Abstract: A rocker panel for use in a vehicle, the rocker panel includes an outboard plate, an inboard plate, and a reinforcement structure. The reinforcement structure is disposed between the inboard plate and the outboard plate. The reinforcement structure includes one or more discrete steel tubes extending longitudinally between the outboard plate and the inboard plate.

Abstract: Disclosed is a BCL-2 protein apoptosis inducer, and further disclosed are the uses of the compound and a pharmaceutical composition comprising the compound in the preparation of a drug for treating diseases related to anti-apoptotic protein BCL-2. The compound has potent BCL-2/BAK blocking activity, and can be used for treating diseases such as infectious diseases, immune diseases, inflammatory diseases or cell proliferation abnormalities that benefit from the inhibition of anti-apoptotic protein BCL-2.

Abstract: The present disclosure provides for a semiconductor device with integrated sensing and processing functionalities. The semiconductor device includes a sensing module configured to generate a plurality of analog sensing signals; and a machine learning (ML) processor. The sensing module and the ML processor are fabricated on a single wafer. The ML processor includes crossbar arrays that processes the analog sensing signals to generate analog preprocessed sensing data; an analog-to-digital converter (ADC) to convert the analog preprocessed sensing data into digital preprocessed sensing data; and a machine learning processing unit to process the digital preprocessed sensing data utilizing one or more machine learning model.

Abstract: Disclosed are a Bruton's tyrosine kinase and a mutant degrader thereof; or a stereoisomer thereof, or a stereoisomer mixture thereof or a pharmaceutically acceptable salt thereof, and an application thereof in the preparation of a drug for treating diseases, disorders or conditions that would benefit from the degradation of the Bruton's tyrosine kinase and the mutant thereof. The compound of the present invention can degrade BTK protein, can degrade BTKC481S protein, has an anti-proliferation inhibiting effect on tumor cell strains Mino and OCI-LY10, shows good anti-tumor activity in an OCI-LY10 subcutaneous transplantation tumor model, has an inhibiting effect on B cell activation, and can be applied to B cell or plasma cell proliferative diseases and autoimmune diseases. The compound of the present invention has good oral absorption properties, and can be applied to oral treatment of human or animal B cell or plasma cell proliferative diseases and autoimmune diseases.

Abstract: The present disclosure relates to voltage-mode crossbar circuits that may include a plurality of bit lines intersecting with a plurality of word lines, a plurality of cross-point devices, and a plurality of sensing circuits configured to amplify bit line voltages settled on the bit lines in response to an application of input voltages to the cross-point devices via the word lines and generate digital outputs representative of the amplified bit line voltages. Each cross-point device is connected to one of the word lines and one of the bit lines and may include a resistive random-access memory (RRAM) device. Each cross-point device may further be connected to a local select line that may enable a group of cross-point devices connected to one or more bit lines. A cross-point device may be enabled when both a global select line and the local select line connected to the cross-point device are enabled.

Abstract: In accordance with some embodiments of the present disclosure, an apparatus for performing convolution operations is provided. The apparatus includes a first crossbar circuit comprising a first plurality of cross-point devices; a second crossbar circuit comprising a second plurality of cross-point devices; and a word line logic to apply input signals to the first crossbar circuit and the second crossbar circuit. The word line logic is configured to provide input signals representative of input data to be convolved using one or more two-dimensional convolution kernels and one or more depth-wise convolution kernels. The first crossbar circuit is configured to output a first plurality of output signals representative of a convolution of the input data and the two-dimensional convolution kernels. The second crossbar circuit is configured to output a second plurality of output signals representative of a convolution of the input data and the depth-wise convolution kernels.

Abstract: Disclosed in the present invention is a compound having a structure shown in general formula I, or a stereoisomer thereof, a pharmaceutically acceptable salt thereof, or a solvate thereof. Further disclosed in the present invention are a composition comprising the compound, a preparation and an application. The compound of the present invention has a significant activation effect on KCNQ2/3 potassium ions, and can be used for treating diseases related to potassium channel ion flow, especially for treating central nervous system diseases.

