Patents by Inventor Mi Ji Lee
Mi Ji Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220202996Abstract: Provided is a medical implant including: an implant base having a surface made of a silicon material; a linker having one end attached onto the surface of the implant base; and a cytokine bound to another end of the linker. By inducing the secretion of anti-inflammatory cytokines, a capsular contracture, which is one of the complications that may occur after transplantation of the patient's breast implant, may occur less.Type: ApplicationFiled: December 11, 2019Publication date: June 30, 2022Applicants: SEOUL NATIONAL UNIVERSITY HOSPITAL, SOOKMYUNG WOMEN'S UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATIONInventors: Chan Yeong HEO, Sun Young NAM, Mi Ji LEE, Byung Ho SHIN, Dong Sik SHIN, Seong Soo KIM
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Patent number: 11040110Abstract: Disclosed is a protein complex, comprising a physiologically active polypeptide, a dimeric protein and a non-peptidyl polymer having three functional ends (3-arm), with the linkage of both the physiologically active polypeptide and the dimeric protein to the 3-arm non-peptidyl polymer via respective covalent bonds. The protein complex guarantees the long acting activity and biostability of a physiologically active polypeptide. Having the ability to maintain the bioactivity of physiologically active polypeptides or peptides highly and to significantly improve the serum half life of the polypeptides or peptides, the protein complex can be applied to the development of sustained release formulations of various physiologically active polypeptide drugs. Also, it utilizes raw materials including the physiologically active polypeptides without significant loss, thereby increasing the production yield. Further, it can be easily purified.Type: GrantFiled: August 7, 2018Date of Patent: June 22, 2021Assignee: HANMI SCIENCE CO., LTD.Inventors: Dae Hae Song, Jae Hee Shin, Mi Ji Lee, Sung Hee Hong, Se Chang Kwon, Gwan Sun Lee
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Publication number: 20180360983Abstract: Disclosed is a protein complex, comprising a physiologically active polypeptide, a dimeric protein and a non-peptidyl polymer having three functional ends (3-arm), with the linkage of both the physiologically active polypeptide and the dimeric protein to the 3-arm non-peptidyl polymer via respective covalent bonds. The protein complex guarantees the long acting activity and biostability of a physiologically active polypeptide. Having the ability to maintain the bioactivity of physiologically active polypeptides or peptides highly and to significantly improve the serum half life of the polypeptides or peptides, the protein complex can be applied to the development of sustained release formulations of various physiologically active polypeptide drugs. Also, it utilizes raw materials including the physiologically active polypeptides without significant loss, thereby increasing the production yield. Further, it can be easily purified.Type: ApplicationFiled: August 7, 2018Publication date: December 20, 2018Applicant: HANMI SCIENCE CO., LTD.Inventors: Dae Hae SONG, Jae Hee SHIN, Mi Ji LEE, Sung Hee HONG, Se Chang KWON, Gwan Sun LEE
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Patent number: 10071171Abstract: Disclosed is a protein complex, comprising a physiologically active polypeptide, a dimeric protein and a non-peptidyl polymer having three functional ends (3-arm), with the linkage of both the physiologically active polypeptide and the dimeric protein to the 3-arm non-peptidyl polymer via respective covalent bonds. The protein complex guarantees the long acting activity and biostability of a physiologically active polypeptide. Having the ability to maintain the bioactivity of physiologically active polypeptides or peptides highly and to significantly improve the serum half life of the polypeptides or peptides, the protein complex can be applied to the development of sustained release formulations of various physiologically active polypeptide drugs. Also, it utilizes raw materials including the physiologically active polypeptides without significant loss, thereby increasing the production yield. Further, it can be easily purified.Type: GrantFiled: October 2, 2015Date of Patent: September 11, 2018Assignee: HANMI SCIENCE CO., LTD.Inventors: Dae Hae Song, Jae Hee Shin, Mi Ji Lee, Sung Hee Hong, Se Chang Kwon, Gwan Sun Lee
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Patent number: 9867777Abstract: Disclosed is a liquid formulation which allows long-acting G-CSF conjugates, that have improved in vivo duration and stability, to be stable when stored for a long period of time. It comprises a stabilizer composition characterized by buffer and mannitol. Being free of human serum albumin and other potential factors harmful to the body, the liquid formulation is free of concerns about viral infections and guarantees excellent storage stability to long-acting G-CSF conjugates.Type: GrantFiled: January 18, 2011Date of Patent: January 16, 2018Assignee: Hanmi Science Co., Ltd.Inventors: Mi Ji Lee, Jae Min Lee, Byung Sun Lee, Sung Min Bae, Se Chang Kwon
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Patent number: 9636420Abstract: Disclosed is a protein complex, comprising a physiologically active polypeptide, a dimeric protein and a non-peptidyl polymer having three functional ends (3-arm), with the linkage of both the physiologically active polypeptide and the dimeric protein to the 3-arm non-peptidyl polymer via respective covalent bonds. The protein complex guarantees the long acting activity and biostability of a physiologically active polypeptide. Having the ability to maintain the bioactivity of physiologically active polypeptides or peptides highly and to significantly improve the serum half life of the polypeptides or peptides, the protein complex can be applied to the development of sustained release formulations of various physiologically active polypeptide drugs. Also, it utilizes raw materials including the physiologically active polypeptides without significant loss, thereby increasing the production yield. Further, it can be easily purified.Type: GrantFiled: July 23, 2009Date of Patent: May 2, 2017Assignee: HANMI SCIENCE CO., LTD.Inventors: Dae Hae Song, Jae Hee Shin, Mi Ji Lee, Sung Hee Hong, Se Chang Kwon, Gwan Sun Lee
