Patents by Inventor Miae WON

Miae WON has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anticancer prodrug for overcoming drug resistance
    Patent number: 11241501
    Abstract: Disclosed is an anticancer prodrug that disturbs energy metabolism in cancer cells to overcome drug resistance. The anticancer prodrug has a structure including a pyruvate dehydrogenase kinase (PDK) inhibitor moiety, a mitochondrial targeting group, and an anthracycline moiety reversibly connected to the PDK inhibitor moiety and the targeting group.
    Type: Grant
    Filed: August 22, 2019
    Date of Patent: February 8, 2022
    Assignee: Korea University Research and Business Foundation
    Inventors: Jong Seung Kim, Amit Sharma, Min Goo Lee, Miae Won, Jin Yong Lee, Sung-Gil Chi, Jonathan L. Sessler
  • REPURPOSED ANTIBIOTICS FOR NON-NUCLEAR GENOTOXIC CHEMOTHERAPY AND PHARMACEUTICAL COMPOSITION FOR ANTI-CANCER CONTAINING THE SAME
    Publication number: 20220000887
    Abstract: The present invention relates to a repurposed antibiotic compound for the treatment of cancer with minimal nuclear gene damage and an anticancer pharmaceutical composition comprising same. Since the repurposed antibiotic compound has a therapeutic effect in a manner that targets only the mitochondria of cancer cells, the modified antibiotic compound does not cause gene degeneration unlike conventional chemotherapy which damages nuclear DNAs to kill cancer cells, thereby preventing the recurrence of cancer. In addition, a mitochondria targeted therapy using the compound according to the present invention can effectively treat malignant tumors that are difficult to treat due to acquiring drug resistance by general anticancer treatment.
    Type: Application
    Filed: September 17, 2021
    Publication date: January 6, 2022
    Applicant: Korea University Research and Business Foundation
    Inventors: Jong Seung KIM, Kyoung Sunwoo, Peter Verwilst, Miae Won
  • ANTICANCER PRODRUG FOR OVERCOMING DRUG RESISTANCE
    Publication number: 20200129626
    Abstract: Disclosed is an anticancer prodrug that disturbs energy metabolism in cancer cells to overcome drug resistance. The anticancer prodrug has a structure including a pyruvate dehydrogenase kinase (PDK) inhibitor moiety, a mitochondrial targeting group, and an anthracycline moiety reversibly connected to the PDK inhibitor moiety and the targeting group.
    Type: Application
    Filed: August 22, 2019
    Publication date: April 30, 2020
    Applicant: Korea University Research and Business Foundation
    Inventors: Jong Seung KIM, Amit SHARMA, Min Goo LEE, Miae WON, Jin Yong LEE, Sung-Gil CHI, Jonathan L. Sessler