Abstract: An IGBT has a front-surface device region, an IGBT drift region, an IGBT buffer region, and an IGBT collector region that are sequentially connected. The front-surface device region may include a cell region, a field plate region, and a field limiting ring region. The IGBT drift region has a first-type doping element, the IGBT buffer region has a first-type doping element, and a concentration of the first-type doping element in the IGBT buffer region is greater than a concentration of the first-type doping element in the IGBT drift region. The IGBT collector region includes a cell collector region, a field plate collector region, and a field limiting ring collector region. The IGBT collector region has a second-type doping element, and a concentration of a second-type doping element in the cell collector region is greater than a concentration of a second-type doping element in the field plate collector region.

Abstract: In accordance with some embodiments of the present disclosure, an apparatus for performing convolution operations is provided. The apparatus includes a first crossbar circuit comprising a first plurality of cross-point devices; a second crossbar circuit comprising a second plurality of cross-point devices; and a word line logic to apply input signals to the first crossbar circuit and the second crossbar circuit. The word line logic is configured to provide input signals representative of input data to be convolved using one or more two-dimensional convolution kernels and one or more depth-wise convolution kernels. The first crossbar circuit is configured to output a first plurality of output signals representative of a convolution of the input data and the two-dimensional convolution kernels. The second crossbar circuit is configured to output a second plurality of output signals representative of a convolution of the input data and the depth-wise convolution kernels.

Abstract: Adhesives comprising a silyl-terminated polyether and a tackifying resin provide a considerably reduced tack at relatively slight increases in temperature, undergo purely adhesive failure at such increased temperatures, and have reversible properties (i.e., such properties are substantially retained upon cooling). Such adhesives may be used to reversibly bond a first substrate surface coated with the adhesive to a second substrate surface by adhering the substrate surfaces together at a first temperature; heating the adhesive to a second temperature at least about 20° C. above the first temperature and below the thermal degradation temperature; and separating the substrate surfaces from one another at the second temperature, wherein the adhesive comprises the cured product of a silyl-terminated polyether and a tackifier. Such adhesives may also be cleanly transferred from to a different substrate at such elevated temperatures.

Abstract: The present disclosure discloses a crystal form of a casein kinase 1? inhibitor and a preparation method and use of the crystal form. Specifically, the present disclosure relates to a crystal form of the compound (S)-2-(1-(4-amino-3-(2,3-difluoro-4-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-5-chloro-3-phenylquinazoline-4(3H)one methanesulfonate and a preparation method and use of the crystal form. The crystal form of the casein kinase 1? inhibitor compound of the present disclosure has good water solubility and oral absorption, and can be better used for the treatment of malignant tumors and autoimmune diseases that benefit from the inhibition of casein kinase 1? activity.

Abstract: A method for making a plasticized polymer comprises polymerizing a polymerizable monomer, such as an ethylenically unsaturated monomer, in a plasticizer, such as mineral oil, and in the presence of a catalyst system. The plasticized polymer may be mixed with a tackifying resin in a method for making an adhesive. A composition, which may be useful as an adhesive, comprises a polymer system comprising a first polymer; a plasticized system comprising a first plasticizer that was in the presence of the first polymer during the polymerization step to make the first polymer; and a tackifier. The method can be used to make compositions having polymers with a low density or a low molecular weight or both. The final compositions made by methods of the invention include adhesives, sealants, coating, or lubricants.

Abstract: Aspects of the present disclosure provide a method for calibrating crossbar-based apparatuses. The method includes obtaining output data of a crossbar-based apparatus may include a plurality of cross-point devices with tunable conductance, where the output data of the crossbar-based apparatus represents computing results of at least one operation performed by the crossbar-based apparatus, and where the output data corresponding to a plurality of settings of a plurality of analog components of the crossbar-based apparatus. The method also includes obtaining, by a processing device, one or more calibration parameters based on the output data of the crossbar-based apparatus, where the one or more calibration parameters correspond to one or more errors associated with one or more of the analog components of the crossbar-based apparatus. The method further includes calibrating the crossbar-based apparatus using the one or more calibration parameters.

