Abstract: According to the present invention, when nicotinamide is added in a culture process for producing pluripotent stem cells from human differentiated cells, it can increase the efficiency of reprogramming and can significantly reduce the time required for induction of reprogramming. It was verified that nicotinamide inhibits the induction of senescence and oxidative stress in the reprogramming process and increases cell proliferation and mitochondrial activity to effectively improve culture conditions for induction of reprogramming. Particularly, the present invention will contribute to optimizing a process of producing induced pluripotent stem cells from a small amount of patient-specific somatic cells obtained from various sources, and thus it will significantly improve a process of developing clinically applicable personalized stem cell therapy agents and new drugs and will facilitate the practical application of these agents and drugs.

Abstract: A cylindrical lithium secondary battery includes an anode and a cathode, capable of occluding or emitting lithium ions; a non-aqueous electrolyte; and a CID (Current Interrupt Device) for intercepting electric current and lowering inner pressure when the inner pressure of the secondary battery is increased. The cylindrical lithium secondary battery may ensure the safety of the battery with respect to overcharging and also at the same time prevent the problem wherein the CID is activated too early, such that the battery stops its operation when the battery is used in a high-temperature environment.

Abstract: A gate drive circuit for a display device is disclosed, by which output states of scan pulses are identically maintained in a manner of minimizing load deviation between connecting units. The present disclosure includes at least two clock transmission lines transmitting at least two clock pulses having a phase difference in-between, a shift register outputting scan pulses sequentially based on the clock pulses transmitted from the clock transmission lines, and a plurality of connecting units connecting the clock transmission lines to the shift register, respectively, wherein at least one of the connecting units is zigzagged in part, the at least one connecting unit comprising: a pad connected to the corresponding clock transmission line via a pad connecting unit; a zigzagged line connected to one side of the pad; and a connecting line that has one side connected to the zigzagged line and the other side connected to the shift register.

Abstract: Disclosed are an electrolyte for a secondary battery, and a secondary battery including the same, the electrolyte including an electrolyte salt; an electrolyte solvent; and a compound generating heat through oxidation at voltages higher than drive voltage of a cathode, wherein the compound can decompose or evaporate electrolyte components by oxidation heat, thereby causing gas generation. Also, the compound is included in an internal pressure increase accelerant for a battery. Upon overcharge, since a compound subjected to oxidation at voltages higher than normal drive voltage of a cathode generates heat, electrolyte components can be decomposed or evaporated, thereby generating gas by the oxidation heat. Accordingly, it is possible to operate a safety means of a battery, without using an internal pressure increasing material directly generating gas through oxidation at overcharge voltage as the electrolyte additive, and thus to improve the overcharge safety of a secondary battery.

Abstract: A display device including a panel having a display area and first, second, third and fourth non-display areas formed at an outer portion of the display area, said first non-display area facing the second non-display area, and the third non-display area facing the fourth non-display area; a data driver disposed in the first non-display area, and configured to drive a plurality of data lines provided in a first direction in the display area; a gate driver disposed in the second non-display area and configured to drive a plurality of gate lines provided in a second direction vertical to the first direction in the display area; a timing controller configured to drive the data driver and the gate driver; and a plurality of link lines in the display area and extending from the gate driver and provided in parallel to the data lines respectively connected to the gate lines.

Abstract: A reprogramming inducing composition including the Rex1 protein or a nucleic acid molecule coding for the Rex1 protein for producing induced pluripotent stem cells from body cells or non-embryonic cells through a reprogramming process. A method for producing induced pluripotent stem cells by using the Rex1 is also disclosed.

Abstract: The present invention relates to a medium composition comprising neuropeptide Y, effective for proliferation and maintenance of undifferentiated pluripotent stem cells, and a method for culturing undifferentiated pluripotent stem cells using the same. The present invention improves the culture conditions for undifferentiated pluripotent stem cells, and ultimately, the present invention can be effectively used for the development of large-scale culture systems, thereby acquiring clinically applicable pluripotent stem cells. Further, the present invention relates to a dedifferentiation medium composition comprising neuropeptide Y (NPY), and a method for inducing dedifferentiation (or reprogramming) using the same. The present invention improves the culture conditions for dedifferentiation and contributes to develop technology of producing clinically applicable induced pluripotent stem cells, thereby being used for the development of stem cell therapy.

Abstract: A non-aqueous electrolyte solution for a lithium secondary battery includes a lithium salt and an organic solvent and further includes a solvent having a fluoro group and a specific siloxane compound. A lithium secondary battery having the above non-aqueous electrolyte solution exhibits greatly improved capacity recovery characteristics after high temperature storage and also reduces side effects such as swelling.

Abstract: Provided is a detection kit, which a disease detection kit used together with a secondary ion mass spectrometer in order to detect a disease marker contained in a biological sample, the detection kit including: a base including a noble metal thin film formed thereon; a reactant containing peptide specifically reacting with the disease marker; a first storage unit filled with the reactant; a test substance containing a biological sample of a possible disease carrier; a second storage unit filled with the test substance; a mixing unit mixing the reactant and the test substance with each other to prepare a detection substance containing the specific reactant, which is the peptide specifically reacted with the disease marker contained in the biological sample; and a contact unit contacting the detection substance prepared by the mixing unit with the base to bond the specific reactant to the noble metal film of the base.

Abstract: A system includes a learning data input unit for receiving initial and long term characteristic learning data of a battery to be a learning object; a measurement data input unit for receiving initial characteristic measurement data of a battery to be an object for long term characteristic estimation; an artificial neural network operation unit for converting the learning data into first and second data structures, allowing an artificial neural network to learn the learning data based on each data structure, converting the measurement data into first and second data structures, and individually applying the learned artificial neural network corresponding to each data structure to calculate and output long term characteristic estimation data based on each data structure; and a long term characteristic evaluation unit for calculating an error of the estimation data of each data structure and determining reliability of the estimation data depending on error.

