Abstract: Provided are compositions and methods for treating cancers. It is demonstrated herein that mRNA molecules expressing an OX40 agonist protein and the IL-12 protein, when used in combination, achieve synergistic anti-tumor effects. Such synergistic effect is further enhanced when a soluble portion of the OX40 ligand (OX40L) is used as the agonist, instead of the full-length OX40L protein. The mRNA molecules are preferably synthetic and packaged in lipid nanoparticles for delivery. Whether delivered through intratumoral injections or injected by other routes, these mRNA molecules can effectively inhibit tumor growth at local as well as distal sites. In addition, with the increased anti-tumor efficacy, the combinations, in particular at a mass ratio of IL-12 to OX40L between 1:1 and 1:3, are associated with reduced toxicity. Interestingly, when GM-CSF is further added to the combination, the anti-tumor effects are further improved.

Abstract: This disclosure provides compositions and methods for treating cancers. The compositions include mRNA molecules encoding proteins useful for treating the cancers, such as IL-12, an OX40 agonist, and optionally along with FADD, MLKL or MLKL-4HB. The mRNA can include 5?UTR and 3?UTR sequences and 5?cap structures that improve the stability and/or therapeutic effects of these mRNA molecules.

Abstract: Provided are keratin BD-4, an encoding nucleic acid molecule thereof, an expression vector, a host cell, and a pharmaceutical composition containing the keratin. The keratin BD-4 can be used for preparing drugs having antipyretic and analgesic, antitussive and expectorant, and antiepileptic effects.

Abstract: A joint expression coding system based on static and dynamic expression images is disclosed, including an image preprocessing module, a dynamic expression image generation module, a dynamic weight image generation module, and a joint expression coding image generation module. A joint expression coding method based on the joint expression coding system is also disclosed. A static expression image and a dynamic expression image are combined into one image according to the coding method by adopting the joint expression coding system and method based on the static and dynamic expression images, whereby static expression information and dynamic expression information can be represented at the same time, thus improving the emotion recognition capability based on facial expressions.

Abstract: The present invention provides a keratin BD-3, a nucleic acid molecule encoding same, an expression vector, a host cell, a preparation method therefor, and a pharmaceutical composition contained the keratin BD-3. The keratin BD-3 can be used in the preparation of medicament for antipyretic, analgesic, antitussive, expectorant, anticonvulsant, antiepileptic, anti-hypertension, anti-inflammatory, and antiviral.

Abstract: A method and system for calculating emotional indicators based on pupil-wave are provided. The operation of calculating emotional indicators based on a pupil-wave may include the following operations. A pupil-wave is collected when a subject is in a calm state and set as a standard pupil-wave; Obtaining emotional indicators and corresponding emotions used to measure a mental state. The pupil-wave of the subject in each emotional state is collected and set as an emotional pupil-wave; According to the standard pupil-wave, a bandwidth and differential pupil-wave corresponding to each emotion are calculated; The standard, emotional, bandwidth and differential pupil-wave are input into a pre-trained deep convolutional neural network to obtain index values of emotional indicators.

Abstract: The present invention provides a keratin BD-6, a nucleic acid molecule encoding keratin BD-6, an expression vector containing the nucleic acid molecule, and a host cell containing the expression vector or the nucleic acid molecule integrated into genome, and preparation method of the keratin BD-6, and a pharmaceutical composition containing the keratin BD-6, and use of the above keratin BD-6, nucleic acid molecule, expression vector, host cell or pharmaceutical composition in the preparation of medicament for antipyretic, analgesic, antitussive, expectorant, anticonvulsant, antiepileptic, anti-hypertension, anti-inflammatory, and antiviral.

Abstract: Disclosed by the present invention are a swing motor and an electronic device, the swing motor comprising a seat; at least two movable members, comprising a first movable member and a second movable member arranged to be spaced apart, wherein the first movable member and the second movable member bear opposite electromagnetic thrusts; elastic support members that correspond one-to-one to the movable members, comprising a first elastic support member and a second elastic support member, wherein the first movable member is mounted onto the seat by means of the first elastic support member, and the second movable member is mounted onto the seat by means of the second elastic support member; further comprised is a twisting elastic member, one end of the twisting elastic member being connected to the first movable member or the second movable member, and the other end being connected to an executing member.