Abstract: In accordance with some embodiments of the present disclosure, an apparatus for performing convolution operations is provided. The apparatus includes a first crossbar circuit comprising a first plurality of cross-point devices; a second crossbar circuit comprising a second plurality of cross-point devices; and a word line logic to apply input signals to the first crossbar circuit and the second crossbar circuit. The word line logic is configured to provide input signals representative of input data to be convolved using one or more two-dimensional convolution kernels and one or more depth-wise convolution kernels. The first crossbar circuit is configured to output a first plurality of output signals representative of a convolution of the input data and the two-dimensional convolution kernels. The second crossbar circuit is configured to output a second plurality of output signals representative of a convolution of the input data and the depth-wise convolution kernels.

Abstract: In one example, a device to process analog sensor data is described. For example, a device may include at least one analog sensor to generate a first set of analog voltage signals and a crossbar array including a plurality of memristors. In one example, the crossbar array is to receive an input vector of the first set of analog voltage signals, generate an output vector comprising a second set of analog voltage signals that is based upon a dot product of the input vector and a matrix comprising resistance values of the plurality of memristors, detect a pattern of the output vector, and activate a processor upon a detection of the pattern.

Abstract: A hot melt adhesive uses a blend of polymers having controlled stereoerror and comprises a stereoblock polypropylene comprising a first block having an isotactic index of between about 50% and about 95% and a second block having an isotactic index of between about 5% and 50%, wherein the difference between the isotactic indeces of the first block and the second block is at least about 10%. The hot melt adhesive exhibits improved peel and tack properties without compromising shear strength and vice versa.

Abstract: Aspects of the present disclosure provide a method for calibrating crossbar-based apparatuses. The method includes obtaining output data of a crossbar-based apparatus may include a plurality of cross-point devices with tunable conductance, where the output data of the crossbar-based apparatus represents computing results of at least one operation performed by the crossbar-based apparatus, and where the output data corresponding to a plurality of settings of a plurality of analog components of the crossbar-based apparatus. The method also includes obtaining, by a processing device, one or more calibration parameters based on the output data of the crossbar-based apparatus, where the one or more calibration parameters correspond to one or more errors associated with one or more of the analog components of the crossbar-based apparatus. The method further includes calibrating the crossbar-based apparatus using the one or more calibration parameters.

Abstract: Aspects of the present disclosure provides a crossbar array circuit including: a crossbar array; a digital-to-analog converter (DAC) configured to receive an input signal to be applied to the crossbar array; a large input resistance connected to the DAC and the crossbar array; and an analog-to-digital converter (ADC) configured to generate output signals of the crossbar array circuit. The crossbar array includes a plurality of cross-point devices connecting a plurality of word lines and a plurality of bit lines. In some embodiments, the crossbar array circuit includes a large output resistance connected to the crossbar array.

Abstract: Disclosed is a novel substituted pyrazolopyrimidine compound that inhibits the activity of casein kinase 1? (CK1?) and a stereoisomer or stereoisomer mixture thereof, or a pharmaceutically acceptable salt or solvate thereof, and an application thereof in preparation of drugs for treating diseases, disorders or conditions that benefit from the inhibition of the activity of the casein kinase 1? (CK1?). The compound of the present invention has an inhibitory activity on CK1? kinase, OCI-LY10 cells and Karpas299 cells, shows good anti-tumor activity in an OCI-LY10 subcutaneous xenogeneic model and shows excellent synergistic anti-tumor activity in combination with BTK inhibitors. The compound of the present invention has good pharmacokinetics properties and may be used alone or in combination with other drugs to treat diseases, disorders or conditions that benefit from the inhibition of the activity of the casein kinase 1?, the diseases, disorders or conditions comprising tumors, autoimmune diseases, etc.

Abstract: Methods of using large output resistance with adjusted conductance mapping value to reduce the current in crossbar array circuit are disclosed. An example method of simulating a crossbar array circuit having a crossbar array, includes steps of: S1. testing the crossbar array; S2. calibrating a simulation model; S3. simulating the crossbar array with the simulation model, wherein a simulation result is generated after the S3; S4. determining a fixed ratio of ideal current from the simulation result; S5. adjusting conductance mapping value to let the crossbar array pass the fixed ratio of ideal current and generating a conductance matrix; S6. programming the conductance matrix to the crossbar array; S7. passing an input signal to the crossbar array and generating a computing result; and S8. checking the quality of computing results.