Abstract: Disclosed are copper foil or net comprising a Cu-nitrile compound complex formed on the surface thereof, a method for preparing the same, and a lithium secondary battery that comprises an electrode using the same copper foil or net as a collector. The lithium secondary battery, which uses a copper collector comprising a Cu-nitrile compound complex formed on the surface thereof through the application of a certain voltage level, can prevent the corrosion of Cu occurring at a voltage of 3.6V or higher under overdischarge conditions away from the normal drive condition, and thus can significantly improve the capacity restorability after overdischarge.

Abstract: Disclosed are copper foil or net comprising a Cu-nitrile compound complex formed on the surface thereof, a method for preparing the same, and a lithium secondary battery that comprises an electrode using the same copper foil or net as a collector. The lithium secondary battery, which uses a copper collector comprising a Cu-nitrile compound complex formed on the surface thereof through the application of a certain voltage level, can prevent the corrosion of Cu occurring at a voltage of 3.6V or higher under overdischarge conditions away from the normal drive condition, and thus can significantly improve the capacity restorability after overdischarge.

Abstract: The present invention relates to a medium composition comprising neuropeptide Y, effective for proliferation and maintenance of undifferentiated pluripotent stem cells, and a method for culturing undifferentiated pluripotent stem cells using the same. The present invention improves the culture conditions for undifferentiated pluripotent stem cells, and ultimately, the present invention can be effectively used for the development of large-scale culture systems, thereby acquiring clinically applicable pluripotent stem cells. Further, the present invention relates to a dedifferentiation medium composition comprising neuropeptide Y (NPY), and a method for inducing dedifferentiation (or reprogramming) using the same. The present invention improves the culture conditions for dedifferentiation and contributes to develop technology of producing clinically applicable induced pluripotent stem cells, thereby being used for the development of stem cell therapy.

Abstract: Disclosed are copper foil or net comprising a Cu-nitrile compound complex formed on the surface thereof, a method for preparing the same, and a lithium secondary battery that comprises an electrode using the same copper foil or net as a collector. The lithium secondary battery, which uses a copper collector comprising a Cu-nitrile compound complex formed on the surface thereof through the application of a certain voltage level, can prevent the corrosion of Cu occurring at a voltage of 3.6V or higher under overdischarge conditions away from the normal drive condition, and thus can significantly improve the capacity restorability after overdischarge.

Abstract: The present invention relates to a nonaqueous electrolyte solution containing new additives and a lithium secondary battery including the same. More particularly, the invention relates to a nonaqueous electrolyte solution containing a lithium salt, an electrolyte compound, a first additive compound with an oxidation initiation potential of more than 4.2 V, and a second additive compound with an oxidation initiation potential of more than 4.2 V, which is higher in oxidation initiation potential than the first additive, and deposits oxidative products or form a polymer film, in oxidation, as well as a lithium secondary battery including the same. The present invention can provide a lithium secondary battery excellent in both the battery performance and the battery safety in overcharge by the combined use of the first additive and the second battery as additives to the nonaqueous electrolyte solution.

Abstract: A non-aqueous electrolyte solution for a lithium secondary battery includes a lithium salt and an organic solvent and further includes a solvent having a fluoro group and a specific siloxane compound. A lithium secondary battery having the above non-aqueous electrolyte solution exhibits greatly improved capacity recovery characteristics after high temperature storage and also reduces side effects such as swelling.

Abstract: A system for estimating long term characteristics of a battery includes a learning data input unit for receiving initial characteristic learning data and long term characteristic learning data of a battery to be a learning object; a measurement data input unit for receiving initial characteristic measurement data of a battery to be an object for estimation of long term characteristics; and an artificial neural network operation unit for receiving the initial characteristic learning data and the long term characteristic learning data from the learning data input unit to allow learning of an artificial neural network, receiving the initial characteristic measurement data from the measurement data input unit and applying the learned artificial neural network thereto, and thus calculating long term characteristic estimation data from the initial characteristic measurement data of the battery and outputting the long term characteristic estimation data.

Abstract: A cylindrical lithium secondary battery includes an anode and a cathode, capable of occluding or emitting lithium ions; a non-aqueous electrolyte; and a CID (Current Interrupt Device) for intercepting electric current and lowering inner pressure when the inner pressure of the secondary battery is increased. The cylindrical lithium secondary battery may ensure the safety of the battery with respect to overcharging and also at the same time prevent the problem wherein the CID is activated too early, such that the battery stops its operation when the battery is used in a high-temperature environment.

Abstract: A gate drive circuit for a display device is disclosed, by which output states of scan pulses are identically maintained in a manner of minimizing load deviation between connecting units. The present disclosure includes at least two clock transmission lines transmitting at least two clock pulses having a phase difference in-between, a shift register outputting scan pulses sequentially based on the clock pulses transmitted from the clock transmission lines, and a plurality of connecting units connecting the clock transmission lines to the shift register, respectively, wherein at least one of the connecting units is zigzagged in part.

Abstract: A system includes a learning data input unit for receiving initial and long term characteristic learning data of a battery to be a learning object; a measurement data input unit for receiving initial characteristic measurement data of a battery to be an object for long term characteristic estimation; an artificial neural network operation unit for converting the learning data into first and second data structures, allowing an artificial neural network to learn the learning data based on each data structure, converting the measurement data into first and second data structures, and individually applying the learned artificial neural network corresponding to each data structure to calculate and output long term characteristic estimation data based on each data structure; and a long term characteristic evaluation unit for calculating an error of the estimation data of each data structure and determining reliability of the estimation data depending on error.