Abstract: Disclosed are amide compounds, preparation method and uses thereof, specifically, the compounds represented by formula I or pharmaceutically acceptable salts, wherein R1, R2, R3, R4, R5, Q, X and n are defined as in the description. Also disclosed are a method for preparing the compounds of formula I, a composition containing the compounds, and the uses of the same in the preparation of medicaments for regulating blood lipid and/or preventing gallstone. The compounds of formula I disclosed in the present invention have stability in vitro, good solubility in the pharmaceutical organic solvents and favorable bioavailability in animals.

Abstract: Disclosed are amide compounds, preparation method and uses thereof, specifically, the compounds represented by formula I or pharmaceutically acceptable salts, wherein R1, R2, R3, R4, R5, Q, X and n are defined as in the description. Also disclosed are a method for preparing the compounds of formula I, a composition containing the compounds, and the uses of the same in the preparation of medicaments for regulating blood lipid and/or preventing gallstone. The compounds of formula I disclosed in the present invention have stability in vitro, good solubility in the pharmaceutical organic solvents and favorable bioavailability in animals.

Abstract: The present invention provides an injectable gel-type bone-repairing bioactive material and its preparation method. Each unit dose of said material is composed of 1 ml of component A and 45 to 55 mg of component B, wherein each milliliter sterile saline of component A contains: 10 to 40 mg alginate, 0.1 to 1 mg bone morphogenetic protein, and 10 to 20 mg stabilizer. In the component B, each milligram (mg) of component B contains: 0.0498 to 0.1476 mg aqueous-indissolvable calcium compound, 0.0498 to 0.2953 gluconolactone, 0.0040 to 0.0159 mg polyvinylpyrrolidone and some bulking agents. Said material has good biocompatibility, which can be applied simply and safely. It can be implanted into a specific treatment site of orthopedic patients without operation. Animal experiments show that the osteogenesis activity of said material is comparable to those solid bone-repairing materials containing identical doses of bone morphogenetic protein, which need to be implanted by surgery.