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Publication number: 20160051696Abstract: Disclosed is a protein complex, comprising a physiologically active polypeptide, a dimeric protein and a non-peptidyl polymer having three functional ends (3-arm), with the linkage of both the physiologically active polypeptide and the dimeric protein to the 3-arm non-peptidyl polymer via respective covalent bonds. The protein complex guarantees the long acting activity and biostability of a physiologically active polypeptide. Having the ability to maintain the bioactivity of physiologically active polypeptides or peptides highly and to significantly improve the serum half life of the polypeptides or peptides, the protein complex can be applied to the development of sustained release formulations of various physiologically active polypeptide drugs. Also, it utilizes raw materials including the physiologically active polypeptides without significant loss, thereby increasing the production yield. Further, it can be easily purified.Type: ApplicationFiled: October 2, 2015Publication date: February 25, 2016Applicant: HANMI SCIENCE CO., LTD.Inventors: Dae Hae SONG, Jae Hee SHIN, Mi Ji LEE, Sung Hee HONG, Se Chang KWON, Gwan Sun LEE
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Patent number: 9186415Abstract: The present invention relates to a long-acting human follicle-stimulating hormone formulation having improved in vivo duration and stability, comprising a human follicle-stimulating hormone conjugate that is prepared by covalently linking human follicle-stimulating hormone with an immunoglobulin Fc region via a non-peptidyl polymer, and a preparation method thereof. The long-acting human follicle-stimulating hormone formulation of the present invention maintains in vivo activity of human follicle-stimulating hormone at a relatively high level and remarkably increases the serum half-life thereof.Type: GrantFiled: April 4, 2011Date of Patent: November 17, 2015Assignee: HANMI SCIENCE CO., LTDInventors: Chang Hwan Kim, Sung Kap Hong, Byung Sun Lee, Soo Young Kwak, Mi Ji Lee, In Young Choi, Se Chang Kwon
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Patent number: 9154674Abstract: There is provided a camera module including: a lens barrel including at least one lens disposed on an optical axis; a housing having the lens barrel disposed therein; a circuit board disposed below the housing; and a shield-can coupled to the housing and enclosing an outer surface of the housing, wherein the circuit board is provided with a ground pad, and a contact surface of the shield-can contacting the ground pad is formed to have a convex-concave shape.Type: GrantFiled: September 18, 2013Date of Patent: October 6, 2015Assignee: Samsung Electro-Mechanics Co., Ltd.Inventor: Mi Ji Lee
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Publication number: 20150015778Abstract: There is provided a camera module including: a lens barrel including at least one lens disposed on an optical axis; a housing having the lens barrel disposed therein; a circuit board disposed below the housing; and a shield-can coupled to the housing and enclosing an outer surface of the housing, wherein the circuit board is provided with a ground pad, and a contact surface of the shield-can contacting the ground pad is formed to have a convex-concave shape.Type: ApplicationFiled: September 18, 2013Publication date: January 15, 2015Applicant: SAMSUNG ELECTRO-MECHANICS CO., LTD.Inventor: Mi Ji Lee
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Publication number: 20130022626Abstract: The present invention relates to a long-acting human follicle-stimulating hormone formulation having improved in vivo duration and stability, comprising a human follicle-stimulating hormone conjugate that is prepared by covalently linking human follicle-stimulating hormone with an immunoglobulin Fc region via a non-peptidyl polymer, and a preparation method thereof. The long-acting human follicle-stimulating hormone formulation of the present invention maintains in vivo activity of human follicle-stimulating hormone at a relatively high level and remarkably increases the serum half-life thereof.Type: ApplicationFiled: April 4, 2011Publication date: January 24, 2013Applicant: HANMI SCIENCE CO., LTD.Inventors: Chang Hwan Kim, Sung Kap Hong, Byung Sun Lee, Soo Young Kwak, Mi Ji Lee, In Young Choi, Se Chang Kwon
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Publication number: 20120294829Abstract: Disclosed is a liquid formulation which allows long-acting G-CSF conjugates, that have improved in vivo duration and stability, to be stable when stored for a long period of time. It comprises a stabilizer composition characterized by buffer and mannitol. Being free of human serum albumin and other potential factors harmful to the body, the liquid formulation is free of concerns about viral infections and guarantees excellent storage stability to long-acting G-CSF conjugates.Type: ApplicationFiled: January 18, 2011Publication date: November 22, 2012Applicant: HANMI SCIENCE CO., LTDInventors: Mi Ji Lee, Jae Min Lee, Byung Sun Lee, Sung Min Bae, Se Chang Kwon
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Publication number: 20110200623Abstract: Disclosed is a protein complex, comprising a physiologically active polypeptide, a dimeric protein and a non-peptidyl polymer having three functional ends (3-arm), with the linkage of both the physiologically active polypeptide and the dimeric protein to the 3-arm non-peptidyl polymer via respective covalent bonds. The protein complex guarantees the long acting activity and biostability of a physiologically active polypeptide. Having the ability to maintain the bioactivity of physiologically active polypeptides or peptides highly and to significantly improve the serum half life of the polypeptides or peptides, the protein complex can be applied to the development of sustained release formulations of various physiologically active polypeptide drugs. Also, it utilizes raw materials including the physiologically active polypeptides without significant loss, thereby increasing the production yield. Further, it can be easily purified.Type: ApplicationFiled: July 23, 2009Publication date: August 18, 2011Applicant: HANMI HOLDINGS CO., LTD.Inventors: Dae Hae Song, Jae Hee Shin, Mi Ji Lee, Sung Hee Hong, Se Chang Kwon, Gwan Sun Lee