Abstract: Provided are keratin BD-4, an encoding nucleic acid molecule thereof, an expression vector, a host cell, and a pharmaceutical composition containing the keratin. The keratin BD-4 can be used for preparing drugs having antipyretic and analgesic, antitussive and expectorant, and antiepileptic effects.

Abstract: A system for preparing nanoscale zero-valent iron by reverse filtration in a non-open inert atmosphere is provided including an inert gas bottle, a gas monitoring and buffering device, a main reaction device configured as a three-necked flask, a condensing device including a condenser tube and a cold source, a waste liquid collecting device configured as a waste liquid collecting bottle, a liquid sealing device including a second liquid sealing bottle connected with the waste liquid collecting bottle through a first connecting-pipe, and an extraction pressure adjusting device including a third triple valve and a vacuum pump, all of which are connected by pipelines in sequence. Three necks of the three-necked flask are respectively provided with a first triple valve, a single-hole rubber plug pierced with a liquid-taking pipe, and a second triple valve. The second liquid sealing bottle is connected with the third triple valve.

Abstract: Disclosed by the present invention are a swing motor and an electronic device, the swing motor comprising a seat; at least two movable members, comprising a first movable member and a second movable member arranged to be spaced apart, wherein the first movable member and the second movable member bear opposite electromagnetic thrusts; elastic support members that correspond one-to-one to the movable members, comprising a first elastic support member and a second elastic support member, wherein the first movable member is mounted onto the seat by means of the first elastic support member, and the second movable member is mounted onto the seat by means of the second elastic support member; further comprised is a twisting elastic member, one end of the twisting elastic member being connected to the first movable member or the second movable member, and the other end being connected to an executing member.

Abstract: The present disclosure discloses a method and system for detecting visual attention. Embodiments of the present disclosure collect time sequences and corresponding pupil diameter sequences of each point of regard during visual attention process. Attention change curve is plotted according to the corresponding relationship between time sequences and pupil diameter sequences. The attention change curve is divided into four stages based on pre-setting time parameters and pupil diameter parameters. Numerical analysis of each stage is finished based on duration and rate of pupil change. Quantitative calculation of visual attention of each stage is realized, and the changing procedure of visual attention can be portrayed entirely, systematically and quantitatively.

Abstract: A normalization method in grouped feature data for recognizing human cognitive states, comprising: (1) divide feature data into groups; (2) selecting normalization functions and estimating grouping parameters; (3) building grouped normalization functions, substitute normalization function parameters of each group into its normalization function, the normalization mapping relationship of each group is get; (4) grouped normalization processing, each group uses corresponding normalization function to transfer the feature data to finish feature normalization.

Abstract: The present disclosure relates to methods for measuring affective bandwidth of a subject (e.g., a human) and determining depression determination of the subject. The affective bandwidth measurement may include the following operations. For example, the subject may watch positive neutral and negative pictures for 8-10 seconds, respectively. Information for all fixation points may be obtained using an eye movement tracking device. Pupil diameter sizes of the subject while watching the positive, neutral and negative picture tasks may be calculated, and the affective bandwidth may be calculated. The affective bandwidth may include positive affective bandwidth (positive-neutral), negative affective bandwidth (negative-neutral) and positive-negative affective bandwidth (positive-negative) of the subject.

Abstract: The present disclosure relates to methods for measuring affective bandwidth of a subject (e.g., a human) and determining depression determination of the subject. The affective bandwidth measurement may include the following operations. For example, the subject may watch positive neutral and negative pictures for 8-10 seconds, respectively. Information for all fixation points may be obtained using an eye movement tracking device. Pupil diameter sizes of the subject while watching the positive, neutral and negative picture tasks may be calculated, and the affective bandwidth may be calculated. The affective bandwidth may include positive affective bandwidth (positive-neutral), negative affective bandwidth (negative-neutral) and positive-negative affective bandwidth (positive-negative) of the subject.

Abstract: A cable (1) in particular for use in a concentrated solar power installation is provided, is provided with a core (2) for transmitting signals and/or power, an inner jacket (3) enclosing the core, an outer jacket (4) enclosing the inner jacket, and a shield (5) disposed between the inner and outer jackets. The shield is configured as a flexible conduit. A concentrated solar power installation comprising the cable is also provided.