alkyl halide or an activated aryl halide.

Abstract: A rotating mechanism for an LCD monitor having a monitor and a supporting structure. The rotating mechanism comprises a protruding sleeve, a supporting body, a shaft sleeve, a sleeve, a first screwing element and a second screwing element. The protruding sleeve has a fitting hole and is disposed on the back of the monitor. The supporting body has a bending element. The shaft sleeve is fitted between the protruding sleeve and the bending element of the supporting body. The sleeve is fitted in the fitting hole of the protruding sleeve. The first screwing element is threaded into one end of the shaft sleeve from the sleeve. The second screwing element is threaded into the other end of the shaft sleeve from the bending element. Thus, the tightness of the rotating mechanism of the invention can be adjusted by way of the first screwing element.

Abstract: A rotating mechanism for LCD monitor having a monitor and a supporting structure. The rotating mechanism comprises a protruding sleeve, a supporting body, a shaft sleeve, a sleeve, a first screwing element and a second screwing element. The protruding sleeve has a fitting hole and is disposed on the back of the monitor. The supporting body has a bending element. The shaft sleeve is fitted between the protruding sleeve and the bending element of the supporting body. The sleeve is fitted in the fitting hole of the protruding sleeve. The first screwing element is threaded into one end of the shaft sleeve from the sleeve. The second screwing element is threaded into the other end of the shaft sleeve from the bending element. Thus, the tightness of the rotating mechanism of the invention can be adjusted by way of the first screwing element.