Abstract: Disclosed herein is a gold nanoparticle (AuNP)-based peptide chip prepared by forming a monolayer of AuNPs onto a self-assembled monolayer constructed on a solid support, and then immobilizing a peptide on the AuNPs. The AuNPs can effectively amplify the mass signal of the peptide, thus making it possible to measure the mass change of the peptide in a simple and accurate manner. Also, when secondary ion mass spectrometric analysis (spectrum or imaging) is performed on the AuNP-based peptide chip, the activities of enzymes and related inhibitors can be effectively quantified. The disclosed invention enables various enzyme activities to be analyzed rapidly and accurately, and thus can provide an important method for disease diagnosis and new drug development through the elucidation of signaling and interaction mechanisms.

Abstract: Disclosed herein is a gold nanoparticle (AuNP)-based peptide chip prepared by forming a monolayer of AuNPs onto a self-assembled monolayer constructed on a solid support, and then immobilizing a peptide on the AuNPs. The AuNPs can effectively amplify the mass signal of the peptide, thus making it possible to measure the mass change of the peptide in a simple and accurate manner. Also, when secondary ion mass spectrometric analysis (spectrum or imaging) is performed on the AuNP-based peptide chip, the activities of enzymes and related inhibitors can be effectively quantified. The disclosed invention enables various enzyme activities to be analyzed rapidly and accurately, and thus can provide an important method for disease diagnosis and new drug development through the elucidation of signaling and interaction mechanisms.

Abstract: The present invention relates to (1) a method for detecting a specific binding for bio-molecules; (2) a method for detecting a presence of target molecules within a specimen; and (3) a method for measuring a quantity of target molecules existing in a specimen, in which a pair of energy donor and energy acceptor displaying a FRET phenomenon is used to guide a specific binding between a pair of bio-molecules. According to the present invention, the process is conducted rapidly and easily without a label so as to screen a biochemical substance inhibiting a specific binding between a pair of bio-molecules in an ultra-high speed and measure a quantity of the substance and thereby, it can be applied to develop a novel drug. Further, this method can be used to analyze a characteristic such as change of the amount of carbohydrates in a glycoprotein derived from various cells as a drug candidate and thereby, is applicable for a quality control of proteins etc.

Abstract: The present invention relates to a process for preparing monolayers and microarrays of biomolecules by reacting functionalized dendrimers on a solid surface with biomolecules such as proteins, antigens, antibodies, enzymes, ligands, receptors, and the like. The present invention can be widely applied to the areas including preparation of kits and biosensors for disease diagnosis and compound analyses using the ascribed biomolecules as target substances, and more recently, integrated high-throughput analyzing system such as development of protein chips.

Abstract: The present invention relates to a process for preparing monolayers and microarrays of biomolecules by reacting functionalized dendrimers on a solid surface with biomolecules such as proteins, antigens, antibodies, enzymes, ligands, receptors, and the like. The present invention can be widely applied to the areas including preparation of kits and biosensors for disease diagnosis and compound analyses using the ascribed biomolecules as target substances, and more recently, integrated high-throughput analyzing system such as development of protein chips.

Abstract: A device for fixing the optical elements of an optical fiber amplifier in a packaging box comprises a central opening provided in the packaging box for making a connection with an electronic circuit, an optical fiber holder for holding the erbium doped optical fiber around the central opening, a plurality of guide supports provided in the upper and lower sides of the optical fiber holder for holding the optical isolators, wavelength division multiplexers and optical taps, and protectors provided in the left and right sides of the optical fiber holder for holding the thermocontractile tubes.

Abstract: An erbium doped fiber amplifier having one pumping source which outputs pump power so as to excite a light signal, the amplifier including: a first erbium doped fiber for receiving an excitation light signal input from the pumping source, and amplifying a transmitted light signal input from an input stage; a first wavelength division multiplexer located at an output of the first erbium doped fiber, for inputting the excitation light signal input from the pumping source to the first erbium doped fiber, the first multiplexer also receiving the transmitted light signal amplified from the first erbium doped fiber and outputting it to a next stage; a dispersion compensation fiber at an output of the first wavelength division multiplexer for compensating for loss caused due to the dispersion characteristics of the transmitted light signal; a second wavelength division multiplexer located at an output of the dispersion compensation fiber, for receiving the input transmitted light signal and the excitation light sign

Abstract: An optical fiber amplifier includes an optical filter, an optical isolator for blocking a reverse flow of a reflected light, the optical isolator including a lens coated with an integral filter having a predetermined bandwidth and an output end tab for monitoring the intensity of the output signal, the optical filter being coupled between the optical isolator and output end tab so as to only pass a specified wavelength band.