Abstract: Aspects of this disclosure include technologies for object registration based on a dual-stream pyramid registration network, which is configured to compute multi-scale deformation fields from dual feature pyramids. The disclosed technologies further enable the multi-scale deformation fields to be refined in a coarse-to-fine manner, resulting in the capability for handling significant deformations between two objects, such as large displacements in spatial domain or slice space. Further, the disclosed technologies enable various functions based on the registered objects, such as automatic labeling, image comparison and differentiation, and medical image registration and navigation.